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A fast computational model for circulatory dynamics: effects of left ventricle-aorta coupling
Biomech Model Mechanobiol. 2023 Jan 13. doi: 10.1007/s10237-023-01690-w. Online ahead of print.ABSTRACTThe course of diseases such as hypertension, systolic heart failure and heart failure with a preserved ejection fraction is affected by interactions between the left ventricle (LV) and the vasculature. To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory system is presented. In a four-chamber model of the heart, the LV is represented by a previously described low-order, wall volume-preserving model that includes torsion and base-to-apex and circumferential wa...
Source: Biomechanics and Modeling in Mechanobiology - January 13, 2023 Category: Biomedical Science Authors: Michael J Moulton Timothy W Secomb Source Type: research

Role of cardiovascular magnetic resonance imaging and cardiopulmonary exercise test in predicting composite clinical outcomes in patients with hypertrophic cardiomyopathy
by Ji-won Hwang, Sang-Chol Lee, Darae Kim, Jihoon Kim, Eun Kyoung Kim, Sung-A. Chang, Sung-Ji Park, Sung Mok Kim, Yeon Hyeon Choe, Seung Woo Park We aimed to evaluate the additive value of cardiovascular magnetic resonance imaging (CMR) and cardiopulmonary exercise test (CPET) to predict clinical outcomes in patients with HCM. We enrolled 373 patients with HCM and normal left ventricular systolic function who underwent CPET and CMR. The pri mary outcome was a clinical composite of all-cause death, cardiac transplantation, stroke, heart failure requiring hospitalization and defibrillator implantation. During a follow-up of...
Source: PLoS One - May 16, 2023 Category: Biomedical Science Authors: Ji-won Hwang Source Type: research

Korean vs. Western Exercise Capacity Nomograms for Korean Patients With Cardiovascular Disease
CONCLUSION: Korean patients with CVD with lower exercise capacity have higher risk of MACE. Considering inter-ethnic differences in cardiorespiratory fitness, the Korean nomogram provides more suitable reference values than the Western nomogram to determine lower exercise capacity and predict cardiovascular events in Korean patients with CVD.PMID:37309698 | DOI:10.3346/jkms.2023.38.e179
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Soohyung Park Byambakhand Battumur Seo Yeon Yoon Yohan Lee Se Hyun Park Kyuho Lee Seungmin Back Jieun Lee Dong Oh Kang Jah Yeon Choi Seung-Young Roh Jin Oh Na Cheol Ung Choi Jin Won Kim Seung-Woon Rha Chang Gyu Park Eung Ju Kim Source Type: research

Post-infarct evolution of ventricular and myocardial function
Biomech Model Mechanobiol. 2023 Jul 5. doi: 10.1007/s10237-023-01734-1. Online ahead of print.ABSTRACTAdverse ventricular remodeling following acute myocardial infarction (MI) may induce ventricular dilation, fibrosis, and loss of global contractile function, possibly resulting in heart failure (HF). Understanding the relation between the time-dependent changes in material properties of the myocardium and the contractile function of the heart may further our understanding of the development of HF post-MI and guide the development of novel therapies. A finite element model of cardiac mechanics was used to model MI in a thic...
Source: Biomechanics and Modeling in Mechanobiology - July 5, 2023 Category: Biomedical Science Authors: K L P M Janssens M Kraamer L Barbarotta P H M Bovendeerd Source Type: research

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