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Ischemic Stroke Following Ergotamine Overdose
The use of ergotamine in the treatment of migraine has become disputed because of its significant side effects, such as arterial vasospasm particularly affecting the peripheral arteries.1 However, there is conflicting evidence about the effect of ergotamine on cerebral blood flow.2-4 At present, ergotamine continues to be utilized, albeit off-license, for the treatment of refractory migraine in pediatric patients.5 Yet, there is a lack of evidence supporting ergotamine's utility and safety in migraine treatment.
Source: Pediatric Neurology - August 5, 2019 Category: Neurology Authors: Nadja F. Bednarczuk, Ming Lim, Ata Siddiqui, Karine Lascelles Tags: Clinical Letter Source Type: research

Gender differences in association of prescription opioid use and mortality: a propensity-matched analysis from the REasons for Geographic And Racial Differences in Stroke (REGARDS) prospective cohort - Khodneva Y, Richman J, Kertesz S, Safford MM.
Background: Prescription opioids (PO) have been widely used for chronic non-cancer pain, with commensurate concerns for overdose. The long-term effect of these medications on non-overdose mortality in the general population remains poorly understood...
Source: SafetyLit - December 23, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Possible Interaction between Dabigatran and Ranolazine in Patients with Renal Failure.
Abstract Dabigatran etexilate is a direct oral anticoagulant (thrombin inhibitor) used for the prevention of stroke and systemic thromboembolic events in patients with permanent atrial fibrillation; prevention of venous thromboembolic events and deep veins thrombosis; treatment and prevention of pulmonary embolism. Dabigatran is a relatively new drug, and as a result, its interactions with other medications and their significance are not fully known. A 72 years old male, having a medical history of heart and renal failure, was hospitalized for pneumonia treatment. The patient was taking several drugs, including da...
Source: Medicina (Kaunas) - December 28, 2019 Category: Universities & Medical Training Authors: Gumbrevičius G, Damulevičienė G, Galaunė V, Gumbrevičiūtė M Tags: Medicina (Kaunas) Source Type: research

For the First Time in Four Years, the U.S. Life Expectancy Rose a Little
(NEW YORK) — Life expectancy in the United States is up for the first time in four years. The increase is small — just a month — but marks at least a temporary halt to a downward trend. The rise is due to lower death rates for cancer and drug overdoses. “Let’s just hope it continues,” said Robert Anderson, who oversees the report released Thursday by the Centers for Disease Control and Prevention. The latest calculation is for 2018 and factors in current death trends and other issues. On average, an infant born that year is expected to live about 78 years and 8 months, the CDC said. For...
Source: TIME: Health - January 30, 2020 Category: Consumer Health News Authors: Associated Press Tags: Uncategorized health onetime overnight Source Type: news

Degree of Bystander-Patient Relationship and Prehospital Care for Opioid Overdose.
ConclusionPresence of a proximal bystander during an overdose event is associated with dispatch codes indicative of an overdose and shorter times to naloxone administration compared with those with distal bystanders. These findings offer opportunities for public education and engagement of overdose harm reduction strategies. PMID: 32073921 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - February 21, 2020 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Degree of bystander-patient relationship and prehospital care for opioid overdose - McCann MK, Jusko TA, Jones CMC, Seplaki CL, Cushman JT.
BackgroundAcross the spectrum of patient care for opioid overdose, an important, yet frequently overlooked feature is the bystander, or witness to the overdose event. For other acute medical events such as cardiac arrest and stroke, research supports that ...
Source: SafetyLit - February 24, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Effect of Donor Death by Drug Intoxication Combined with Chronic Drug Abuse on Lung Transplantation: A Single Center Study
In the field of lung transplantation, there is a high wait list mortality. Broader use of extended criteria donors would provide additional organs for transplantation. An increasing number of organ donors are dying from drug overdose. These donors are often considered “high risk” because of their exposure to infectious diseases such as HIV and Hepatitis B and C. However, these organ donors are often younger and healthier than those that die from stroke or cardiac arrest. Successful use of lung donors who have a history of drug abuse may serve to provide addit ional organs for those patients on the wait list.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: E.C. Klipsch, T. Hathaway, R.S. Mangus Tags: (330) Source Type: research

Intravenous Fat Emulsion Does Not Significantly Alter Clotting Markers in Dabigatran-Treated Blood
AbstractDabigatran etexilate is an oral direct thrombin (Factor IIa) inhibitor approved for patients with atrial fibrillation and for management of risk of deep vein thrombosis and pulmonary embolism. Dabigatran offers advantages over treatment with warfarin, including limited laboratory monitoring. It is equivalent in prevention of stroke and deep vein thrombosis with essentially equivalent complication rates. In contrast to warfarin, reversal of the anticoagulation is less well established. Idarucizumab is available for reversal, however supporting research is mixed; the agent also happens to be quite expensive making av...
Source: Indian Journal of Hematology and Blood Transfusion - June 21, 2020 Category: Hematology Source Type: research

The Difficulty Of Counting the COVID-19 Pandemic ’s Full Death Toll
Sara Wittner had seemingly gotten her life back under control. After a December relapse in her battle with drug addiction, the 32-year-old completed a 30-day detox program and started taking a monthly injection to block her cravings for opioids. She was engaged to be married, working for a local health advocacy group in Colorado, and counseling others about drug addiction. Then the COVID-19 pandemic hit. The virus knocked down all the supports she had carefully built around her: no more in-person Narcotics Anonymous meetings, no talks over coffee with trusted friends or her addiction recovery sponsor. As the virus stressed...
Source: TIME: Health - June 22, 2020 Category: Consumer Health News Authors: Markian Hawryluk / Kaiser Health News Tags: Uncategorized COVID-19 Source Type: news

High Fluctuation Between Anticoagulants, Frequent Off-Label Dosing, and No Difference Concerning Outcomes: Results of a Real-Life Cohort Study
Recently published studies indicated a high proportion of patients taking direct oral anticoagulants (DOACs) are off-label under- or overdosed. The present study aimed at investigating whether off-label dosages are corrected over time and whether off-label doses are associated with differences in bleeding rates, ischemic stroke, or venous thromboembolism.
Source: The American Journal of Medicine - October 24, 2020 Category: General Medicine Authors: Corinne M. Eschler, Ana Antelo, Georg-Christian Funk, Aristomenis K. Exadaktylos, Gregor Lindner Tags: Clinical Research Study Source Type: research

Overdose Receiving Centers - An Idea Whose Time Has Come?
Authors: Hern HG, Goldstein D, Tzvieli O, Mercer M, Sporer K, Herring AA Abstract Drug overdose deaths have been the leading cause of accidental death in the United States with two thirds involving opioids. Strong evidence supports the efficacy of medications for addiction treatment such as buprenorphine and harm reduction strategies such as naloxone distribution. While emergency medical service (EMS) systems have defined specialty centers for the treatment of many significant life threatening disease (trauma, stroke, myocardial infarction) implementation of opioid use disorder systems of care that integrate EMS ar...
Source: Prehospital Emergency Care - January 30, 2021 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

‘I Truly Did Find My Calling.’ Meet the Young People Shaping Health Care’s Post-Pandemic Future
The COVID-19 pandemic has been exhausting for the world’s health care workers, who have spent the last year-plus putting their lives on the line to keep the rest of us safe and healthy. Now, their tireless efforts are inspiring a new generation to join their ranks: applications to U.S. medical schools shot up nearly 20% in fall 2021, according to the Association of American Medical Colleges. Individual schools are reporting similar spikes—New York University’s Rory Meyers College of Nursing saw a 33% increase in applications this year over the previous year, for instance. To learn more about the people wh...
Source: TIME: Health - June 10, 2021 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized COVID-19 Source Type: news

IJERPH, Vol. 18, Pages 6889: Measuring the Level of Medical-Emergency-Related Knowledge among Senior Dental Students and Clinical Trainers
Conclusions: The overall knowledge regarding the management of medical emergency crises in the dental chair was moderate. However, the scale of knowledge regarding the management of medical emergency crises has gradually increased with the number of years of experience. Most participants recognize the need for further training.
Source: International Journal of Environmental Research and Public Health - June 27, 2021 Category: Environmental Health Authors: Giath Gazal Hamzah Aljohani Khalid H Al-Samadani Mohammad Zakaria Nassani Tags: Article Source Type: research

N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)
CONCLUSION: The use of N-acetylcysteine should be considered in a number of conditions as our population ages and levels of glutathione drop. Supplementation may contribute to reducing morbidity and mortality in some chronic conditions as outlined in the article.PMID:34221501 | PMC:PMC8211525 | DOI:10.1155/2021/9949453
Source: Journal of Nutrition and Metabolism - July 5, 2021 Category: Nutrition Authors: Gerry K Schwalfenberg Source Type: research