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Total 206 results found since Jan 2013.

Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway
J Zhejiang Univ Sci B. 2021 Feb 15;22(2):123-135. doi: 10.1631/jzus.B2000540.ABSTRACTIschemic stroke presents a leading cause of mortality and morbidity worldwide. Theaflavic acid (TFA) is a theaflavin isolated from black tea that exerts a potentially neuro-protective effect. However, the dynamic properties of TFA-mediated protection remain largely unknown. In the current study, we evaluated the function of TFA in the mitochondria apoptotic pathway using mathematical modeling. We found that TFA-enhanced B-cell lymphoma 2 (Bcl-2) overexpression can theoretically give rise to bistability. The bistability is highly robust aga...
Source: J Zhejiang Univ Sci ... - February 22, 2021 Category: Science Authors: Dan Mu Huaguang Qin Mengjie Jiao Shaogui Hua Tingzhe Sun Source Type: research

Effects of the methanol fraction of modified Seonghyangjeongki-san water extract on transient ischaemic brain injury in mice
CONCLUSIONS: SHJKSmex protected the brain from ischaemic stroke in mice through its antioxidant, anti-inflammatory, and antiapoptotic activities. Our findings suggest that SHJKSmex is a promising therapeutic candidate for the development of a new formulation for ischaemia-induced brain damage.PMID:34184969 | DOI:10.1080/13880209.2021.1941130
Source: Pharmaceutical Biology - June 29, 2021 Category: Drugs & Pharmacology Authors: Eun-Jin Kang Suin Cho Chiyeon Lim Byoungho Lee Young Kyun Kim Kyoung-Min Kim Source Type: research

Circular noncoding RNA circ_0007865, serves as a competing endogenous RNA, targeting the miR-214-3p/FKBP5 axis to regulate oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells
Conclusion According to these results, circ_0007865 deficiency could attenuate OGD-induced HBMEC damage by modulating the miR-214-3p/FKBP5 axis, hinting at a promising therapeutic target for future acute IS therapy.
Source: NeuroReport - February 11, 2022 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Cancers, Vol. 15, Pages 3992: Long-Term Adverse Effects of Neck Radiotherapy in Childhood on the Carotid Arteries in Survivors of Hodgkin Lymphoma
Conclusions: Vascular changes in survivors of childhood Hodgkin lymphoma after neck RT seem to be long-term. Therefore, these patients may have an increased risk of stroke. We suggest refinement of international guidelines according to our results.
Source: Cancers - August 6, 2023 Category: Cancer & Oncology Authors: Matja ž Popit Marjan Zaletel Bojana Žvan Lorna Zadravec Zaletel Tags: Article Source Type: research

Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL
Conclusions: This study showed that USPIO-enhanced brain MRI can be useful in the diagnosis of CNS inflammatory disorders and lymphoma, and is also useful for patients with renal compromise at risk of nephrogenic systemic fibrosis who are unable to receive GBCA.
Source: Neurology - July 15, 2013 Category: Neurology Authors: Farrell, B. T., Hamilton, B. E., Dosa, E., Rimely, E., Nasseri, M., Gahramanov, S., Lacy, C. A., Frenkel, E. P., Doolittle, N. D., Jacobs, P. M., Neuwelt, E. A. Tags: MRI, All Cerebrovascular disease/Stroke, All Oncology ARTICLE Source Type: research

Clinical Features of Radiation-induced Carotid Atherosclerosis.
Abstract Carotid arteries frequently receive significant incidental doses of radiation during the treatment of malignant diseases, including head and neck cancer, breast cancer and lymphoma. Vascular injury after treatment may result in carotid artery stenosis and increased risk of neurological sequelae, such as stroke and transient ischaemic attack. The long latent interval from treatment to the development of clinical complications makes investigation of this process difficult, particularly in regard to the design of interventional clinical studies. Nevertheless, there is compelling clinical evidence that radiat...
Source: Clinical Genitourinary Cancer - November 1, 2013 Category: Cancer & Oncology Authors: Gujral DM, Shah BN, Chahal NS, Senior R, Harrington KJ, Nutting CM Tags: Clin Oncol (R Coll Radiol) Source Type: research

Clinical Features of Radiation-induced Carotid Atherosclerosis
Abstract: Carotid arteries frequently receive significant incidental doses of radiation during the treatment of malignant diseases, including head and neck cancer, breast cancer and lymphoma. Vascular injury after treatment may result in carotid artery stenosis and increased risk of neurological sequelae, such as stroke and transient ischaemic attack. The long latent interval from treatment to the development of clinical complications makes investigation of this process difficult, particularly in regard to the design of interventional clinical studies. Nevertheless, there is compelling clinical evidence that radiation cont...
Source: Clinical Oncology - November 4, 2013 Category: Radiology Authors: D.M. Gujral, B.N. Shah, N.S. Chahal, R. Senior, K.J. Harrington, C.M. Nutting Tags: Overview Source Type: research

Metabolic consequences of Helicobacter pylori infection and eradication.
Abstract Helicobacter pylori (H. pylori) is still the most prevalent infection of the world. Colonization of the stomach by this agent will invariably induce chronic gastritis which is a low-grade inflammatory state leading to local complications (peptic ulcer, gastric cancer, lymphoma) and remote manifestations. While H. pylori does not enter circulation, these extragastric manifestations are probably mediated by the cytokines and acute phase proteins produced by the inflammed mucosa. The epidemiologic link between the H. pylori infection and metabolic changes is inconstant and controversial. Growth delay was des...
Source: World Journal of Gastroenterology : WJG - May 14, 2014 Category: Gastroenterology Authors: Buzás GM Tags: World J Gastroenterol Source Type: research

Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect
The objective of present study is to investigate the role of CKLF1 on neuronal apoptosis by applying anti-CKLF1 antibodies in rat focal cerebral ischemia and reperfusion model. Antibodies against CKLF1 was applied to the right cerebral ventricle immediately after transient middle cerebral artery occlusion (MCAO), and infarct volume, neurological score, glucose metabolism and apoptosis-related protein were measured. Treatment with anti-CKLF1 antibody decreased infarct volume and neurological score, and inhibited neuronal apoptosis in a dose-dependent manner at 24h after reperfusion. Anti-CKLF1 antibody also reduced the leve...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research