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Total 356 results found since Jan 2013.

Cerebellar Stroke and Leptomeningeal Carcinomatosis following Cement Leakage into the Vertebral Artery during Cervical Vertebroplasty
This report describes an unusual vertebral artery cement embolization during C3 transpedicular vertebroplasty performed under computed tomography (CT) guidance and fluoroscopy. The Institutional Review Board approved this case report, and the patient ’s consent for publication was obtained. A 54-year-old woman with an invasive lobular breast carcinoma suffered from cervical pain. A CT scan showed spinal osteolytic lesions. A thoracic vertebral biopsy confirmed the diagnosis of breast cancer metastasis.
Source: Journal of Vascular and Interventional Radiology : JVIR - September 28, 2021 Category: Radiology Authors: Fabrice Bing, Jad Dandache, Luce Mettey, Wilfried Vadot, Laetitia Stefani Tags: Letter to the Editor Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief
Digital media& downloads Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief Researchers targeted a common sodium ion channel to reverse pain and saw positive results that could lead to a nonaddictive solution to treat pain. Today University of Arizona Health Sciencespain-relief-web.jpgHealthBIO5College of Medicine - TucsonExpertsResearch Media contact(s)Stacy Pigott University of Arizona Health Sciencesspigott@arizona.edu520-539-4152Researchers at the University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed that...
Source: The University of Arizona: Health - November 15, 2021 Category: Universities & Medical Training Authors: mittank Source Type: research

Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development
J Biochem. 2021 Dec 30:mvab143. doi: 10.1093/jb/mvab143. Online ahead of print.ABSTRACTIn addition to diurnal rhythms in physiology and behavior, a variety of pathological conditions also exhibit marked day-night changes in symptom intensity, exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and chronic pain disorders. Currently, novel therapeutic approaches are facilitated by the development of chemical compounds targeted to key proteins that cause diurnal exacerbation of pathological events. Neuropathic pain is a chronic condition that occurs by tumor-induced ne...
Source: Herpes - December 30, 2021 Category: Infectious Diseases Authors: Satoru Koyanagi Naoki Kusunose Sai Yasukochi Shigehiro Ohdo Source Type: research

Tube feeding in patients with dementia is associated with a longer palliative care unit stay
CONCLUSION: The present study showed that, in patients with an established diagnosis of dementia, TF is common and independently associated with a longer length of PCU stay. Nevertheless, the study was underpowered and the results deserve confirmation in larger studies.PMID:34971282 | DOI:10.1002/alz.052919
Source: The Journal of Alzheimers Association - December 31, 2021 Category: Psychiatry Authors: Hilal Zengin Ilker Tasci Source Type: research

Why You Shouldn ’t Exercise to Lose Weight
Many of us are lacing up our sneakers and starting (or restarting) exercise regimens in hopes of shedding unwanted pounds. Unquestionably, aiming to be more active is a good thing. But if the main reason is to lose weight, your New Year’s resolution could very well backfire. For starters, exercise—at least the kind most of us do—is typically ineffective for weight loss. Take walking, for example. A 150-pound person who walks briskly for 30 minutes will burn, on average, around 140 calories. That’s equal to one can of soda—not exactly a great return on your investment of time and effort. It&rsq...
Source: TIME: Health - January 12, 2022 Category: Consumer Health News Authors: Robert J. Davis Tags: Uncategorized Source Type: news

New ERLEADA ® (apalutamide) Analysis Demonstrates Rapid, Deep Prostate-Specific Antigen (PSA) Response in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new real-world evidence data showing the initiation of ERLEADA® (apalutamide) results in high rates of rapid and deep prostate-specific antigen (PSA) response among patients with metastatic castration-sensitive prostate cancer (mCSPC). In a separate post-hoc analysis of the registrational Phase 3 SPARTAN and TITAN studies, rapid and deep PSA responses with ERLEADA® were associated with improvement in patient-reported outcomes (PROs) related to quality of life, physical wellbeing, pain, and fatigue intensity. The...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

IJERPH, Vol. 19, Pages 2666: Negative Self-Assessment of Health in Women: Association with Sociodemographic Characteristics, Physical Inactivity and Multimorbidity
Conclusion: The prevalence of NSAH was low. A strong association was found between this variable and multimorbidity. In addition, increased age, low schooling and physical inactivity were predictors of NSAH in women.
Source: International Journal of Environmental Research and Public Health - February 25, 2022 Category: Environmental Health Authors: Thays Ang élica de Pinho Santos Rafael Alves Guimar ães Val éria Pagotto Nat ália Del’ Angelo Aredes Isabela Silva Levindo de Siqueira Suiany Dias Rocha Clarissa Irineu de Sousa Carrijo Claci F átima Weirich Rosso Tags: Article Source Type: research

Understanding health problems in people with extremely low health-related quality of life in Korea
This study targeted population with inferior HRQoL and examined their problems experienced with HRQoL dimensions, and impacts of different morbidities on these problems. Data were obtained from a population-based survey in Korea. HRQoL was measured by EQ-5D questionnaire and low-HRQoL population was defined as individuals whose EQ-5D utility score was among the lowest 5% of total survey population. Logistic regression models were used to evaluate the impact of fifteen morbidities on HRQoL dimensions. Of 2976 low-HRQoL participants, females and low socioeconomic individuals were predominant. They experienced significantly m...
Source: Cancer Control - March 9, 2022 Category: Cancer & Oncology Authors: Thi Xuan Mai Tran Sanghee Lee Chang-Mo Oh Yoon Jung Chang Hyunsoon Cho Source Type: research

Adipocytokines: Emerging therapeutic targets for pain management
Biomed Pharmacother. 2022 Mar 10;149:112813. doi: 10.1016/j.biopha.2022.112813. Online ahead of print.ABSTRACTAlthough pain has lower mortality rates than cancer, diabetes and stroke, pain is a predominate source of distress and disability. However, the management of pain remains an enormous problem. Many drugs used to pain treatment have more or less side effects. Therefore, the development of novel therapeutic target is critical for the treatment of pain. Notably, studies have shown that adipocytokines have a dual role in pain. Growing shreds of evidence shows that the levels of adipocytokines are upregulated or downregu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 13, 2022 Category: Drugs & Pharmacology Authors: Shao-Jie Gao Dai-Qiang Liu Dan-Yang Li Jia Sun Long-Qing Zhang Jia-Yi Wu Fan-He Song Ya-Qun Zhou Wei Mei Source Type: research

Molecules, Vol. 27, Pages 2054: Molecular Simulations and Drug Discovery of Adenosine Receptors
long Miao G protein-coupled receptors (GPCRs) represent the largest family of human membrane proteins. Four subtypes of adenosine receptors (ARs), the A1AR, A2AAR, A2BAR and A3AR, each with a unique pharmacological profile and distribution within the tissues in the human body, mediate many physiological functions and serve as critical drug targets for treating numerous human diseases including cancer, neuropathic pain, cardiac ischemia, stroke and diabetes. The A1AR and A3AR preferentially couple to the Gi/o proteins, while the A2AAR and A2BAR prefer coupling to the Gs proteins. Adenosine receptors were the first subcl...
Source: Molecules - March 22, 2022 Category: Chemistry Authors: Jinan Wang Apurba Bhattarai Hung N. Do Sana Akhter Yinglong Miao Tags: Review Source Type: research

Pharmaceutical perspective of neuropathic pain management for primary care providers
Inflammopharmacology. 2022 Mar 28. doi: 10.1007/s10787-022-00963-7. Online ahead of print.ABSTRACTNeuropathic pain (NP) is a chronic condition that affects ~ 1% of the general population globally. Several conditions such as chronic diabetes, herpes zoster (HZ), cancer, HIV, stroke, multiple sclerosis, physical compression or damage of nerves and certain surgical procedures can lead to neuropathy and related pain. The condition is difficult to treat with traditional analgesic drugs. Typically, non-traditional analgesics are used in treating pain in this condition such as antidepressants and antiepileptic drugs. Opioids are ...
Source: Herpes - March 29, 2022 Category: Infectious Diseases Authors: Sandhya Jinesh Justin Kullgren Gollapudi S Shankar Rajan Radhakrishnan Source Type: research

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