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Condition: Arteriosclerosis

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Total 577 results found since Jan 2013.

Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery: A Scientific Statement From the American Heart Association/American Stroke Association
Circulation. 2021 Apr 8:CIR0000000000000968. doi: 10.1161/CIR.0000000000000968. Online ahead of print.ABSTRACTPerioperative stroke is a potentially devastating complication in patients undergoing noncardiac, nonneurological surgery. This scientific statement summarizes established risk factors for perioperative stroke, preoperative and intraoperative strategies to mitigate the risk of stroke, suggestions for postoperative assessments, and treatment approaches for minimizing permanent neurological dysfunction in patients who experience a perioperative stroke. The first section focuses on preoperative optimization, including...
Source: Circulation - April 8, 2021 Category: Cardiology Authors: Curtis Benesch Laurent G Glance Colin P Derdeyn Lee A Fleisher Robert G Holloway Steven R Mess é Christina Mijalski M Timothy Nelson Martha Power Babu G Welch American Heart Association Stroke Council; Council on Arteriosclerosis, Thrombosis and Vascular Source Type: research

Intracranial Carotid Artery Calcification Relates to Recanalization and Clinical Outcome After Mechanical Thrombectomy Clinical Sciences
Conclusions—A larger amount of ICAC before mechanical thrombectomy in acute stroke patients is an indicator of worse postprocedural arterial revascularization and poorer functional outcome.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Maria Hernandez–Perez, Daniel Bos, Laura Dorado, Karliȷn Pellikaan, Meike W. Vernooiȷ, Elena Lopez–Cancio, Natalia Perez de la Ossa, Meritxell Gomis, Carlos Castano, Josep Munuera, Josep Puig, Monica Millan, Antoni Davalos Tags: Computerized Tomography (CT), Imaging, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

RNA binding protein RPS3 mediates microglial polarization by activating NLRP3 inflammasome via SIRT1 in ischemic stroke
Stroke remains the leading cause of death and permanent disability worldwide and ischemic stroke represents 80% of all cases, which brings extremely serious consequences to the family and society.1 Ischemic stroke refers to the general term of cerebral blood supply artery stenosis or occlusion leading to cerebral blood circulation disorder, insufficient blood supply and brain tissue necrosis.2 Cerebral ischemic stroke occurs in middle-aged and elderly people, and arteriosclerosis and hypertension are the main pathogenic factors.
Source: Journal of Stroke and Cerebrovascular Diseases - April 21, 2023 Category: Neurology Authors: Dimi Zhou, Lin Chen, Yuzheng Wang, Lu Gan, Mei Yuan, Lei Zhang, Fenfang Chen Source Type: research

Challenge of Identifying the Cause of Intracranial Artery Stenosis in Patients With Ischemic Stroke Illustrative Teaching Case
Source: Stroke - February 23, 2015 Category: Neurology Authors: Lanthier, S., Odier, C., Sundararajan, S., Strbian, D. Tags: Secondary prevention, Other arteriosclerosis, Other diagnostic testing, Stroke in Children and the Young, Vasculitis Brain Arteries Illustrative Teaching Case Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Stroke after adult-onset epilepsy: A population-based retrospective cohort study.
CONCLUSION: Adult-onset epilepsy at age 35 and older warrants consideration for occult cerebrovascular disease as an etiology of the epilepsy, which may also increase the risk of subsequent stroke. Somatic comorbidities frequently associated with epilepsy include comorbid conditions that share the same underlying pathology with stroke (i.e., hypertension, hyperlipidemia, myocardial infarction, diabetes, and arteriosclerosis). This increased risk of stroke in patients with adult-onset epilepsy should dictate the evaluation and management of stroke risk factors to prevent stroke. PMID: 25575071 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - January 6, 2015 Category: Neurology Authors: Wannamaker BB, Wilson DA, Malek AM, Selassie AW Tags: Epilepsy Behav Source Type: research

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack.
CONCLUSIONS: PPAR-γ agonists were demonstrated to reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and improve insulin sensitivity and the stabilisation of carotid plaques. There is evidence of limited quality that they are well-tolerated. However, the conclusions should be interpreted with caution considering the small number and the quality of the included studies. In future, well-designed, double-blind RCTs with large samples are required to test the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular ev...
Source: Cochrane Database of Systematic Reviews - January 8, 2014 Category: Journals (General) Authors: Liu J, Wang LN Tags: Cochrane Database Syst Rev Source Type: research

Stroke after adult-onset epilepsy: A population-based retrospective cohort study
Conclusion Adult-onset epilepsy at age 35 and older warrants consideration for occult cerebrovascular disease as an etiology of the epilepsy, which may also increase the risk of subsequent stroke. Somatic comorbidities frequently associated with epilepsy include comorbid conditions that share the same underlying pathology with stroke (i.e., hypertension, hyperlipidemia, myocardial infarction, diabetes, and arteriosclerosis). This increased risk of stroke in patients with adult-onset epilepsy should dictate the evaluation and management of stroke risk factors to prevent stroke.
Source: Epilepsy and Behavior - January 7, 2015 Category: Neurology Source Type: research

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack.
CONCLUSIONS: PPAR-γ agonists appear to reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and improve insulin sensitivity and the stabilisation of carotid plaques. There is evidence of limited quality that they are well tolerated. However, the conclusions should be interpreted with caution considering the small number and the quality of the included studies. In future, well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular events in p...
Source: Cochrane Database of Systematic Reviews - October 29, 2015 Category: Journals (General) Authors: Liu J, Wang LN Tags: Cochrane Database Syst Rev Source Type: research

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack.
CONCLUSIONS: Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular...
Source: Cochrane Database of Systematic Reviews - December 2, 2017 Category: General Medicine Authors: Liu J, Wang LN Tags: Cochrane Database Syst Rev Source Type: research

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
CONCLUSIONS: Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular...
Source: Cochrane Database of Systematic Reviews - January 10, 2023 Category: General Medicine Authors: Jia Liu Lu-Ning Wang Source Type: research

Medium-Chain Acylcarnitines Are Associated With Cardioembolic Stroke and Stroke Recurrence: A Metabolomics Study.
CONCLUSIONS: Metabolomics provided an improved understanding of CE pathogenesis and stroke recurrence. We have identified decanoylcarnitine and octanoylcarnitine as novel biomarkers for CE and stroke recurrence. PMID: 30026276 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 19, 2018 Category: Cardiology Authors: Seo WK, Jo G, Shin MJ, Oh K Tags: Arterioscler Thromb Vasc Biol Source Type: research