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Specialty: Internal Medicine
Condition: Hypertension
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Total 432 results found since Jan 2013.
Risk of vascular events is lower than expected in patients with transient ischaemic attack or minor stroke treated promptly by stroke specialists
Commentary on: Amarenco P, Lavallée PC, Labreuche J, et al.., TIAregistry.org Investigators. One-year risk of stroke after transient ischemic attack or minor stroke. N Engl J Med 2016;374:1533–42. Context Previous studies estimated the risk of subsequent vascular events in patients with transient ischaemic attack (TIA) or minor stroke at 10–20% within 3 months.1 2 Prevention strategies have been adjusted since. Up-to-date numbers would help to detect a possible temporal trend in risk and to prospectively evaluate risk-scoring tools and specific risk factors in current patient populations. The TIA re...
Source: Evidence-Based Medicine - July 25, 2016 Category: Internal Medicine Authors: Nolte, C. H. Tags: EBM Prognosis, Drugs: cardiovascular system, Stroke, Hypertension, Ischaemic heart disease Source Type: research
Aspirin plus clopidogrel in acute minor ischaemic stroke or transient ischaemic attack is superior to aspirin alone for stroke risk reduction: CHANCE trial
Commentary on: Wang Y, Wang Y, Zhao X, et al.. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11–19. Context Combination therapy with aspirin added to clopidogrel has had a disappointing record in the prevention of recurrent stroke. The management of atherothrombosis with clopidogrel in high-risk patients (MATCH)1 and the secondary prevention of small subcortical strokes (SPS3)2 randomised controlled trials (RCTs) showed that combination therapy was not more effective than clopidogrel or aspirin alone, but was associated with two to three times the risk of major or ...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Gorelick, P. B., Farooq, M. U. Tags: Smoking and tobacco, Clinical trials (epidemiology), Genetics, Stroke, Hypertension, Diabetes, Health education, Smoking Therapeutics Source Type: research
Overenthusiastic stroke risk factor modification in the over-80s: Are we being disingenuous to ourselves, and to our oldest patients?
Statins and antihypertensive therapy are widely used in our oldest patients (ie, those aged over 80 years). The epidemiology suggests that, by this age, hypertension is not an attributable risk factor for stroke, and hypercholesterolaemia has little effect on stroke risk overall. The largest trials of antihypertensive therapy and statins in this age group show at best a marginal clinical reduction in stroke and very modest clinical reductions in other cardiovascular end points. Older patients have very diverse views on the relative importance of stroke and death as end points, and these differ from physicians’ views....
Source: Evidence-Based Medicine - July 18, 2014 Category: Internal Medicine Authors: Byatt, K. Tags: Geriatric medicine, Clinical trials (epidemiology), Editor's choice, Press releases, Drugs: cardiovascular system, Stroke, Hypertension, Ethics, Legal and forensic medicine, Lipid disorders Perspective Source Type: research
Risk of warfarin-associated intracerebral haemorrhage after ischaemic stroke is low and unchanged during the 2000s
Commentary on: Asberg A, Erisksson M, Henriksson KM, et al.. Warfarin-associated intracerebral hemorrhage after ischemic stroke. Stroke 2014;45:2118–20. Context Since its isolation during the early half of the 20th century from the mouldy hay responsible for ‘sweet clover disease’ in cattle, warfarin has become the most widely used oral anticoagulant.1 Indications include atrial fibrillation (AF), mechanical prosthetic valves and venous thromboembolism treatment.2 Warfarin reduces stroke risk in patients with AF by nearly two-thirds; AF accounts for 20% of ischaemic strokes, which tend to be more severe t...
Source: Evidence-Based Medicine - January 21, 2015 Category: Internal Medicine Authors: Ruland, S., Biller, J. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Alcohol-related disorders, Drugs misuse (including addiction), Arrhythmias, Alcohol, Health education Aetiology/Harm Source Type: research
Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study
ConclusionsNight-onset strokes, compared with day-onset strokes, are associated with higher presenting neurologic severity, more frequent END, and worse 3-month functional outcome. These findings suggest that circadian time of onset is an important additional variable for inclusion in epidemiologic natural history studies and in treatment trials of neuroprotective and reperfusion agents for acute ischemic stroke.
Source: PLoS Medicine - February 4, 2022 Category: Internal Medicine Authors: Wi-Sun Ryu Source Type: research
Association between heat stroke and ischemic heart disease: A national longitudinal cohort study in Taiwan.
In conclusion, clinicians should be aware about evaluating the IHD risk following a heat stroke episode in a patient.
PMID: 30297250 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - October 5, 2018 Category: Internal Medicine Authors: Tseng MF, Chou CL, Chung CH, Chien WC, Chen YK, Yang HC, Chu P Tags: Eur J Intern Med Source Type: research
Urban-rural differences in risk factors for ischemic stroke in northern China
This study aims to investigate urban-rural differences in characteristics and risk factors of ischemic stroke in northern China.
The present cross-sectional study was based on the High-risk Population Screening and Intervention Project for Stroke. The cluster sampling method was used to select urban and rural screening sites in northern China. By collecting information and screening the data, patients with ischemic stroke were obtained and a control group with similar gender, age, and regional distribution was selected among the nonischemic stroke patients. Then, the demographic and risk factors of patients with ischemic ...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Comparative Effectiveness of Blood Pressure-lowering Drugs in Patients who have Already Suffered From Stroke: Traditional and Bayesian Network Meta-analysis of Randomized Trials
Abstract: Hypertension is the most important risk factor for stroke and stroke recurrence. However, the preferred blood pressure (BP)-lowering drug class for patients who have suffered from a stroke has yet to be determined.
To investigate the relative effects of BP-lowering therapies [angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blockers (ARB), β blockers, calcium channel blockers (CCBs), diuretics, and combinations of these drugs] in patients with a prior stroke history, we performed a systematic review and meta-analysis using both traditional frequentist and Bayesian random-effects models and m...
Source: Medicine - April 1, 2016 Category: Internal Medicine Tags: Research Article: Systematic Reviewand Meta-Analysis Source Type: research
A nonlinear association between resting heart rate and ischemic stroke among community elderly hypertensive patients.
Conclusions: In Chinese elderly hypertensive patients, elevated resting heart rate was an independent predictor of ischemic stroke, and the optimal resting heart rate was around 70bpm.
PMID: 31829063 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - December 13, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research
Association of beta-2-microglobulin, cystatin C and lipocalin-2 with stroke risk in the general Chinese population
CONCLUSION: Elevated serum B2M, cystatin C and LCN-2 levels are associated with stroke risk. They may be novel biomarkers for clinicians to assess stroke risk.Key messagesSerum beta-2-microglobulin, cystatin C and lipocalin-2 levels are significantly associated with stroke risk.Beta-2-microglobulin, cystatin C and lipocalin-2 may serve as useful biomarkers for stroke risk stratification in the general population.PMID:37155257 | DOI:10.1080/07853890.2023.2203516
Source: Annals of Medicine - May 8, 2023 Category: Internal Medicine Authors: Juanying Zhen Shuyun Liu Ryan Yan Lam Kam Guoru Zhao Hao Peng Jianguo Liang Aimin Xu Chao Li Lijie Ren Jun Wu Bernard Man Yung Cheung Source Type: research
Exaggerated exercise blood pressure response and risk of stroke in patients referred for stress testing.
CONCLUSION: We did not observe any significant association between exercise SBP and the future occurrence of stroke in patients with known or suspected CAD referred for exercise echocardiography.
PMID: 24930070 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - June 11, 2014 Category: Internal Medicine Authors: Bouzas-Mosquera MD, Bouzas-Mosquera A, Peteiro J, Broullón FJ, Alvarez-García N, Castro-Beiras A Tags: Eur J Intern Med Source Type: research
Pregnancy increases stroke risk up to 1 year postpartum and reduces long-term risk
Conclusion: The risk of stroke was elevated during the first year postpartum, but lower in subsequent years. Stroke risk increased in multiparous ( ≥3) women. Physicians should be on alert for pregnancy complications and ensure appropriate management to prevent postpartum stroke.
Source: QJM - January 9, 2017 Category: Internal Medicine Source Type: research
Validation of the R2CHADS2 and CHADS2 Scores for Predicting Post-stroke Cognitive Impairment.
Conclusion These results suggest that the R2CHADS2 and CHADS2 scores are useful for predicting post-stroke cognitive impairment.
PMID: 28924104 [PubMed - as supplied by publisher]
Source: Internal Medicine - September 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research
The association between serum uric acid levels and ischemic stroke in essential hypertension patients.
Conclusions: SUA was an independent risk factor for ischemic stroke, and also have a good predictive value ischemic stroke among hypertensive patients in Chinese community.
PMID: 32303139 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - April 19, 2020 Category: Internal Medicine Tags: Postgrad Med Source Type: research
