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Total 148 results found since Jan 2013.

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

A case-control analysis of stroke in Covid-19 patients: Results of Unusual Manifestations of Covid-19-Study 11
CONCLUSIONS: The incidence of stroke in COVID-19 patients presenting to EDs was lower than in the non-COVID-19 reference sample. COVID-19 patients with stroke had greater need for hospitalization and ICU admission than those without stroke, and longer hospitalization and greater in-hospital mortality than non-COVID-19 patients with stroke.PMID:34490961 | DOI:10.1111/acem.14389
Source: Accident and Emergency Nursing - September 7, 2021 Category: Emergency Medicine Authors: Eric Jorge Garc ía-Lamberechts Òscar Miró Marcos Fragiel Pere Llorens S ònia Jiménez Pascual Pi ñera Guillermo Burillo Alfonso Mart ín Francisco Javier Mart ín-Sánchez Javier Jacob Aitor Alqu ézar-Arbé Laura Ejarque Mart ínez Bel én Rodrígue Source Type: research

Differential Characteristics of Ischemic and Hemorrhagic Stroke in Patients with Cerebral Small Vessel Disease
Conclusion: Identification of differential clinical and prognostic profile between ischemic and hemorrhagic consequences of underlying cerebral SVD is useful for risk stratification in the current process pursuing precision medicine.
Source: Neurology India - February 24, 2021 Category: Neurology Authors: Mireia Bernal Paula Escarcena Adri & #224; Arboix Lluis Garcia-Eroles Enric Verg & #233;s Laura D & #237;ez Joan Massons Source Type: research

IJERPH, Vol. 19, Pages 3182: Predictive Model and Mortality Risk Score during Admission for Ischaemic Stroke with Conservative Treatment
Conclusions: It is possible to create a predictive model of mortality for patients with ischaemic stroke from which important advances can be made towards optimising the quality and efficiency of care. The model results are available within a few minutes of admission and would provide a valuable complementary resource for the neurologist.
Source: International Journal of Environmental Research and Public Health - March 8, 2022 Category: Environmental Health Authors: Mar ía Carmen Lea-Pereira Laura Amaya-Pascasio Patricia Mart ínez-Sánchez Mar ía del Mar Rodríguez Salvador Jos é Galván-Espinosa Luis T éllez-Ramírez Fernando Reche-Lorite Mar ía-José Sánchez Juan Manuel Garc ía-Torrecillas Tags: Article Source Type: research

Associated factors with functional prognosis of patients with acute ischemic stroke undergoing thrombectomy
CONCLUSION: Age, T2D and failed recanalization increase risk for unfavorable outcome at 90 days in patients with AIS treated with MT. Procedure time duration should be considered as a possible determinant factor in functional outcome.PMID:35042605 | DOI:10.1016/j.medcli.2021.11.010
Source: Medicina Clinica - January 19, 2022 Category: General Medicine Authors: Íñigo Rodríguez-Baz Mar ía Cristo Rodríguez-Pérez Antonio Medina Rodr íguez Ignacio Hern ández Cabezudo Yolanda Sosa Cabrera Source Type: research

Inpatient rehabilitation of working-age adults with ischemic stroke: comparing men and women clinical and functional characteristics at admission and predicting functionality
CONCLUSIONS: No functional differences between men and women in any independence measure were found. Sex was a significant predictor but leaving half of the variance unexplained.PMID:35084731 | DOI:10.33588/rn.7403.2021297
Source: Revista de Neurologia - January 27, 2022 Category: Neurology Authors: A Garc ía-Rudolph S Laxe B Cegarra J Saur í-Ruiz E Opisso J M Tormos M Bernabeu Source Type: research