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Condition: Hemophilia

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Total 41 results found since Jan 2013.

Chronic Kidney Disease (CKD) in the U.S. Hemophilia Population: A Cohort Study
Conclusions: In this interim analysis of an ongoing national prospective cohort study, older men with moderate to severe hemophilia commonly report risk factors for CKD, including HTN (51.5%), DM, viral infection, and potential renal damaging medication use. Only 11.6% had CVD. Urological symptoms were also common, including hematuria and obstructive symptoms with urination.In our cohort, 11.4% met the definition of CKD, defined as the presence of either kidney damage or GFR < 60 ml/min/1.73 m2 for ≥ 3 months. The distribution of GFR values appeared similar to the general population. As with risk factors associated w...
Source: Blood - November 21, 2018 Category: Hematology Authors: Sood, S. L., Cheng, D., Shapiro, A., Kessler, C. M., Key, N. S., Quon, D., Eyster, M. E., Manco-Johnson, M. J., Kempton, C. L., Cuker, A., Ragni, M. V., Kuriakose, P., von Drygalski, A., Kouides, P. A., Escobar, M. A., Wheeler, A. P., Wang, T.-F., Leissin Tags: 322. Disorders of Coagulation or Fibrinolysis: Poster II Source Type: research

Prevalence of the age-related diseases in older patients with acquired thrombotic thrombocytopenic purpura.
CONCLUSIONS: Our findings suggest that a careful comprehensive geriatric assessment of acquired TTP patients is necessary. It is important to look for other autoimmune diseases and such age-related comorbidities as osteoporosis, arterial hypertension, ischemic heart disease and cerebrovascular disease. PMID: 32201091 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - March 18, 2020 Category: Internal Medicine Authors: Agosti P, Mancini I, Gianniello F, Bucciarelli P, Artoni A, Ferrari B, Pontiggia S, Trisolini SM, Facchini L, Carbone C, Peyvandi F, Italian Group of TTP Investigators Tags: Eur J Intern Med Source Type: research

Left atrial appendage closure: a balanced management of the thromboembolic risk in patients with hemophilia and atrial fibrillation
AbstractAtrial fibrillation is the most common cardiac arrhythmia and is a major cause of embolic stroke. In patients at high bleeding risk such as those with hemophilia, the thromboembolic prevention is challenging. We herein present three patients affected by moderate to severe hemophilia and atrial fibrillation that were treated in our Institution between March 2018 and September 2019, with percutaneous left atrial appendage closure. In patients with relative or absolute contraindications to long-term anticoagulant therapy, the left atrial appendage closure could represent a reasonable strategy.
Source: Journal of Thrombosis and Thrombolysis - April 7, 2020 Category: Hematology Source Type: research

Left atrial appendage occlusion for management of atrial fibrillation in persons with hemophilia
Due to advancements in hemophilia care, the overall life expectancy of persons with hemophilia is almost approaching that of the general population [1]. As a result, a growing population of elderly hemophilia patients is now prone to the same age-related cardiovascular comorbidities, such as coronary artery disease (CAD) and atrial fibrillation (AF) [2,3]. The management of AF is a challenge as antithrombotic therapy, the standard of care, is usually contraindicated in persons with hemophilia. Left atrial appendage occlusion (LAAO) is an alternative option for stroke prevention in patients with AF with a contraindication t...
Source: Thrombosis Research - August 4, 2021 Category: Hematology Authors: Ming Y. Lim, Mouhamed Yazan Abou-Ismail Tags: Letter to the Editors-in-Chief Source Type: research

Left atrial appendage occlusion in haemophilia patients with atrial fibrillation
ConclusionsLAAO is feasible in haemophilia patients with concurrent atrial fibrillation. However, special care including intravenous substitution with coagulation factors must be given in the periprocedural management.
Source: Journal of Interventional Cardiac Electrophysiology - November 25, 2021 Category: Cardiology Source Type: research

Cardiovascular disease in hereditary haemophilia: The challenges of longevity
Br J Haematol. 2022 Feb 21. doi: 10.1111/bjh.18085. Online ahead of print.ABSTRACTThe development of effective and safe treatments has significantly increased the life expectancy of persons with haemophilia (PWH). This has been accompanied by an increase in the comorbidities of ageing including cardiovascular disease, which poses particular challenges due to the opposing risks of bleeding from haemophilia and antithrombotic treatments versus thrombosis. Although mortality secondary to coronary artery disease in PWH is less than in the general population, the rate of atherosclerosis appears similar. The prevalence of atrial...
Source: Atherosclerosis - February 22, 2022 Category: Cardiology Authors: Susan Shapiro Gary Benson Gillian Evans Catherine Harrison Sarah Mangles Mike Makris Source Type: research

Severe Hemophilia A and Moyamoya Syndrome in a 19-Year-Old Boy Caused by Xq28 Microdeletion
In conclusion, diagnosis of MMD should be considered in any male, young patient with symptoms of ischemic stroke with no obvious explanation, and especially in patients with known hemophilia, since a relationship between the two conditions has been documented.Case Rep Neurol 2022;14:261 –267
Source: Case Reports in Neurology - May 30, 2022 Category: Neurology Source Type: research

Above the threshold time of coagulation: delayed diagnosis of acquired hemophilia A
A man in his 80 ’s presented to our hospital's emergency department with left hip pain after falling while transferring from a wheelchair on a visit day. He had been taking clopidogrel for> 10 years after atherothrombotic stroke and apixaban 2.5 mg b.i.d. for 2 years since he was diagnosed with deep vein thrombosis. The patient had no coagulation abnormalities when he started apixaban therapy and had never experienced bleeding events. His medical history included cervical spondylosis surgery, right femoral neck fracture, hypertension, and benign prostatic hypertrophy.
Source: The American Journal of Medicine - February 23, 2023 Category: General Medicine Authors: Mayu Kikuchi, Yukinori Harada, Ayano Hamai, Sachi Takaoka Tags: Diagnostic dilemma Source Type: research

Internal carotid artery dissection in a patient with hemophilia A: a case report and literature review
We report the case of a man with hemophilia A who developed sCeAD and transient oculo-pyramidal syndrome and was treated with acetylsalicylic acid. We also review previous published cases of arterial dissection in patients with hemophilia, discussing the potential pathogenetic mechanism underlying this rare association and potential antithrombotic therapeutic options.
Source: Neurological Sciences - April 15, 2023 Category: Neurology Source Type: research