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Specialty: Biomedical Science
Condition: Heart Failure
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Total 170 results found since Jan 2013.
Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis
Abnormal activity of the renin-angiotensin-aldosterone system plays a causal role in the development of hypertension, atherosclerosis, and associated cardiovascular events such as myocardial infarction, stroke, and heart failure. As both a vasoconstrictor and a proinflammatory mediator, angiotensin II (Ang II) is considered a potential link between hypertension and atherosclerosis. However, a role for Ang II–induced inflammation in atherosclerosis has not been clearly established, and the molecular mechanisms and intracellular signaling pathways involved are not known. Here, we demonstrated that the RhoA GEF Arhgef1 is e...
Source: Journal of Clinical Investigation - November 14, 2017 Category: Biomedical Science Authors: Maria Luigia Carbone, Gilliane Chadeuf, Sandrine Heurtebise-Chrétien, Xavier Prieur, Thibault Quillard, Yann Goueffic, Nathalie Vaillant, Marc Rio, Laure Castan, Maxim Durand, Céline Baron-Menguy, Julien Aureille, Juliette Desfrançois, Angela Tesse, Ra Source Type: research
ADVANCIS Score Predicts Acute Kidney Injury After Percutaneous Coronary Intervention for Acute Coronary Syndrome.
In conclusion, the ADVANCIS score is a novel, simple, robust tool for predicting the risk of incident AKI after PCI for ACS, and it can aid in risk stratification to monitor patient care.
PMID: 29559842 [PubMed - in process]
Source: International Journal of Medical Sciences - March 25, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Prognostic Utility of Soluble Suppression of Tumorigenicity 2 level as a Predictor of Clinical Outcomes in Incident Hemodialysis Patients.
Conclusion: The ST2 is associated with diastolic function and may be a predictor of clinical outcomes in incident hemodialysis patients.
PMID: 29910678 [PubMed - in process]
Source: International Journal of Medical Sciences - June 20, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Editors' Choice Stroke prevention: Learning from the master (and COMMANDER)
Adding rivaroxaban to standard therapy in patients with heart failure and no atrial fibrillation did not show any beneficial effect on death risk.
Source: Science Translational Medicine - September 19, 2018 Category: Biomedical Science Authors: Santulli, G. Tags: Editors ' Choice Source Type: research
Obesity and cardiovascular disease: revisiting an old relationship
A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular diseases (CVD) including coronary heart disease, heart failure, hypertension, stroke, atrial fibrillation and sudden cardiac death. Obesity can increase CVD morbidity and mortality directly and indirectly. Direct effects are mediated by obesity-induced structural and functional adaptations of the cardiovascular system to accommodate excess body weight, as well as by adipokine effects on inflammation and vascular homeostasis.
Source: Metabolism - Clinical and Experimental - November 3, 2018 Category: Biomedical Science Authors: Chrysi Koliaki, Stavros Liatis, Alexander Kokkinos Tags: Review Source Type: research
Association of 18bp insertion/deletion polymorphism, at −2549 position of VEGF gene, with diabetic vascular complications in type 2 diabetes mellitus
ConclusionsThe multivariate logistic regression analysis showed that the D allele in the promoter region of the VEGF gene is an independent risk factor of DR irrespective of other laboratory and clinical variables in T2DM patients. Our study suggests that I/D allele in the studied gene is associated with HF and strokes.
Source: Advances in Medical Sciences - January 16, 2019 Category: Biomedical Science Source Type: research
Association of 18bp insertion/deletion polymorphism, at -2549 position of VEGF gene, with diabetic vascular complications in type 2 diabetes mellitus.
CONCLUSIONS: The multivariate logistic regression analysis showed that the D allele in the promoter region of the VEGF gene is an independent risk factor of DR irrespective of other laboratory and clinical variables in T2DM patients. Our study suggests that I/D allele in the studied gene is associated with HF and strokes.
PMID: 30654317 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - January 14, 2019 Category: Biomedical Science Authors: Gala-Błądzińska A, Czech J, Braun M, Skrzypa M, Gargasz K, Mazur A, Zawlik I Tags: Adv Med Sci Source Type: research
Prevalence and prognosis significance of cardiovascular disease in cancer patients: a population-based study.
CONCLUSIONS: Cancer patients are vulnerable to comorbidity related to heart and cerebral disease. The influence of comorbidities on prognosis is noticeable and specific both for the type of cancer and comorbidities.
PMID: 31562288 [PubMed - as supplied by publisher]
Source: Aging - September 26, 2019 Category: Biomedical Science Authors: Liu D, Ma Z, Yang J, Zhao M, Ao H, Zheng X, Wen Q, Yang Y, You J, Qiao S, Yuan J Tags: Aging (Albany NY) Source Type: research
A review of machine learning techniques in photoplethysmography for the non-invasive cuff-less measurement of blood pressure
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): C. El-Hajj, P.A. KyriacouAbstractHypertension or high blood pressure is a leading cause of death throughout the world and a critical factor for increasing the risk of serious diseases, including cardiovascular diseases such as stroke and heart failure. Blood pressure is a primary vital sign that must be monitored regularly for the early detection, prevention and treatment of cardiovascular diseases. Traditional blood pressure measurement techniques are either invasive or cuff-based, which are impractical, intermittent, and unc...
Source: Biomedical Signal Processing and Control - February 13, 2020 Category: Biomedical Science Source Type: research
Disrupted Endothelial Cell Heterogeneity and Network Organization Impair Vascular Function in Prediabetic Obesity
Obesity is a major risk factor for diabetes and cardiovascular diseases such as hypertension, heart failure, and stroke. Impaired endothelial function occurs in the earliest stages of obesity and underlies vascular alterations that give rise to cardiovascular disease. However, the mechanisms that link weight gain to endothelial dysfunction are ill-defined. Increasing evidence suggests that endothelial cells are not a population of uniform cells but are highly heterogeneous and are organized as a communicating multicellular network that controls vascular function.
Source: Metabolism - Clinical and Experimental - August 9, 2020 Category: Biomedical Science Authors: Calum Wilson, Xun Zhang, Matthew D. Lee, Margaret MacDonald, Helen R. Heathcote, Nasser M.N. Alorfi, Charlotte Buckley, Sharron Dolan, John G. McCarron Source Type: research
Thromboembolism in Patients with Hypertrophic Cardiomyopathy.
Authors: Liu L, Liu Z, Chen X, He S
Abstract
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease, which has a marked heterogeneity in clinical expression, natural history, and prognosis. HCM is associated with a high prevalence of thromboembolic events (stroke and systemic embolic events), even if taking no account of atrial fibrillation (AF), leading to unexpected disability and death in patients of all ages. Several risk factors of thromboembolism such as AF, greater age, left atrial diameter, heart failure and others have been confirmed in patients with HCM. Conventional thromboembolic predictive m...
Source: International Journal of Medical Sciences - January 14, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Comparison of long-term outcomes after trans-catheter aortic valve implantation between patients primarily diagnosed by cardiac murmur and those diagnosed by other reasons
by Yousuke Taniguchi, Kenichi Sakakura, Yohei Nomura, Masashi Hatori, Kaho Shibata, Yusuke Tamanaha, Taku Kasahara, Takunori Tsukui, Tatsuro Ibe, Kei Yamamoto, Hiroyuki Jinnouchi, Hiroshi Wada, Atsushi Yamaguchi, Hideo Fujita
Careful auscultation is the first step to diagnose aortic stenosis (AS). The aim of this study was to compare clinical outcomes following transcatheter aortic valve implantation (TAVI) between the patients primarily diagnosed by heart murmur and those diagnosed by other reasons. We retrospectively included 258 patients who underwent TAVI in our medical center, and divided those into the murmur group ...
Source: PLoS One - February 19, 2021 Category: Biomedical Science Authors: Yousuke Taniguchi Source Type: research
Acute myocardial infarction in the Covid-19 era: Incidence, clinical characteristics and in-hospital outcomes —A multicenter registry
by Alexander Fardman, Doron Zahger, Katia Orvin, Daniel Oren, Natalia Kofman, Jameel Mohsen, Or Tsafrir, Elad Asher, Ronen Rubinshtein, Jafari Jamal, Roi Efraim, Majdi Halabi, Yacov Shacham, Lior Henri Fortis, Tal Cohen, Robert Klempfner, Amit Segev, Roy Beigel, Shlomi Matetzky
BackgroundWe aimed to describe the characteristics and in-hospital outcomes of ST-segment elevation myocardial infarction (STEMI) patients during the Covid-19 era. MethodsWe conducted a prospective, multicenter study involving 13 intensive cardiac care units, to evaluate consecutive STEMI patients admitted throughout an 8-week period during the Covi...
Source: PLoS One - June 18, 2021 Category: Biomedical Science Authors: Alexander Fardman Source Type: research
Smartphone applications for physical activity and sedentary behaviour change in people with cardiovascular disease: A systematic review and meta-analysis
ConclusionsSmartphone applications were effective in increasing physical activity in people with cardiovascular disease. Caution is warranted for the low-quality evidence, small sample and larger coronary heart disease representation. More rigorous research is needed to investigate the effect of smartphone applications across diagnoses and in sedentary behaviour.
Source: PLoS One - October 11, 2021 Category: Biomedical Science Authors: Kacie Patterson Source Type: research
Diagnosis of atrial fibrillation in heart failure patients with implantable cardioverter defibrillator or cardiac resynchronisation therapy
CONCLUSIONS: Episodes of paroxysmal atrial fibrillation in patients with systolic heart failure and implanted cardioverter-defibrillator systems are quite common. The majority of the episodes recorded in the study were asymptomatic.PMID:34900037 | PMC:PMC8641502 | DOI:10.5114/aoms/114977
Source: Archives of Medical Science - December 13, 2021 Category: Biomedical Science Authors: Barbara Dominik Przemyslaw Mitkowski Wojciech Zorawski Ilona Kowalik Adam Ciesielski Source Type: research
