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Evaluation of arterial waveform derived variables for an assessment of volume resuscitation in mechanically ventilated burn patients
Conclusion: Our results suggest that measurement of stroke volume variations by arterial pulse contour analysis is valuable in monitoring volume administration and in predicting volume responsiveness during the early postburn period.
Source: Burns : Journal of the International Society for Burn Injuries - July 9, 2012 Category: Cosmetic Surgery Authors: A. Lavrentieva, Th. Kontakiotis, E. Kaimakamis, M. Bitzani Tags: Articles Source Type: research

Title: Ritual Risk: Incense Use and Cardiovascular Mortality
This study is of particular significance given that cardiovascular disease is one of the most common chronic diseases in the population worldwide,” says Karin Yeatts, an epidemiologist at the University of North Carolina at Chapel Hill, who has studied indoor air quality in the Middle East. In contrast with outdoor air pollution, incense exposure may be easier for an individual to avoid, but Yeatts says education will be needed to help people understand the risks of these exposures, similar to educational campaigns about cigarette smoking. Limitations to the study include lack of information on the type of incense burned...
Source: EHP Research - December 1, 2014 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Cardiovascular Health Combustion Emissions December 2014 Household Air Pollution Indoor Air Quality International Environmental Health Particulate Matter (PM) Volatile Organic Compounds (VOCs) Source Type: research

Life is Simple: Eat, Sleep, Swim, Repeat
A glass of crisp white and a rocket salad. And the potato mash, please. I haven't met a potato I didn't like. Famished each afternoon of my recent magical mermaid holiday, I sat down with wet salty hair, ordered and devoured. Swimming burns so much energy. I watched the beach full of swimmers and surfers. This is one wave of heaven, for me I thought, as I scribed notes on my pile of 4 X 6 cards. Noting and documenting my time in Oz waters, while watching it. I am lifted up this day. I met Mark and I get it. The magnificent pull of the sea. The perfect simple elegant solution to all that troubles us. Move in the water. Per ...
Source: Healthy Living - The Huffington Post - May 28, 2016 Category: Consumer Health News Source Type: news

ACR Appropriateness Criteria ® Cerebrovascular Disease
Publication date: May 2017 Source:Journal of the American College of Radiology, Volume 14, Issue 5, Supplement Author(s): Michael B. Salmela, Shabnam Mortazavi, Bharathi D. Jagadeesan, Daniel F. Broderick, Judah Burns, Tejaswini K. Deshmukh, H. Benjamin Harvey, Jenny Hoang, Christopher H. Hunt, Tabassum A. Kennedy, Alexander A. Khalessi, William Mack, Nandini D. Patel, Joel S. Perlmutter, Bruno Policeni, Jason W. Schroeder, Gavin Setzen, Matthew T. Whitehead, Rebecca S. Cornelius, Amanda S. Corey Diseases of the cerebral vasculature represent a heterogeneous group of ischemic and hemorrhagic etiologies, which often manife...
Source: Journal of the American College of Radiology - May 1, 2017 Category: Radiology Source Type: research

ESCAPE to Reality, Post-Trial Outcomes in an ESCAPE Centre: A Retrospective Case-Control Study.
Conclusion: ESCAPE eligible patients in our centre had favourable outcome rates superior to the published trial data. ESCAPE ineligible patients tended to do slightly less well, but still better than the favourable outcome rates achieved with IVtPA alone. There is potentially a wide discordance between the threshold for futility and trial eligibility criteria when considering endovascular treatment for acute ischaemic stroke. PMID: 29588552 [PubMed - in process]
Source: The Ulster Medical Journal - January 1, 2018 Category: General Medicine Authors: Nixon AM, Jamison M, Rennie IM, Flynn PA, Smyth G, Wiggam I, Kerr E, Fulton A, Hunter A, Burns PA Tags: Ulster Med J Source Type: research

In-hospital Outcomes of Left Ventricular Assist Devices (LVAD) Patients Undergoing Noncardiac Surgery
An increasing number of stage D heart failure patients are supported with left ventricular assist devices (LVADs), and the management of LVAD patients who require noncardiac surgery (NCS) presents unique challenges. Using the 2010–2014 National Inpatient Sample, we identified all adult cases of LVAD patients undergoing noncardiac surgeries using ICD-9-CM codes. We estimated inpatient mortality, bleeding complications, stroke, length of stay (LOS), and cost of hospitalization of the admissions related to NCS using mixed effects logistic and linear mixed regressions, respectively. A total of 30,323 patients with LVADs unde...
Source: ASAIO Journal - February 1, 2021 Category: Medical Devices Tags: Adult Circulatory Support Source Type: research

A suggested shared aetiology of dementia - a colocalization study
Neurobiol Aging. 2022 May 13;117:71-82. doi: 10.1016/j.neurobiolaging.2022.05.005. Online ahead of print.ABSTRACTIdentification of shared causal genes between dementia and its related clinical outcomes can help understand shared aetiology and multimorbidity surrounding dementia. We performed the HyPrColoc colocalization analysis to detect possible shared causal genes between dementia or Alzheimer's disease (AD) and 5 selected traits: stroke, diabetes, atherosclerosis, cholesterol level, and alcohol consumption within 601 dementia or AD associated genetic regions using summary results of the UK Biobank genome-wide associati...
Source: Neurobiology of Aging - June 8, 2022 Category: Geriatrics Authors: Xinzhu Yu Artitaya Lophatananon Krisztina Mekli Alistair Burns Kenneth R Muir Hui Guo Source Type: research

How Heat Waves Could Have Long-Term Impacts on Your Health
Health officials from the U.S., the U.K., Europe, and Japan have been warning residents to stay out of the sun as the northern hemisphere experiences some of the highest early summer temperatures ever recorded. It’s not just to prevent heat-stroke, but to prevent the long-term consequences as well. As climate change drives summer temperatures even higher than usual, medical researchers are starting to find links between sustained heat exposure and chronic health conditions ranging from diabetes to kidney stones, cardiovascular disease and even obesity. “While increased risk for heat stroke is an obvious manifes...
Source: TIME: Health - July 13, 2022 Category: Consumer Health News Authors: Aryn Baker Tags: Uncategorized climate change Climate Is Everything Evergreen healthscienceclimate Londontime overnight Source Type: news

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news

Antithrombin attenuates myocardial dysfunction and reverses systemic fluid accumulation following burn and smoke inhalation injury: a randomized, controlled, experimental study
Conclusions: Based on these findings, the supplementation of rhAT may represent a valuable therapeutic approach for cardiovascular dysfunction and inflammation after burn and smoke inhalation injury.
Source: Critical Care - May 11, 2013 Category: Intensive Care Authors: Sebastian RehbergYusuke YamamotoEva BarthaLinda SousseCollette JonkamYong ZhuLillian TraberRobert CoxDaniel TraberPerenlei Enkhbaatar Source Type: research

Regional susceptibility to stress-induced intestinal injury in the mouse.
Abstract Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders, including hemorrhagic shock, trauma, burn, pancreatitis and heat stroke. However, the susceptibility to injury of different regions of intestine in these disorders is not well understood. We compared histological injury across the small intestine in two in vivo mouse models of injury, hemorrhagic shock (30% loss of blood volume) and heat stroke (peak core temperature,42.4°C). In both, areas near the duodenum showed significantly greater mucosal injury and reductions in villi height. To determine if these eff...
Source: Am J Physiol Gastroi... - July 18, 2013 Category: Gastroenterology Authors: Novosad VL, Richards JL, Phillips NA, King MA, Clanton TL Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Methodology of a reevaluation of cardiovascular outcomes in the RECORD trial: Study design and conduct
Conclusions: Comprehensive procedures were used for rigorous event reascertainment and readjudication in a previously completed open-label, global clinical trial. These procedures used in this unique situation were consistent with other common approaches in the field, were enhanced to address the FDA concerns about the original RECORD trial results, and could be considered by clinical trialists designing event readjudication protocols for drug development programs that have been completed.
Source: American Heart Journal - June 24, 2013 Category: Cardiology Authors: Renato D. Lopes, Sheila Dickerson, Gail Hafley, Shana Burns, Sandra Tourt-Uhlig, Jennifer White, L. Kristin Newby, Michel Komajda, John McMurray, Robert Bigelow, Philip D. Home, Kenneth W. Mahaffey Tags: Trial Design Source Type: research

Results of a reevaluation of cardiovascular outcomes in the RECORD trial
Conclusions: Only a modest number of additional person-years of follow-up were ascertained from this reevaluation of CV end points in RECORD. Observed HRs and CIs from these analyses using the original RECORD or new FDA end point definitions showed similar treatment effects of rosiglitazone compared with the original RECORD results.
Source: American Heart Journal - June 6, 2013 Category: Cardiology Authors: Kenneth W. Mahaffey, Gail Hafley, Sheila Dickerson, Shana Burns, Sandra Tourt-Uhlig, Jennifer White, L. Kristin Newby, Michel Komajda, John McMurray, Robert Bigelow, Philip D. Home, Renato D. Lopes Tags: Diabetes and Metabolism Source Type: research