Lentiviral vector-mediated gene transfer combined with cisplatin enhances tumor suppression in human bladder cancer cell lines
ConclusionLentiviral vector-mediated gene transduction is a promising alternative to the existing therapy in treating bladder cancer. The current protocol of CDDP-based chemotherapy may be replaced in the future. Moreover, the combination of gene therapy and chemotherapy may be an effective treatment for bladder cancer. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - June 29, 2019 Category: Drugs & Pharmacology Source Type: research

A case of refractory serum sodium disorders with severe multiple trauma
Publication date: Available online 21 June 2019Source: Personalized Medicine UniverseAuthor(s): Kasumi Satoh, Tomoki Furuya, Manabu Okuyama, Hajime NakaeAbstractA 40-year-old man was admitted to the hospital with multiple injuries, including head injury and his laboratory results were significant for sodium abnormalities. Initially, hypernatremia was from increased sodium intake. Subsequently, hyponatremia developed that was unresponsive to sodium supplementation. Syndrome of inappropriate antidiuretic hormone secretion or cerebral salt wasting syndrome was suspected. Additional tests suggested post-traumatic hypopituitari...
Source: Personalized Medicine Universe - June 23, 2019 Category: Drugs & Pharmacology Source Type: research

Investigation of diffusion, practical use, and utility of a medical device for Japanese hemophilia patients in a single institution
ConclusionThough personalized treatment can be formalized to some extent, it is expected that medical treatment skills and management by tacit knowledge are affected in individualized treatment based on standardized treatment. Medical institutions and medical staff are the main body sharing and deploying measures to disseminate and utilize medical devices, cooperating with them can be an effective management of standardized and individualized treatment. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - June 23, 2019 Category: Drugs & Pharmacology Source Type: research

Lifestyle medicine – An evidence based approach to nutrition, sleep, physical activity, and stress management on health and chronic illness
Publication date: Available online 18 June 2019Source: Personalized Medicine UniverseAuthor(s): Minako Abe, Hiroyuki AbeAbstractLifestyle-related chronic illnesses, such as metabolic syndrome, type 2 diabetes, cancer, and dementia are rising at an alarming, epidemic rate. In this modern world of increasing lifespan, we are actually decreasing our health span, placing an undue burden on healthcare costs to society. Modern medicine has largely gotten away from addressing key issues to prevent or even reverse some of these chronic conditions. Yet the evidence for successful interventions in four key areas – nutrition, s...
Source: Personalized Medicine Universe - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

CTCs as tumor antigens: A pilot study using ex-vivo expanded tumor cells to be used as lysate for DC vaccines
Publication date: Available online 14 June 2019Source: Personalized Medicine UniverseAuthor(s): Ayaka Nakamura, Minako Abe, Yasuha Ono, Yukie Saeki, Fumika Kono, Hazuki Sakuma, Ayumi Morokuma, Yoshimori Ishihara, Hiroyuki AbeAbstractThe global incidence and mortality rates of colorectal cancer is rising, and has surpassed lung cancer as the highest incidence of all types of cancers in Japan [1]. Standard treatments include surgery and chemotherapy, however immunotherapy using Dendritic Cell (DC) vaccines is also recognized as an effective treatment for many cancers including colorectal cancer. DCs are the most potent antig...
Source: Personalized Medicine Universe - June 16, 2019 Category: Drugs & Pharmacology Source Type: research

Personalized care using thermobalancing therapy can help men with chronic prostatitis and chronic pelvic pain to recover
Publication date: Available online 18 May 2019Source: Personalized Medicine UniverseAuthor(s): Simon AllenAbstractIntroductionThe incidence of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is high. Thermobalancing therapy (TT) with Dr Allen's Therapeutic Device (DATD) improves the condition of men with CP/CPPS by treating the cause of this disease. The aim of this study is to improve management of CP/CPPS.MethodsA clinical trial observed the dynamics of clinical characteristics and parameters in 45 men with CP/CPPS who used DATD, before and after a 6-month period of therapy, and in a no-treatment group. Evalua...
Source: Personalized Medicine Universe - May 18, 2019 Category: Drugs & Pharmacology Source Type: research

A proposed simple screening method to determine relative contributions of CYP3A4 and CYP3A5 to drug metabolism in vitro
ConclusionsThrough the establishment of our screening method in the present study, we are sure it is useful to determine the relative contributions of CYP3A4 and CYP3A5 to drug metabolism in vitro. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lentiviral vector-mediated transfection of p53, p16 and PTEN genes against human renal cell carcinoma cell lines
ConclusionsThe results of this study demonstrate that lentivirus-mediated transfection of tumor suppressor genes exerts promising anti-tumor effects on RCC cell lines. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Changes of blood myokine levels following human skeletal muscle contraction using belt electrode skeletal muscle electrical stimulation
In this study, we investigated whether high sensitivity C-reactive protein, IL-6, and the anti-inflammatory cytokine, IL-10, were produced in humans by muscle contraction due to electrical stimulation. Six healthy men underwent 20 min of belt electrode skeletal muscle electrical stimulation. No time-dependent changes in IL-6, IL-10, and high sensitivity C-reactive protein were observed. These results suggest that blood myokines do not increase in response to standard electrical stimulation. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of oral consumption of Panax ginseng aqueous extract on natural killer cell cytotoxicity in humans
ConclusionOral intake of 1000 mg of PgE for two weeks significantly augmented NK cell cytotoxicity over that observed with the placebo. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - October 9, 2018 Category: Drugs & Pharmacology Source Type: research

Diagnosis and treatment in the era of precision medicine – Precision medicine and tailor-made medicine
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Masayoshi Nagata, Shigeo HorieAbstractRecently, precision medicine has gained attention in several fields of medical society. Today's medical consensus revolves around Evidence-Based Medicine (EBM) built on the results of many randomized controlled trials. Ever since the advent of EBM, guidelines based on EBM have provided a basis for clinical decision-making. Treatments based on these guidelines largely improved the prognosis of a certain ailment. However, these guidelines can only provide the best fit based on the statistics. Treatments...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

DNA methylation analysis of cancer-related genes from cell-free DNA of patients with cancer
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Yukie Saeki, Minako Abe, Fumika Kono, Akane Nakazato, Yoshimori Ishihara, Hiroyuki AbeAbstractDNA methylation is a very important mechanism for regulating gene expression in normal development and cell differentiation. However, DNA methylation, when acting on the promoter region of a tumor suppressor gene, suppresses transcription and is one of the major epigenetic modifications involved in the development and progression of many cancers (Wajed et al., 2001; Morris and Chan 2015). In our laboratory, we have carried out methylation an...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Chlorogenic acid modulates hypoxia response of Hep3B cells
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Ferbian Milas Siswanto, Ami Oguro, Susumu ImaokaAbstractCoffee is the most widely consumed beverage around the world, and it contains many compounds that have beneficial effects on human health. Chlorogenic acid (CGA), the most abundant polyphenol in coffee, has been reported to inhibit cancer cell growth and has a beneficial effect on ameliorating aging-related diseases. We found that CGA decreased HIF-1α levels in human hepatoma cell line Hep3B under hypoxic conditions (O2 = 1%) in a dose-dependent manner, thereby decrea...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of a compound supplement containing glucosamine, chondroitin, and five bioactive ingredients in volunteers with knee joint pain
ConclusionThese findings suggest that the compound supplementation of functional food ingredients has potential as an adjunctive and safe therapy for knee OA. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Oral administration of freeze-dried powders of honey bee larvae inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice
ConclusionsOur results indicate that oral administration of the freeze-dried honey bee larvae powder could provide an adjunctive therapy for the management of AD. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

A case of advanced ovarian cancer effectively treated with a combination of multi-peptide dendritic cell immunotherapy, surgery, and chemotherapy
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Amane Sasada, Minako Abe, Hiroyuki Abe (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Detection of aberrant DNA methylation of tumor suppressor genes in circulating tumor cells from a pancreatic cancer patient
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Hiroaki Kawasaki, Hiroyuki Abe (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Gap in perception regarding recovery between patients and nurses in recovery-stage rehabilitation ward
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Masumi Kumada, Miki Matsunami (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical study of the efficacy of a yeast containing S-adenosyl methionine on knee osteoarthritis
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Yukio Mitsui, Maki Satou, Shinichi Shimizu, Hiroshi Mitsui, Hirohiko Matsumoto (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

On molecularly personalized medicine clinical trials
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Reza Sanaye, Babak Daneshfard (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Personalized medicine for connective tissue disease: Historical and future perspectives
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Masataka KuwanaAbstractConnective tissue disease (CTD), previously termed collagen disease, is a group of disorders, characterized by rheumatic symptoms, autoimmunity, and degeneration of the pathohistology of the extracellular matrix. Better classification and disease subsetting, as well as introduction of immunosuppressants and molecular-targeting drugs, have much improved patients' quality of life and prognosis. The treat-to-target strategy in combination with emphasis on early diagnosis and intervention is now advocated for many CTDs....
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Cloning and expansion of antigen-specific T cells using iPS cell technology: Possible use of regenerated T cells in personalized medicine
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Hiroshi Kawamoto, Kyoko Masuda, Seiji NaganoAbstractRecent advances in adoptive immunotherapy using cytotoxic T lymphocytes (CTLs) have demonstrated that CTLs are effective in killing tumor cells in vivo for some tumor types. However, a critical issue that CTLs collected from patients are easily exhausted during expansion culture is yet to be addressed. Therefore, we have been developing a strategy that utilizes induced pluripotent stem cell (iPSC) technology, based on the idea that iPSCs produced from antigen-specific CTLs would reg...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Significance of humanized mouse models for evaluating humoral immune response against cancer vaccines
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Yoshie Kametani, Asuka Miyamoto, Toshiro Seki, Ryoji Ito, Sonoko Habu, Yutaka TokudaAbstractBecause accumulation of mutations produces unique neoantigen patterns in cancer cells, it has been hypothesized that these patterns are recognized by the patients' immune system. Therefore, the development of cancer vaccines has been challenging owing to the possibility of an anti-cancer effect induced by the immune system against such neoantigens. However, it is difficult to develop effective vaccines because of the variety of mutations induced in...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Association of MTHF 677TT with adverse drug reactions and RFC G80A with non-response and adverse drug reactions in methotrexate therapy
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Manahel Mahmood AlSabbaghAbstractBeing an anti-metabolite and anti-inflammatory agent, Methotrexate, a folate analogue, is indicated for a wide spectrum of diseases including moderate to severe chronic inflammatory disorders like psoriasis and rheumatoid arthritis and malignant diseases such as childhood acute lymphoblastic leukaemia and choriocarcinoma. The outcome of Methotrexate treatment varies. Though up to 50% of patients with inflammatory disorders show a favourable response; one third discontinues Methotrexate due to adverse drug ...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Assessing antitumor and T cell immune responses by cytokine assay in cancer patients treated with immunotherapy – A pilot study
We examined the usefulness of this method as a biomarker to assess the therapeutic effectiveness of immune cell therapy by statistical analysis and by plotting a cancer immunogram correlating patient data with clinical outcomes. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Predictive factors for the development of bronchial asthma by the age of 3
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Naomi Kondo, Eiko Matsui, Takahide Teramoto, Manami Kuwabara, Tomiko Nagata, Yayoi Furuta, Masayo Sanada, Ikuko Aoki, Masumi KumadaAbstractThe relationship between several factors at 1.5 years of age and the development of bronchial asthma by 3 years of age was investigated. The factors that were found to be related to the development of bronchial asthma were identified and listed as predictive factors for the development of bronchial asthma by the age of 3. As a result, a parent or a sibling with bronchial asthma, a history of wheezing w...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Current state and issues related to cell therapy under the Act on the Safety of Regenerative Medicine
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Morikuni TobitaAbstractIn May the 2013, Regenerative Medicine Promotion Act was enacted in order to promote regenerative medicine in Japan. Based on this Act, in November 2014, the Act on the Safety of Regenerative Medicine, which ensured the safety of regenerative medicine, was put into effect. The Act on the Safety of Regenerative Medicine was intended to promote the swift and safe provision and promulgation of regenerative medicine, and it applies to both clinical research and private practice that utilizes regenerative medicine.In thi...
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Novel biologic products and Post-Bio strategy
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Kusuki Nishioka (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Diagnosis and treatment in the era of precision medicine – Precision medicine and tailor-made medicine
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Masayoshi Nagata, Shigeo HorieAbstractRecently, precision medicine has gained attention in several fields of medical society. Today's medical consensus revolves around Evidence-Based Medicine (EBM) built on the results of many randomized controlled trials. Ever since the advent of EBM, guidelines based on EBM have provided a basis for clinical decision-making. Treatments based on these guidelines largely improved the prognosis of a certain ailment. However, these guidelines can only provide the best fit based on the statistics. Treatments...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

DNA methylation analysis of cancer-related genes from cell-free DNA of patients with cancer
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Yukie Saeki, Minako Abe, Fumika Kono, Akane Nakazato, Yoshimori Ishihara, Hiroyuki AbeAbstractDNA methylation is a very important mechanism for regulating gene expression in normal development and cell differentiation. However, DNA methylation, when acting on the promoter region of a tumor suppressor gene, suppresses transcription and is one of the major epigenetic modifications involved in the development and progression of many cancers (Wajed et al., 2001; Morris and Chan 2015). In our laboratory, we have carried out methylation an...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Chlorogenic acid modulates hypoxia response of Hep3B cells
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Ferbian Milas Siswanto, Ami Oguro, Susumu ImaokaAbstractCoffee is the most widely consumed beverage around the world, and it contains many compounds that have beneficial effects on human health. Chlorogenic acid (CGA), the most abundant polyphenol in coffee, has been reported to inhibit cancer cell growth and has a beneficial effect on ameliorating aging-related diseases. We found that CGA decreased HIF-1α levels in human hepatoma cell line Hep3B under hypoxic conditions (O2 = 1%) in a dose-dependent manner, thereby decrea...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of a compound supplement containing glucosamine, chondroitin, and five bioactive ingredients in volunteers with knee joint pain
ConclusionThese findings suggest that the compound supplementation of functional food ingredients has potential as an adjunctive and safe therapy for knee OA. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Oral administration of freeze-dried powders of honey bee larvae inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice
ConclusionsOur results indicate that oral administration of the freeze-dried honey bee larvae powder could provide an adjunctive therapy for the management of AD. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

A case of advanced ovarian cancer effectively treated with a combination of multi-peptide dendritic cell immunotherapy, surgery, and chemotherapy
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Amane Sasada, Minako Abe, Hiroyuki Abe (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Detection of aberrant DNA methylation of tumor suppressor genes in circulating tumor cells from a pancreatic cancer patient
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Hiroaki Kawasaki, Hiroyuki Abe (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Gap in perception regarding recovery between patients and nurses in recovery-stage rehabilitation ward
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Masumi Kumada, Miki Matsunami (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical study of the efficacy of a yeast containing S-adenosyl methionine on knee osteoarthritis
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Yukio Mitsui, Maki Satou, Shinichi Shimizu, Hiroshi Mitsui, Hirohiko Matsumoto (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

On molecularly personalized medicine clinical trials
Publication date: July 2017Source: Personalized Medicine Universe, Volume 6Author(s): Reza Sanaye, Babak Daneshfard (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Personalized medicine for connective tissue disease: Historical and future perspectives
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Masataka KuwanaAbstractConnective tissue disease (CTD), previously termed collagen disease, is a group of disorders, characterized by rheumatic symptoms, autoimmunity, and degeneration of the pathohistology of the extracellular matrix. Better classification and disease subsetting, as well as introduction of immunosuppressants and molecular-targeting drugs, have much improved patients' quality of life and prognosis. The treat-to-target strategy in combination with emphasis on early diagnosis and intervention is now advocated for many CTDs....
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Cloning and expansion of antigen-specific T cells using iPS cell technology: Possible use of regenerated T cells in personalized medicine
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Hiroshi Kawamoto, Kyoko Masuda, Seiji NaganoAbstractRecent advances in adoptive immunotherapy using cytotoxic T lymphocytes (CTLs) have demonstrated that CTLs are effective in killing tumor cells in vivo for some tumor types. However, a critical issue that CTLs collected from patients are easily exhausted during expansion culture is yet to be addressed. Therefore, we have been developing a strategy that utilizes induced pluripotent stem cell (iPSC) technology, based on the idea that iPSCs produced from antigen-specific CTLs would reg...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Significance of humanized mouse models for evaluating humoral immune response against cancer vaccines
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Yoshie Kametani, Asuka Miyamoto, Toshiro Seki, Ryoji Ito, Sonoko Habu, Yutaka TokudaAbstractBecause accumulation of mutations produces unique neoantigen patterns in cancer cells, it has been hypothesized that these patterns are recognized by the patients' immune system. Therefore, the development of cancer vaccines has been challenging owing to the possibility of an anti-cancer effect induced by the immune system against such neoantigens. However, it is difficult to develop effective vaccines because of the variety of mutations induced in...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Association of MTHF 677TT with adverse drug reactions and RFC G80A with non-response and adverse drug reactions in methotrexate therapy
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Manahel Mahmood AlSabbaghAbstractBeing an anti-metabolite and anti-inflammatory agent, Methotrexate, a folate analogue, is indicated for a wide spectrum of diseases including moderate to severe chronic inflammatory disorders like psoriasis and rheumatoid arthritis and malignant diseases such as childhood acute lymphoblastic leukaemia and choriocarcinoma. The outcome of Methotrexate treatment varies. Though up to 50% of patients with inflammatory disorders show a favourable response; one third discontinues Methotrexate due to adverse drug ...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Assessing antitumor and T cell immune responses by cytokine assay in cancer patients treated with immunotherapy – A pilot study
We examined the usefulness of this method as a biomarker to assess the therapeutic effectiveness of immune cell therapy by statistical analysis and by plotting a cancer immunogram correlating patient data with clinical outcomes. (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Predictive factors for the development of bronchial asthma by the age of 3
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Naomi Kondo, Eiko Matsui, Takahide Teramoto, Manami Kuwabara, Tomiko Nagata, Yayoi Furuta, Masayo Sanada, Ikuko Aoki, Masumi KumadaAbstractThe relationship between several factors at 1.5 years of age and the development of bronchial asthma by 3 years of age was investigated. The factors that were found to be related to the development of bronchial asthma were identified and listed as predictive factors for the development of bronchial asthma by the age of 3. As a result, a parent or a sibling with bronchial asthma, a history of wheezing w...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Current state and issues related to cell therapy under the Act on the Safety of Regenerative Medicine
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Morikuni TobitaAbstractIn May the 2013, Regenerative Medicine Promotion Act was enacted in order to promote regenerative medicine in Japan. Based on this Act, in November 2014, the Act on the Safety of Regenerative Medicine, which ensured the safety of regenerative medicine, was put into effect. The Act on the Safety of Regenerative Medicine was intended to promote the swift and safe provision and promulgation of regenerative medicine, and it applies to both clinical research and private practice that utilizes regenerative medicine.In thi...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Novel biologic products and Post-Bio strategy
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Kusuki Nishioka (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

Novel biologic products and Post-Bio strategy
Publication date: Available online 12 April 2018 Source:Personalized Medicine Universe Author(s): Kusuki Nishioka (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - April 13, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical study of the efficacy of a yeast containing S-adenosyl methionine on knee osteoarthritis
Publication date: July 2017 Source:Personalized Medicine Universe, Volume 6 Author(s): Yukio Mitsui, Maki Satou, Shinichi Shimizu, Hiroshi Mitsui, Hirohiko Matsumoto (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - July 11, 2017 Category: Drugs & Pharmacology Source Type: research

Diagnosis and treatment in the era of precision medicine – Precision medicine and tailor-made medicine
Publication date: Available online 23 June 2017 Source:Personalized Medicine Universe Author(s): Masayoshi Nagata, Shigeo Horie Recently, precision medicine has gained attention in several fields of medical society. Today's medical consensus revolves around Evidence-Based Medicine (EBM) built on the results of many randomized controlled trials. Ever since the advent of EBM, guidelines based on EBM have provided a basis for clinical decision-making. Treatments based on these guidelines largely improved the prognosis of a certain ailment. However, these guidelines can only provide the best fit based on the statistics. Treat...
Source: Personalized Medicine Universe - June 24, 2017 Category: Drugs & Pharmacology Source Type: research

Detection of aberrant DNA methylation of tumor suppressor genes in circulating tumor cells from a pancreatic cancer patient
Publication date: Available online 2 June 2017 Source:Personalized Medicine Universe Author(s): Hiroaki Kawasaki, Hiroyuki Abe (Source: Personalized Medicine Universe)
Source: Personalized Medicine Universe - June 2, 2017 Category: Drugs & Pharmacology Source Type: research