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Condition: Hypertension
Nutrition: Calcium

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Total 337 results found since Jan 2013.

Roots of < em > Astragalus propinquus < /em > Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia-Reperfusion Injury
CONCLUSION: RAP stimulation inhibited ferroptosis by regulating the expression of the key ferroptosis factors XCT, SLC3A2, GPX4, NRF2, HO-1, and IREB2. In conclusion, RAP regulates transmembrane iron transport and ferroptosis to improve CIRI.PMID:35958925 | PMC:PMC9363172 | DOI:10.1155/2022/7410865
Source: Evidence-based Complementary and Alternative Medicine - August 12, 2022 Category: Complementary Medicine Authors: Juan Chen Donglai Ma Jun Bao Ying Zhang Guoxing Deng Source Type: research

The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease
Clin Sci (Lond). 2022 Aug 31;136(16):1241-1255. doi: 10.1042/CS20210990.ABSTRACTArtery stenosis is a common cause of hypertension and stroke and can be due to atherosclerosis accumulation in the majority of cases and in a small fraction of patients to arterial fibromuscular dysplasia (FMD). Artery stenosis due to atherosclerosis is widely studied with known risk factors (e.g. increasing age, male gender, and dyslipidemia) to influence its etiology, including genetic factors. However, the causes of noninflammatory and nonatherosclerotic stenosis in FMD are less understood. FMD occurs predominantly in early middle-age women,...
Source: Atherosclerosis - August 31, 2022 Category: Cardiology Authors: Adrien Georges Nabila Bouatia-Naji Source Type: research

How Menopause Affects Cholesterol —And How to Manage It
Kelly Officer, 49, eats a vegan diet and shuns most processed foods. So, after a recent routine blood test revealed that she had high cholesterol, “I was shocked and upset,” she says, “since it never has been [high] in the past.” Officer is not alone. As women enter menopause, cholestrol levels jump—by an average of 10-15%, or about 10 to 20 milligrams per deciliter. (A healthy adult cholesterol range is 125-200 milligrams per deciliter, according to the National Library of Medicine.) This change often goes unnoticed amidst physical symptoms and the general busyness of those years. But, says D...
Source: TIME: Health - September 21, 2022 Category: Consumer Health News Authors: Katherine Harmon Courage Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news

Cardiovascular risk factors and mitral annular calcification in type 2 diabetes
Conclusions: Age, female gender, Caucasian race, and diabetes duration were associated with the presence and extent of MAC in T2DM subjects, independent of CAC, which was also strongly associated with MAC. These data suggest that additional mechanisms for MAC formation in diabetics may exist which are distinct from those related to generalized atherosclerosis and deserve further investigation.Highlights: ► Mitral annular calcification (MAC) associates with adverse cardiovascular outcomes. ► We quantified MAC by CT in a large diabetic cohort without kidney or heart disease. ► MAC was not associated with traditional ca...
Source: Atherosclerosis - January 14, 2013 Category: Cardiology Authors: Atif N. Qasim, Hashmi Rafeek, Suraj P. Rasania, Timothy W. Churchill, Wei Yang, Victor A. Ferrari, Saurabh Jha, Stephen M. Master, Claire K. Mulvey, Karen Terembula, Chris Dailing, Matthew J. Budoff, Steven M. Kawut, Muredach P. Reilly Tags: Imaging & Measurement of Vessel Health Source Type: research

Left Ventricular Global Function Index by Magnetic Resonance Imaging--A Novel Marker for Assessment of Cardiac Performance for the Prediction of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology/Population Science
Left ventricular (LV) function is generally assessed independent of structural remodeling and vice versa. The purpose of this study was to evaluate a novel LV global function index (LVGFI) that integrates LV structure with global function and to assess its predictive value for cardiovascular (CV) events throughout adult life in a multiethnic population of men and women without history of CV diseases at baseline. A total of 5004 participants in the Multi-Ethnic Study of Atherosclerosis underwent a cardiac magnetic resonance study and were followed up for a median of 7.2 years. The LVGFI by cardiac magnetic resonance was def...
Source: Hypertension - March 13, 2013 Category: Cardiology Authors: Mewton, N., Opdahl, A., Choi, E.-Y., Almeida, A. L. C., Kawel, N., Wu, C. O., Burke, G. L., Liu, S., Liu, K., Bluemke, D. A., Lima, J. A. C. Tags: Congestive, Risk Factors, Hypertrophy, CT and MRI Epidemiology/Population Science Source Type: research

The Effects of Hypertension on the Cerebral Circulation.
Abstract Maintenance of brain function depends on a constant blood supply. Deficits in cerebral blood flow are linked to cognitive decline, and they have detrimental effects on the outcome of ischemia. Hypertension causes alterations in cerebral artery structure and function that can impair blood flow particularly during an ischemic insult, or during periods of low arterial pressure. This review will focus on the historical discoveries, novel developments and knowledge gaps in: 1) hypertensive cerebral artery remodeling; 2) vascular function, with emphasis on myogenic reactivity and endothelium-dependent dilation;...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2013 Category: Physiology Authors: Pires PW, Dams Ramos CM, Matin N, Dorrance AM Tags: Am J Physiol Heart Circ Physiol Source Type: research

The effects of hypertension on the cerebral circulation
Maintenance of brain function depends on a constant blood supply. Deficits in cerebral blood flow are linked to cognitive decline, and they have detrimental effects on the outcome of ischemia. Hypertension causes alterations in cerebral artery structure and function that can impair blood flow, particularly during an ischemic insult or during periods of low arterial pressure. This review will focus on the historical discoveries, novel developments, and knowledge gaps in 1) hypertensive cerebral artery remodeling, 2) vascular function with emphasis on myogenic reactivity and endothelium-dependent dilation, and 3) blood-brain...
Source: AJP: Heart and Circulatory Physiology - June 15, 2013 Category: Cardiology Authors: Pires, P. W., Dams Ramos, C. M., Matin, N., Dorrance, A. M. Tags: REVIEWS Source Type: research

Effect of lower sodium intake on health: systematic review and meta-analyses
This is another article that supports the literature for reduction in salt intake for overall population health. This systematic further shows that not only does salt lower blood pressure, but there are no adverse effects on lipids, catecholamine levels of renal function. Furthermore, it is associated with lower risk of stroke and fatal coronary heart disease in adults. : Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis. Systematic Review: Vitamin D and C...
Source: Nephrology Now - July 15, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: General Nephrology Hypertension Source Type: research

Do higher dialysate calcium concentrations increase vascular stiffness in haemodialysis patients as measured by aortic pulse wave velocity?
Background: Haemodialysis patients have an increased prevalence of hypertension and risk of cardiovascular mortality and stroke. Higher dialysate calcium concentrations have been reported to cause both an acute and chronic increase in arterial stiffness. We therefore looked at changes in arterial stiffness in established haemodialysis patients to determine whether there was a threshold effect of dialysate calcium concentration linked to change in arterial stiffness. Methods: We performed pulse wave velocity measurements six months apart in patients dialysing with calcium concentrations of 1.0, 1.25, 1.35 and>=1.5 mmol/l. R...
Source: BMC Nephrology - September 8, 2013 Category: Urology & Nephrology Authors: Evangelia CharitakiAndrew Davenport Source Type: research

Electrolyte imbalance triggering relapse of inflammatory neuropathy
We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three–weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non–bloody diarrhoea with night sweats ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Keshavan, A., Gandhi, S., Lunn, M., Reilly, M. Tags: Neurogastroenterology, Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Stroke, Hypertension Association of British Neurologists (ABN) joint meeting with the Royal College Source Type: research

Role of 20-HETE,TRP channels & BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
Role of 20-HETE,TRP channels & BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. Am J Physiol Heart Circ Physiol. 2013 Oct 4; Authors: Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Laniado Schwartzman M, Sonntag WE, Ungvari ZI Abstract Hypertension in the elderly substantially increases the risk stroke and vascular cognitive impairment (VCI) in part due to an impaired functional adaptation of aged cerebral arteries to high blood pressure. To elucidate the mechanisms underlying impaired autoregulatory protec...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 4, 2013 Category: Physiology Authors: Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Laniado Schwartzman M, Sonntag WE, Ungvari ZI Tags: Am J Physiol Heart Circ Physiol Source Type: research

Abstract 70: Eplerenone Increases Dilation and the Diameter of Cerebral Penetrating Arterioles in Rats with Sustained Hypertension Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones
Hypertension is linked to dementia in humans, as well as remodeling and dysfunction in large cerebral arteries. The effects of hypertension on cerebral microvessels, such as penetrating arterioles (PenA), are still unknown. These arterioles are the bottlenecks bridging the pial circulation to the deep parenchymal microcirculation, and they are vital for neurovascular coupling and functional hyperemia. Mineralocorticoid receptor (MR) antagonism reverses hypertension-induced changes in large cerebral arteries. Thus, we hypothesized that MR antagonism will improve PenA dilation and structure in adult rats with sustained hyper...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Pires, P. W., Jackson, W. F., Dorrance, A. M. Tags: Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones Source Type: research