• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Left ventricular gene expression profile of healthy and cardiovascular compromised rat models used in air pollution studies.
Authors: Ward WO, Kodavanti UP Abstract The link between pollutant exposure and cardiovascular disease (CVD) has prompted mechanistic research with animal models of CVD. We hypothesized that the cardiac gene expression patterns of healthy and genetically compromised, CVD-prone rat models, with or without metabolic impairment, will reveal underlying disease processes that facilitate understanding of the mechanisms of air pollution susceptibility differences. Left ventricular gene expression was examined using Affymetrix rat 230A-gene arrays in male, age-matched (12-14 weeks old) healthy Wistar Kyoto (WKY) and CV-com...
Source: Inhalation Toxicology - February 18, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Rat models of cardiometabolic diseases: baseline clinical chemistries, and rationale for their use in examining air pollution health effects.
Authors: Kodavanti UP, Russell JC, Costa DL Abstract Individuals with cardiovascular and metabolic diseases (CVD) are shown to be more susceptible to adverse health effects of pollutants. Rodent models of CVD are used for examining susceptibility variations. CVD models developed by selective inbreeding are shown to represent the etiology of human disease and metabolic dysfunction. The goal of this article was to review the origin and the pathobiological features of rat models of varying CVD with or without metabolic syndrome and healthy laboratory rat strains to allow better interpretation of the data regarding the...
Source: Inhalation Toxicology - February 18, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database
Obstructive sleep apnoea (OSA) is a highly prevalent condition but studies exploring the burden of OSA-associated comorbidities have been limited by small sample sizes with underrepresentation of women. We queried the Truven Health MarketScan Research Databases 2003–2012, which is a collection of health insurance claims for working adults and retirees with employer-sponsored health insurance. Adults with a diagnostic code for OSA with at least 12 months of follow-up from the index date of OSA diagnosis were compared to a matched random sample. Comorbidities were assessed using International Classification of Dis...
Source: European Respiratory Journal - March 31, 2016 Category: Respiratory Medicine Authors: Mokhlesi, B., Ham, S. A., Gozal, D. Tags: Sleep medicine Original Articles: Sleep Source Type: research

Comparisons of sleep apnoea rate and outcomes among patients with resistant and non‐resistant hypertension
ConclusionWe observed a modest increase in likelihood for SA among RH compared to non‐RH patients. Risks for IHE and CHF were higher for SA in RH compared to SA in non‐RH patients; however, there were no differences in risk for stroke and mortality.
Source: Respirology - July 17, 2016 Category: Respiratory Medicine Authors: Simran K. Bhandari, Jiaxiao Shi, Miklos Z. Molnar, Scott A. Rasgon, Stephen F. Derose, Csaba P. Kovesdy, David A. Calhoun, Kamyar Kalantar‐zadeh, Steven J. Jacobsen, John J. Sim Tags: Original Article Source Type: research

Comparisons of sleep apnoea rate and outcomes among patients with resistant and non ‐resistant hypertension
ConclusionWe observed a modest increase in likelihood for SA among RH compared to non‐RH patients. Risks for IHE and CHF were higher for SA in RH compared to SA in non‐RH patients; however, there were no differences in risk for stroke and mortality.
Source: Respirology - July 17, 2016 Category: Respiratory Medicine Authors: Simran K. Bhandari, Jiaxiao Shi, Miklos Z. Molnar, Scott A. Rasgon, Stephen F. Derose, Csaba P. Kovesdy, David A. Calhoun, Kamyar Kalantar ‐zadeh, Steven J. Jacobsen, John J. Sim Tags: Original Article Source Type: research

Long-acting bronchodilator initiation in COPD and the risk of adverse cardio-pulmonary events: A population-based comparative safety study.
CONCLUSION: COPD treatment initiation with tiotropium compared with LABA does not increase cardiovascular risk in the first year of treatment. The risk of pneumonia is higher with LABA, a likely effect of the inhaled corticosteroids present in many LABA inhalers used in real world clinical practice. PMID: 27554300 [PubMed - as supplied by publisher]
Source: Chest - August 19, 2016 Category: Respiratory Medicine Authors: Suissa S, Dellaniello S, Ernst P Tags: Chest Source Type: research

Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events: A population-based study
In conclusion, the addition of a second long-acting bronchodilator in the real world setting treatment of COPD does not increase the risk of most cardiovascular events. The modest increase for heart failure may be due to residual confounding by indication and needs further investigation.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Suissa, S., Dell'Aniello, S., Ernst, P. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Long-acting bronchodilator initiation in COPD and cardio-pulmonary risks: A population-based comparative effectiveness study
Long-acting bronchodilators, including long-acting beta2-agonists (LABA) and the anticholinergic tiotropium, are recommended as initial maintenance treatment in COPD, though their risk on cardio-pulmonary events remains uncertain in real world settings. We assessed whether treatment initiation with tiotropium increases the risk of acute myocardial infarction (AMI), stroke, heart failure, arrhythmia and pneumonia, relative to a LABA.We identified all new users of a long-acting bronchodilator during 2002-2012, age 55 or older, from the United Kingdom's Clinical Practice Research Datalink. Each patient who initiated tiotropiu...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Suissa, S., Dell'Aniello, S., Ernst, P. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

CHA2DS2 ‐VASc Scores Predict Major Adverse Cardiovascular Events in Patients with Chronic Obstructive Pulmonary Disease
Conclusion: Early lifestyle modifications and antithrombotic therapy may be essential for COPD patients at a high risk of MACEs, i.e. those with CHA2DS2‐VASc scores ≥ 6. This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - March 6, 2017 Category: Respiratory Medicine Authors: Hean Ooi, Li ‐Hsiou Chen, Yung‐Lun Ni, Huan‐Ting Shen, Yen‐Hsien Lee, Yi‐Chun Chu, Ke‐Chih Fang, I‐ Hung Chen, Shu‐Lan Hsu, Hsing‐Chun Chen, Chien‐Hsiu Huang, Kuo‐Sheng Fan, Chun‐Liang Lai, Liang‐Wen Hang Tags: Original Article Source Type: research

Obstructive sleep apnea increases the risk of cardiac events after percutaneous coronary intervention: a meta-analysis of prospective cohort studies
ConclusionsIn patients after PCI, OSA appears to increase the risk of cardiac death, non-fatal MI, and coronary revascularization.
Source: Sleep and Breathing - April 18, 2017 Category: Respiratory Medicine Source Type: research

Lifetime Risks, Projected Numbers and Adverse Outcomes in Asian Patients with Atrial Fibrillation: A Report from the Taiwan Nationwide AF Cohort Study.
CONCLUSIONS: The burden of AF amongst Asian patients is increasing, with a lifetime risk of AF being appropriately 1 in 7. Optimized management of any associated comorbidities should be part of the holistic management approach for AF. PMID: 29017957 [PubMed - as supplied by publisher]
Source: Chest - October 7, 2017 Category: Respiratory Medicine Authors: Chao TF, Liu CJ, Tuan TC, Chen TJ, Hsieh MH, Lip GYH, Chen SA Tags: Chest Source Type: research

Adding a Second Bronchodilator in COPD: A Meta-Analysis on the Risk of Specific Cardiovascular Serious Adverse Events of Tiotropium/Olodaterol Fixed-Dose Combination.
This study aimed to ascertain whether tiotropium/olodaterol (T/O) 5/5 μg fixed-dose combination (FDC) may modulate the risk of main cardiovascular outcomes in COPD patients enrolled in randomized controlled trials (RCTs). A meta-analysis (CRD42017070100) was performed by selecting RCTs reporting raw data from the ClinicalTrials.gov database concerning the impact of T/O 5/5 µg FDC vs. monocomponents on the occurrence of specific cardiovascular serious adverse events: arrhythmia, heart failure, myocardial infarction, and stroke. Data were reported as relative risk and 95% Confidence Interval, and the risk of publicatio...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 8, 2020 Category: Respiratory Medicine Tags: COPD Source Type: research

Central sleep apnea predicts pulmonary complications after cardiac surgery.
The objectives of the present study were to determine the incidence of the composite endpoint postoperative MPCs and to identify predictors for postoperative MPCs in patients without SDB, with obstructive sleep apnea (OSA) and with central sleep apnea (CSA) undergoing cardiac surgery. STUDY DESIGN: and methods: In this sub-analysis of the ongoing prospective observational study CONSIDER AF, preoperative risk factors for postoperative MPCs were examined in 250 patients undergoing cardiac surgery. Postoperative MPCs, including respiratory failure, acute respiratory distress syndrome, pneumonia, or pulmonary embolism, we...
Source: Chest - August 12, 2020 Category: Respiratory Medicine Authors: Tafelmeier M, Luft L, Zistler E, Floerchinger B, Camboni D, Creutzenberg M, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M Tags: Chest Source Type: research

Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe
Background As mortality from coronavirus disease 2019 (COVID-19) is strongly age-dependent, we aimed to identify population subgroups at an elevated risk for adverse outcomes from COVID-19 using age-/gender-adjusted data from European cohort studies with the aim to identify populations that could potentially benefit from booster vaccinations. Methods We performed a systematic literature review and meta-analysis to investigate the role of underlying medical conditions as prognostic factors for adverse outcomes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including death, hospitalisation, intensive c...
Source: European Respiratory Review - November 2, 2022 Category: Respiratory Medicine Authors: Vardavas, C. I., Mathioudakis, A. G., Nikitara, K., Stamatelopoulos, K., Georgiopoulos, G., Phalkey, R., Leonardi-Bee, J., Fernandez, E., Carnicer-Pont, D., Vestbo, J., Semenza, J. C., Deogan, C., Suk, J. E., Kramarz, P., Lamb, F., Penttinen, P. Tags: Respiratory infections and tuberculosis Reviews Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15