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Condition: Hypertension
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Total 232 results found since Jan 2013.

Apparent Treatment-Resistant Hypertension Among Stroke Survivors: A Transcontinental Study assessing impact of race and geography
CONCLUSIONS: Future studies are needed to investigate the contribution of socioeconomic disparities in the prevalence aTRH in those with African Ancestry to explore the long-term impact, and evaluate effective therapeutic interventions in this subpopulation.PMID:35366323 | DOI:10.1093/ajh/hpac046
Source: American Journal of Hypertension - April 2, 2022 Category: Cardiology Authors: Fred Stephen Sarfo Esther Olasoji Grant P Banfill Bruce Ovbiagele Alexis N Simpkins Source Type: research

Predictors of Good Clinical Outcome in Acute Stroke Patients Underwent Recanalization Therapy (P01.242)
CONCLUSIONS: NIHSS at admission, recanalization grade and early neurological improvement are independent predictors of clinical outcome in AIS patients underwent mechanical recanalization.Supported by: IGA MH CR grants NT/11386-5/2010, NT/11046-6/2010, NT/13498-4/2012.Disclosure: Dr. Skoloudik has nothing to disclose. Dr. Roubec has nothing to disclose. Dr. Kuliha has nothing to disclose. Dr. Herzig has received personal compensation for activities with Bayer, Boehringer Ingelheim Pharmaceuticals, Inc., and Gedeon Richter. Dr. Sanak has received personal compensation from Boehringer Ingelheim for serving on a scientific ad...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Skoloudik, D., Roubec, M., Kuliha, M., Herzig, R., Sanak, D., Prochazka, V., Hrbac, T. Tags: P01 Cerebrovascular Disease I Source Type: research

High blood pressure among blacks and young adults is focus of $11 million stroke prevention project
(University of California - San Francisco) A new $11 million grant to Kaiser Permanente Northern California and UC San Francisco will support a multifaceted research program aimed at lowering stroke risk among black populations and younger stroke victims by targeting high blood pressure, also known as hypertension.
Source: EurekAlert! - Social and Behavioral Science - June 19, 2013 Category: Global & Universal Source Type: news

Peer Review Practices for Evaluating Biomedical Research Grants: A Scientific Statement From the American Heart Association.
ovascular Surgery and Anesthesia; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; Council on Hypertension; Council on Quality of Care and Outcomes Research; and Stroke Council Abstract The biomedical research enterprise depends on the fair and objective peer review of research grants, leading to the distribution of resources through efficient and robust competitive methods. In the United States, federal funding agencies and foundations collectively distribute billions of dollars annually to support biomedical research. For the American Heart Association, a Peer Review Subc...
Source: Circulation Research - July 6, 2017 Category: Cardiology Authors: Liaw L, Freedman JE, Becker LB, Mehta NN, Liscum L, Peer Review Subcommittee of the American Heart Association National Research Committee; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Card Tags: Circ Res Source Type: research

Brain Bioenergetics in Chronic Hypertension: Risk Factor for Acute Ischemic Stroke
Biochem Pharmacol. 2022 Sep 27:115260. doi: 10.1016/j.bcp.2022.115260. Online ahead of print.ABSTRACTChronic hypertension is one of the key modifiable risk factors for acute ischemic stroke, also contributing to determine greater neurological deficits and worse functional outcome when an acute cerebrovascular event would occur. A tight relationship exists between cerebrovascular autoregulation, neuronal activity and brain bioenergetics. In chronic hypertension, progressive adaptations of these processes occur as an attempt to cope with the demanding necessity of brain functions, creating a new steady-state homeostatic cond...
Source: Biochemical Pharmacology - September 30, 2022 Category: Drugs & Pharmacology Authors: Ferrari Federica Villa Roberto Federico Source Type: research

Brain bioenergetics in chronic hypertension: Risk factor for acute ischemic stroke
Biochem Pharmacol. 2022 Sep 28;205:115260. doi: 10.1016/j.bcp.2022.115260. Online ahead of print.ABSTRACTChronic hypertension is one of the key modifiable risk factors for acute ischemic stroke, also contributing to determine greater neurological deficits and worse functional outcome when an acute cerebrovascular event would occur. A tight relationship exists between cerebrovascular autoregulation, neuronal activity and brain bioenergetics. In chronic hypertension, progressive adaptations of these processes occur as an attempt to cope with the demanding necessity of brain functions, creating a new steady-state homeostatic ...
Source: Biochemical Pharmacology - September 30, 2022 Category: Drugs & Pharmacology Authors: Federica Ferrari Roberto Federico Villa Source Type: research

Endovascular Treatment of Acute Basilar Artery Occlusion (P4.217)
CONCLUSIONS: Data in this series showed that multimodal EVT was an effective recanalization method of acute BAO. Bridging therapy was associated with better 30-day clinical outcome. EVT should be started as soon as possible after IVT and not considered only as a rescue strategy. Study Supported by: the grants of the Internal Grant Agency of Ministry of Health of the Czech Republic number NT/11046-6/2010, NT/11386-5/2010, and NT/13498-4/2012, and by the grant project number CZ.1.05/2.1.00/01.0030.Disclosure: Dr. Herzig has received personal compensation for activities with Bayer Pharmaceuticals Corp., and Gedeon Richter. Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Herzig, R., Dornak, T., Skoloudik, D., Sanak, D., Kuliha, M., Roubec, M., Havlicek, R., Hajdukova, L., Kocher, M., Prochazka, V., Lacman, J., Charvat, F., Kral, M., Veverka, T., Zapletalova, J. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research

Defective trophoblast invasion underlies fetal growth restriction and preeclampsia-like symptoms in the stroke-prone spontaneously hypertensive rat
AbstractSTUDY QUESTIONWhat is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)?SUMMARY ANSWERSHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction (FGR).WHAT IS KNOWN ALREADYA hallmark in the pathogenesis of preeclampsia (PE) is abnormal placentation with defective remodeling o...
Source: Molecular Human Reproduction - April 27, 2017 Category: Molecular Biology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Potential Applications of Remote Limb Ischemic Conditioning for Chronic Cerebral Circulation Insufficiency
Conclusion Due to its long-term and often invisible course, CCCI has received less attention than acute cerebral ischemic stroke. However, without appropriate intervention, CCCI may lead to a variety of adverse events. Because the pathophysiological changes associated with CCCI are complex, pharmacological research in this area has been disappointing. Recent research suggests that RLIC, which is less invasive and more well-tolerated than drug treatment, can activate endogenous protective mechanisms during CCCI. In the present report, we reviewed studies related to CCCI (Table 1), as well as those related to stroke and sta...
Source: Frontiers in Neurology - May 2, 2019 Category: Neurology Source Type: research

Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease
Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. Introduction Atherosclerosis is a systemic vascular process that is considered a major cause of cerebrovascular and cardiovascular di...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment
Conclusion In this study, reduced CBF and FA and increased MD in the inner NAWM layers for both PVWMH and DWMH suggested extensive WM alterations beyond the visible WM lesions commonly observed on clinical MRI of svMCI subjects. CBF penumbras cover more extensive WM at risk than DTI penumbras, suggesting the likelihood that compromised CBF precedes white matter integrity changes, and CBF penumbras may be a potential target for the prevention of further microstructural white matter damage. The imaging parameters investigated, however, did not correlate to cognition. Author Contributions YZ, QX, and XG conceived and desig...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD)
RARITAN, N.J., May 23, 2022 – Findings from the XARELTO® (rivaroxaban) Phase 3 COMPASS Long-Term Open Label Extension (LTOLE) study and the XARELTO® in Combination with Acetylsalicylic Acid (XATOA) registry have been published in the European Society of Cardiology’s (ESC) European Heart Journal, Cardiovascular Pharmacotherapy. Additionally, the XATOA registry was presented at the American Congress of Cardiology’s 71st Annual Scientific Session (ACC.22). These studies provide further evidence supporting the role of dual pathway inhibition (DPI) with the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 100 mg...
Source: Johnson and Johnson - May 23, 2022 Category: Pharmaceuticals Source Type: news