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Condition: Hypertension
Nutrition: Calcium

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Total 337 results found since Jan 2013.

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice
Hypertension in the elderly substantially increases the risk of stroke and vascular cognitive impairment in part due to an impaired functional adaptation of aged cerebral arteries to high blood pressure. To elucidate the mechanisms underlying impaired autoregulatory protection in aging, hypertension was induced in young (3 mo) and aged (24 mo) C57BL/6 mice by chronic infusion of angiotensin II and pressure-induced changes in smooth muscle cell (SMC) intracellular Ca2+ concentration ([Ca2+]i) and myogenic constriction of middle cerebral arteries (MCA) were assessed. In MCAs from young hypertensive mice, pressure-induced inc...
Source: AJP: Heart and Circulatory Physiology - December 15, 2013 Category: Cardiology Authors: Toth, P., Csiszar, A., Tucsek, Z., Sosnowska, D., Gautam, T., Koller, A., Schwartzman, M. L., Sonntag, W. E., Ungvari, Z. Tags: CALL FOR PAPERS Source Type: research

Lower dairy products and calcium intake is associated with adverse retinal vascular changes in older adults
Conclusions: A significant association was observed between lower intake of dairy products or calcium and adverse retinal vascular signs. We cannot discount the possibility of confounding from unmeasured risk factors; hence, further studies are warranted to confirm these findings.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 13, 2014 Category: Nutrition Authors: B. Gopinath, V.M. Flood, J.J. Wang, G. Burlutsky, P. Mitchell Tags: Electrolyte intake, blood pressure and vascular changes Source Type: research

Are Carotid Artery Stenosis-Isolated and Carotid Artery-Plus Two Distinct Entities? (P7.172)
CONCLUSIONS: CAS-isolated and CAS-plus appear to be two distinct entities with unique demographic and clinical attributes.Disclosure: Dr. Jani has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Jani, V., Malik, A., Hussain, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease Source Type: research

Statins do not improve cardiovascular outcomes for dialysis patients
Commentary on: Palmer SC, Navaneethan SD, Craig JC, et al.. HMG CoA reductase inhibitors (statins) for dialysis patients: a systematic review and meta-analysis. Cochrane Database Syst Rev 2013;(9):CD004289. Context Chronic kidney disease affected nearly 19 million people in the USA, with incidence increasing globally at an annual rate of 8%, most of which were unrecognised or undiagnosed. Cardiovascular events are common among patients with chronic kidney disease and highest in dialysis patients. While dialysis patients experience a high prevalence of traditional risk factors for cardiovascular disease (CVD), such as hyper...
Source: Evidence-Based Medicine - May 19, 2014 Category: Internal Medicine Authors: Olyaei, A. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Neuromuscular disease, Stroke, Hypertension, Obesity (nutrition), Ischaemic heart disease, Unwanted effects / adverse reactions, Renal medicine, Musculoskeletal syndromes Source Type: research

Blood pressure control and cardiovascular outcomes in normal-weight, overweight, and obese hypertensive patients treated with three different antihypertensives in ALLHAT
Objective:Epidemiologically, there is a strong relationship between BMI and blood pressure (BP) levels. We prospectively examined randomization to first-step chlorthalidone, a thiazide-type diuretic; amlodipine, a calcium-channel blocker; and lisinopril, an angiotensin-converting enzyme inhibitor, on BP control and cardiovascular outcomes in a hypertensive cohort stratified by baseline BMI [kg/m2; normal weight (BMI 30)]. Methods:In a randomized, double-blind, practice-based Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, 33 357 hypertensive participants, aged at least 55 years, were followed...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research

The Relationship Between Nocturnal Blood Pressure and Hemorrhagic Stroke in Chinese Hypertensive Patients
To study the relationship between nocturnal blood pressure (BP) variation and spontaneous intracerebral hemorrhage (ICH) among Chinese hypertensive patients and its clinical significance, the authors retrospectively screened 371 patients with primary hypertension (189 patients with ICH, 182 patients without ICH) in Shanghai and analyzed their demographics, clinical information, nocturnal blood pressure variability and medication. Compared with the control group, the levels of blood glucose, triglycerides, and creatinine were significantly increased in the ICH group, along with a marked reduction in nocturnal BP drop (P<...
Source: The Journal of Clinical Hypertension - July 24, 2014 Category: Cardiology Authors: Jialan Sun, Wanlin Yang, Yang Zhu, Xiaohong Liu, Xin Wei, Baisong Wang, Jiuchang Zhong, Yi Fu Tags: Original Paper Source Type: research

Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial1
Conclusion:Despite no significant difference in cardiovascular events, the different safety profiles suggest that the combination of olmesartan and CCB may be preferable to that of olmesartan and diuretic.
Source: Journal of Hypertension - September 10, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Randomized controlled trial Source Type: research

Clevidipine: A Review of Its Use for Managing Blood Pressure in Perioperative and Intensive Care Settings
In conclusion, intravenous clevidipine is a valuable agent for the management of BP in perioperative and intensive care settings.
Source: Drugs - October 14, 2014 Category: Drugs & Pharmacology Source Type: research

Challenges in the management of hypertension in Asia
Hypertension is common in Asian populations and is a major cause of cardiovascular diseases. Even a small reduction in blood pressure can lead to a substantial decrease in the risk of stroke. The prevalence of hypertension appears to be increasing in many countries, partly because of ageing of the population, but also because of increasing obesity. While much effort has gone into promoting the awareness of hypertension, the rates of detection, treatment, and control remain low. As hypertension is very prevalent in the general population, it makes sense to adopt population approaches towards the detection and treatment of h...
Source: European Journal of Heart Failure Supplements - February 23, 2012 Category: Cardiology Authors: Cheung, B. M. Y., Cheung, T. T. Tags: Original Articles Source Type: research

Bedtime Hypertension Chronotherapy: Concepts and Patient Outcomes.
Abstract Recent findings indicate cardiovascular disease (CVD) risk is best predicted by asleep systolic blood pressure (SBP), and lowering it by scheduling ≥1 conventional long-acting hypertension medications, alone or in combination, at bedtime significantly lessens vascular-associated risks. Some 20 years ago, four controlled-onset extended-release drug-delivery systems incorporating a calcium channel blocker or β-blocker, with the treatment goal specifically being attenuation of morning rather than asleep BP, were conceived as one type of bedtime hypertension chronotherapy. However, the CONVINCE outcomes tr...
Source: Current Pharmaceutical Design - October 24, 2014 Category: Drugs & Pharmacology Authors: Smolensky MH, Hermida RC, Ayala DE, Portaluppi F Tags: Curr Pharm Des Source Type: research

Biomarkers of cardiovascular disease risk in women
Cardiovascular disease (CVD), including coronary heart disease and stroke, is the leading cause of death among U.S. women and men. Established cardiovascular risk factors such as smoking, diabetes, hypertension, and elevated total cholesterol, and risk prediction models based on such factors, perform well but do not perfectly predict future risk of CVD. Thus, there has been much recent interest among cardiovascular researchers in identifying novel biomarkers to aid in risk prediction. Such markers include alternative lipids, B-type natriuretic peptides, high-sensitivity troponin, coronary artery calcium, and genetic markers.
Source: Metabolism - Clinical and Experimental - October 29, 2014 Category: Biomedical Science Authors: JoAnn E. Manson, Shari S. Bassuk Source Type: research

Pulse Pressure Is Useful for Determining the Choice of Antihypertensive Drugs in Postmenopausal Women
Objective: To assess the efficacy of various classes of antihypertensive drugs in postmenopausal women with hypertension using pulse pressure (PP) as an index. Patients and Methods: Selected women were required to be naturally menopausal for at least 1 year but not more than 5 years past their menstrual period. Exclusion criteria were a history of preeclampsia or eclampsia, a severe illness such as myocardial infarction or stroke within 6 months, the use of estrogens or progestins within 3 months, proteinuric nephropathy, and surgically induced menopause. There were 114 women who participated in this study after having giv...
Source: Pulse - November 6, 2014 Category: Cardiology Source Type: research

Peroxisome Proliferator-activated Receptor-γ Agonist Pioglitazone Ameliorates White Matter Lesion and Cognitive Impairment in Hypertensive Rats.
CONCLUSIONS: Long-term treatment of pioglitazone has beneficial effect on hypertension-induced WML and cognition decline, which may partly through its effect on attenuation of arteriolar remodeling, endothelial activation, and brain inflammation. PMID: 25611692 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 22, 2015 Category: Neuroscience Authors: Lan LF, Zheng L, Yang X, Ji XT, Fan YH, Zeng JS Tags: CNS Neurosci Ther Source Type: research

Vitamin D deficiency and atrial fibrillation
Vitamin D deficiency has been linked with hypertension, coronary artery disease, and stroke, but there is no consensus regarding the possible association between vitamin D deficiency and atrial fibrillation (AF). Vitamin D negatively regulates the renin–angiotensin–aldosterone-system (RAAS), mediates calcium homeostasis, binds to vitamin D receptors on cardiac myocytes, and has antioxidant properties that may reduce levels of reactive oxygen species (ROS) in the atria, which contribute to inflammation and proarrhythmic substrate formation.
Source: International Journal of Cardiology - February 10, 2015 Category: Cardiology Authors: Joseph Thompson, Rynda Nitiahpapand, Prashan Bhatti, Antonios Kourliouros Tags: Review Source Type: research

Volumetric analysis of central body fat accurately predicts incidence of diabetes and hypertension in adults
Conclusions Central body fat and BMI equally and highly predict incidence of hypertension and type 2 diabetes.
Source: BMC Obesity - February 25, 2015 Category: Eating Disorders and Weight Management Source Type: research