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HRT optimization, using transdermal estradiol plus micronized progesterone, a safer HRT.
Abstract ABSTRACT Hormone replacement therapy (HRT) remains the gold standard for treatment of climacteric symptoms in menopausal women; it is relatively safe in healthy subjects for at least 5 years, provided it had been initiated before the age of 60 years and/or within 10 years from menopause. Estrogen probably adds some cardioprotection, that can, however, be obscured by progestogens, especially medroxyprogesterone acetate (MPA). Oral HRT is associated with an increased risk of venous thromboembolism (VTE), gallbladder disease and possibly stroke. The increased occurrence of all these events can be prevented b...
Source: Climacteric - July 19, 2013 Category: Geriatrics Authors: L'hermite M Tags: Climacteric Source Type: research

UK 'among worst' for cancer linked to obesity
Conclusion This international study has shown alarming increases in cases of cancer that can be attributed to high BMI. Overall, they estimated that 3.6% of cancers in adults (aged over 30 years) worldwide are caused by high BMI, with the proportion attributed to obesity slightly higher in women than in men. In the UK, 4.4% of all cases of cancer per year in men and 8.2% of all cases of cancer per year in women, were estimated to be attributable to obesity. The research focused on cancers that the WCRF has already established are linked to high BMI. When looking at these cancers, the UK was joint second highest in the worl...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Cancer Obesity Source Type: news

Presence of gallstones and the risk of cardiovascular diseases: The EPIC-Germany cohort study
Conclusions Our results indicate an increased cardiovascular risk for gallstone formers, which cannot be counteracted by gallbladder removal and opens up perspectives for individualized prevention strategies.
Source: European Journal of Preventive Cardiology - February 10, 2015 Category: Cardiology Authors: Wirth, J., Giuseppe, R. d., Wientzek, A., Katzke, V. A., Kloss, M., Kaaks, R., Boeing, H., Weikert, C. Tags: Original scientific papers Source Type: research

September Is Childhood Obesity Month -- Get The Facts
The obesity epidemic continues to dominate headlines--and for good reason. Obesity is a leading cause of heart disease, diabetes, high blood pressure, and stroke. Many of these conditions occur in adults but often begin in childhood. This September is National Childhood Obesity Awareness Month. By knowing the facts and taking steps to help your children live a healthier lifestyle, childhood obesity and its resulting complications may be prevented. The Facts According to the Centers for Disease Control & Prevention (CDC), one in three children in the U.S. is overweight or obese. Childhood obesity doubled in children and ...
Source: Healthy Living - The Huffington Post - September 28, 2016 Category: Consumer Health News Source Type: news

Adiponectin: a relevant player in obesity-related colorectal cancer?
Obesity is a condition characterised by an abnormally elevated mass of body fat. The past decades have seen a dramatic rise in the worldwide incidence of obesity due to lifestyle changes that have led to an overall reduced physical activity and an increase in the intake of excessive and/or highly caloric or processed foods. As a consequence, obesity represents nowadays a major global health concern. In particular, several epidemiological studies have linked obesity to a shortened lifespan due primarily to a higher risk for the development of chronic pathologies that include cardiovascular complications such as high blood p...
Source: Gut - February 28, 2013 Category: Gastroenterology Authors: Cava, A. L. Tags: Commentary Source Type: research

Overweight and obesity on the island of Ireland: an estimation of costs
Conclusions The costs are substantial, and urgent public health action is required in Ireland to address the problem of increasing prevalence of overweight and obesity, which if left unchecked will lead to unsustainable cost escalation within the health service and unacceptable societal costs.
Source: BMJ Open - March 16, 2015 Category: Journals (General) Authors: Dee, A., Callinan, A., Doherty, E., O'Neill, C., McVeigh, T., Sweeney, M. R., Staines, A., Kearns, K., Fitzgerald, S., Sharp, L., Kee, F., Hughes, J., Balanda, K., Perry, I. J. Tags: Open access, Epidemiology, Health economics Research Source Type: research

Catching Dick: Not Why We Care About Weight
Amy Schumer said in her humorous acceptance speech at the Glamour Women of the Year Awards: "I'm like 160 pounds right now, and I can catch a dick whenever I want, and that's the truth." The line, like many in her speech, is obviously very funny. But the humor is directed at a misperception that is not so funny. With our society's superficial focus on youth and appearance, we have emphasized all the wrong reasons for maintaining a healthy body weight, which has nothing to do with "catching dick." We are sold the idea that remaining slim is primarily important as a means of attracting the opposite sex, rather than as a pa...
Source: Science - The Huffington Post - June 4, 2015 Category: Science Source Type: news

Pediatric obesity: Causes, symptoms, prevention and treatment.
Authors: Xu S, Xue Y Abstract Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults. Obe...
Source: Experimental and Therapeutic Medicine - February 4, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

From Leptin, DEXA, and Beyond
Kahn and Bullard “recommend that waist circumference be added to BMI [body mass index] as a primary tool for assessing adiposity.”1 Suggesting “a need for alternative approaches to anthropometry”1 is necessary because BMI incorrectly classifies obesity by 39%.2 Many adults are obese by American Society of Ba riatric Physicians criteria of body fat: ≥25% for men and ≥30% for women.3 Normal-weight obese adults have increased mortality risk from diabetes, hypertension, heart disease, stroke, cancer, dyslipidemia, liver and gallbladder disease, sleep apnea and respiratory problems, and osteoarthritis.
Source: The American Journal of Medicine - July 22, 2016 Category: Journals (General) Authors: Eric R. Braverman Tags: AJM online Source Type: research

Variation of all-cause and cause-specific mortality with body mass index in one million Swedish parent-son pairs: An instrumental variable analysis
ConclusionsConsistent with previous large-scale meta-analyses and reviews, results supported the causal role of higher BMI in increasing the risk of several common causes of death, including cancers with increasing global incidence. We also found positive effects of BMI on mortality from respiratory disease, prostate cancer, and lung cancer, which has been inconsistently reported in the literature, suggesting that the causal role of higher BMI in mortality from these diseases may be underestimated. Furthermore, we expect different patterns of bias in the current observational and IV analyses; therefore, the similarities be...
Source: PLoS Medicine - August 8, 2019 Category: Internal Medicine Authors: Kaitlin H. Wade Source Type: research

Physical health risks of middle-aged people with low social independence: fatal diseases in men, and little attendance to cancer screenings in both sexes
CONCLUSIONS: In terms of current physical health, low-social-independent men have more fatal diseases. Both sexes with low social independence seldom attend cancer screenings and have an increased risk of developing progressive cancer in the future. At least in terms of non-smoking and non-drinking, they live healthier lives than the control group, and what makes low-social-independent men have various fatal diseases is still unclear.PMID:36846461 | PMC:PMC9948749 | DOI:10.7717/peerj.14904
Source: Cancer Control - February 27, 2023 Category: Cancer & Oncology Authors: Haruaki Naito Katsuya Nitta Misooja Lee Takeshi Ushigusa Motoki Osawa Takahiro Tabuchi Yasuhiro Kakiuchi Source Type: research