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Specialty: Drugs & Pharmacology
Condition: Hypertension

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Total 409 results found since Jan 2013.

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Caveolin-1 in stroke neuropathology and neuroprotection: a novel molecular therapeutic target for ischemic-related injury.
Abstract Cardiovascular disease and associated cerebral stroke are a global epidemic attributed to genetic and epigenetic factors, such as diet, life style and an increasingly sedentary existence due to technological advances in both the developing and developed world. There are approximately 5.9 million stroke-related deaths worldwide annually. Current epidemiological data indicate that nearly 16.9 million people worldwide suffer a new or recurrent stroke yearly. In 2014 alone, 2.4% of adults in the United States (U.S.) were estimated to experience stroke, which is the leading cause of adult disability and the fi...
Source: Current Vascular Pharmacology - February 5, 2018 Category: Drugs & Pharmacology Authors: Wang S, Head BP Tags: Curr Vasc Pharmacol Source Type: research

A Combination of Atorvastatin and Aspirin Enhances the Pro-Regenerative Interactions of Marrow Stromal Cells and Stroke-Derived Monocytes In Vitro
Conclusion: Atorvastatin, alone and in combination with aspirin can promote anti-inflammatory effect by modulating the secretome profile of Mo and MSCs. Our results suggest that stroke trials involving the use of intravenous MSCs should consider the effect of aspirin and atorvastatin, both of which are administered to the majority of hospitalized ischemic stroke patients.
Source: Frontiers in Pharmacology - April 20, 2021 Category: Drugs & Pharmacology Source Type: research

Association of High Homocysteine Levels With the Risk Stratification in Hypertensive Patients at Risk of Stroke.
Abstract PURPOSE: We aimed to investigate the association between stroke morbidity and different stratifications of classic risk factors, such as increasing age, body mass index (BMI), blood lipids, and blood glucose, in hypertensive patients with high homocysteine levels. METHODS: A cross-sectional study of 2258 patients with primary hypertension were enrolled in this study, including 871 stroke cases (62.89%) in 1385 hypertensive patients without hyperhomocysteinemia (HHcy) and 647 (74.11%) stroke cases in 873 hypertensive patients with HHcy. Basic information of patients were collected, including age, sex,...
Source: Clinical Therapeutics - March 23, 2016 Category: Drugs & Pharmacology Authors: Pang H, Han B, Fu Q, Zong Z Tags: Clin Ther Source Type: research

Colony-Stimulating Factors on Mobilizing CD34+ Cells and Improving Neurological Functions in Patients With Stroke: A Meta-Analysis and a Systematic Review
Conclusion: Our study consolidates the security of CSF administration for its exerting no effect on detrimental outcomes. It has proven to be effective in elevating CD34+ cell counts in periphery blood at day 5, indicating CSF may participate in stroke recovery, but its efficacy in stroke recovery remains detected.
Source: Frontiers in Pharmacology - July 22, 2021 Category: Drugs & Pharmacology Source Type: research

Molecular genetics of coronary artery disease and ischemic stroke
Publication date: Available online 30 April 2015 Source:Personalized Medicine Universe Author(s): Yoshiji Yamada Coronary artery disease (CAD) and ischemic stroke are important clinical problems because they are associated with high mortality rates. The main causal and treatable risk factors of CAD and ischemic stroke include hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, and smoking. In addition, recent studies have highlighted the importance of genetic factors and their interactions with environmental factors in the development of CAD and ischemic stroke. Disease prevention is an important strat...
Source: Personalized Medicine Universe - May 1, 2015 Category: Drugs & Pharmacology Source Type: research

Previously undiagnosed risk factors and medication nonadherence are prevalent in young adults with first ‐ever stroke
ConclusionsPreviously undiagnosed hypertension and nonadherence to treatment of hypertension and diabetes were more prevalent in young adult patients with first‐ever stroke in Taiwan. Interventions targeting young people to promote early detection and adequate control of VRFs should be encouraged.
Source: Pharmacoepidemiology and Drug Safety - July 1, 2017 Category: Drugs & Pharmacology Authors: Sheng ‐Feng Sung, Edward Chia‐Cheng Lai, Darren Philbert Wu, Cheng‐Yang Hsieh Tags: ORIGINAL REPORT Source Type: research

Stroke in a Young Woman as a Presenting Manifestation of Membranous Nephropathy
Stroke is one of the most severe complications of nephrotic syndrome (NS), only a few cases have been reported in previous literature. Some of those cases are not clear about whether the stroke was purely caused by NS because they also had other risk factors for stroke, such as old age, hypertension. A recent study showed that serum albumin less than 2.8 g/dL is a risk factor for thromboembolic events (venous thromboembolic events). Anticoagulation is suggested for patients with NS with low albumin by KIDIGO guideline 2012. Here, we describe a case in which a young patient presented with stroke as an initial symptom of mem...
Source: American Journal of Therapeutics - May 1, 2016 Category: Drugs & Pharmacology Tags: Case Reports Source Type: research

Stroke and Hypertension: an Appraisal from Pathophysiology to Clinical Practice.
Abstract Stroke as a cause of long-term disability is a growing public health burden. Therefore, focusing on prevention is important. The most prominent aim of this strategy is to treat modifiable risk factors, such as arterial hypertension, the leading modifiable contributor to stroke. Thus, efforts to adequately reduce blood pressure (BP) among hypertensives are mandatory. In this respect, although safety and benefits of BP control related to long-term outcome have been largely demonstrated, there are open questions that remain to be addressed, such as optimal timing to initiate BP reduction and BP goals to be t...
Source: Current Vascular Pharmacology - November 16, 2017 Category: Drugs & Pharmacology Authors: Buonacera A, Stancanelli B, Malatino L Tags: Curr Vasc Pharmacol Source Type: research

Uric acid treatment after stroke modulates the Kr üppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: impact of hypertension.
Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: impact of hypertension. Biochem Pharmacol. 2019 Apr 04;: Authors: Vila E, Solé M, Masip N, Puertas-Umbert L, Amaro S, Paula Dantas A, Unzeta M, D'Ocon P, Maria Planas A, Chamorro Á, Jiménez-Altayó F Abstract Uric acid (UA) is a promising protective treatment in ischaemic stroke, but the precise molecular targets underlying its in vivo beneficial actions remain unclear. High concentrations of UA inhibit angiogenesis of cultured endothelial cells via Krüppel-like factor 2 (...
Source: Biochemical Pharmacology - April 3, 2019 Category: Drugs & Pharmacology Authors: Vila E, Solé M, Masip N, Puertas-Umbert L, Amaro S, Paula Dantas A, Unzeta M, D'Ocon P, Maria Planas A, Chamorro Á, Jiménez-Altayó F Tags: Biochem Pharmacol Source Type: research

Systolic hypertension related single nucleotide polymorphism is associated with susceptibility of ischemic stroke.
CONCLUSIONS: Our study suggests that genetic variants in systolic pressure-related genotypes may contribute to the etiology of ischemic stroke. PMID: 28682427 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 7, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Long Noncoding RNAs as Diagnostic and Therapeutic Targets for Ischemic Stroke.
Abstract LncRNAs (long non-coding RNAs) are endogenous molecules lacking protein-encoding capacity, which have been identified as key regulators of ischemic stroke. Increasing evidence suggests that lncRNAs play critical roles in several aspects of ischemic stroke, including atherosclerosis, dyslipidemia, hypertension, and diabetes mellitus. Hence, lncRNAs may further broaden our understanding of stroke pathogenesis. Altered lncRNA expression has been found in rodent focal cerebral ischemia models and oxygen-glucose deprived mouse brain microvascular endothelial cells as well as stroke patients. LncRNAs are consid...
Source: Current Pharmaceutical Design - March 26, 2019 Category: Drugs & Pharmacology Authors: Wang Q, Liu X, Zhu R Tags: Curr Pharm Des Source Type: research

Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats
ConclusionsAll results showed that ESL can play a therapeutic role in treating ischemic stroke through different pathways. This study will provide an overall view of the mechanism underlying the action of ESL against ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - May 23, 2019 Category: Drugs & Pharmacology Source Type: research

Prospective Study About the Relationship Between CEUS of Carotid Intraplaque Neovascularization and Ischemic Stroke in TIA Patients
Conclusion For carotid plaques, CEUS could evaluate the infusion mode of them, which could reflect the neovascularization in plaques. CEUS could predict the incurrence of ischemic stroke or recurrence of TIA in TIA patients, which was useful information for clinical decision.
Source: Frontiers in Pharmacology - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

CYP2C19 Loss-of-Function Variants Associated with Long-term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population
This study aims to determine whether CYP2C19 loss-of-function (LoF) variants were associated with long-term ischemic stroke risk in Chinese primary care patients treated with clopidogrel. Patients treated with clopidogrel were ascertained from a Chinese Electronic Medical Record linked with biobank for a retrospective cohort study. Their medical information was examined for the period from January 2018 to December 2021. Two CYP2C19 major loss of function variants (*2:rs4244285, *3: rs4986893) were genotyped. The clinical outcome was ischemic stroke event. Cox regression analysis was used to evaluate the association between...
Source: Clinical Pharmacology and Therapeutics - August 22, 2023 Category: Drugs & Pharmacology Authors: Peng Wu Ziqing Liu Zijian Tian Benrui Wu Jian Shao Qian Li Zhaoxu Geng Ying Pan Ke Lu Qiang Wang Tao Xu Kaixin Zhou Source Type: research