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Total 74 results found since Jan 2013.

Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice
AbstractDuring recovery, stroke patients are at risk of developing long-term complications that impact quality of life, including changes in body weight and composition, depression and anxiety, as well as an increased risk of subsequent vascular events. The aetiologies and time-course of these post-stroke complications have not been extensively studied and are poorly understood. Therefore, we assessed long-term changes in body composition, metabolic markers and behaviour after middle cerebral artery occlusion in mice. These outcomes were also studied in the context of obesity, a common stroke co-morbidity proposed to prote...
Source: Translational Stroke Research - December 20, 2019 Category: Neurology Source Type: research

Cerebellar Fastigial Nucleus Electrical Stimulation Alleviates Depressive-Like Behaviors in Post-Stroke Depression Rat Model and Potential Mechanisms
Conclusion: FNS treatment alleviates depressive-like behaviors and rCBF in PSD rats model, which could be attributed to its ability to protect cerebellar Purkinje cells and decrease the mRNA level of inflammatory cytokines.Cell Physiol Biochem 2017;41:1403 –1412
Source: Cellular Physiology and Biochemistry - March 17, 2017 Category: Cytology Source Type: research

Diabetes Lifestyle Intervention Does Not Reduce Heart Attack Or Stroke Risk
A long-term, intensive lifestyle intervention program for type 2 diabetes patients that focused on weight loss and exercise did not reduce the risk of stroke or heart attacks, researchers involved in the "Look AHEAD" trial explained at the American Diabetes Association's 73rd Scientific Sessions, Chicago, Illinois. However, the program improved patients' physical quality of life, reduced incidence and severity of depressive symptoms, lowered medical costs because of fewer hospitalizations, outpatient care and medications, and also reduced *microvascular complications...
Source: Health News from Medical News Today - June 25, 2013 Category: Consumer Health News Tags: Diabetes Source Type: news

Fat Shaming Can Literally Break Your Heart
This reporting is brought to you by HuffPost’s health and science platform, The Scope. Like us on Facebook and Twitter and tell us your story: scopestories@huffingtonpost.com.   Sarah DiGiulio is The Huffington Post’s sleep reporter. You can contact her at sarah.digiulio@huffingtonpost.com.  -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - February 4, 2017 Category: Consumer Health News Source Type: news

O27  Frailty and co-morbidity in people with osteoarthritis and rheumatoid arthritis
Conclusion Co-morbidity is associated with an increased occurrence of pre-frailty and frailty among people with OA and RA and interacts synergistically with OA and RA to increase the likelihood of pre-frailty and frailty.Disclosure M.J. Cook: None.M. Lunt: None.S.M.M. Verstappen: None.T.W. O'Neill: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Frailty, dependency and mortality predictors in a cohort of Cuban older adults, 2003-2011.
CONCLUSIONS: Given the challenge for developing countries presented by demographic and epidemiologic transition; the high prevalence in older adults of frailty syndrome, dependency and chronic non-communicable diseases; and the association of all these with higher mortality, attention should be targeted to older adults as a risk group. This should include greater social protection, age-appropriate health services, and modification and control of cardiovascular risk factors. PMID: 24487672 [PubMed - indexed for MEDLINE]
Source: MEDICC Review - November 21, 2015 Category: Global & Universal Tags: MEDICC Rev Source Type: research

Optimal Blood Pressure for Cognitive Function: Findings from an Elderly African‐American Cohort Study
ConclusionHigh and low BP were associated with poorer cognitive performance. A joint optimal region of SBP and DBP for cognitive function has been identified, which may provide useful clinical information on optimal BP control in cognitive health and lead to better quality of life for elderly adults.
Source: Journal of the American Geriatrics Society - May 6, 2013 Category: Geriatrics Authors: Hai Liu, Sujuan Gao, Kathleen S. Hall, Frederick W. Unverzagt, Kathleen A. Lane, Christopher M. Callahan, Hugh C. Hendrie Tags: Clinical Investigations Source Type: research

A case report of adult lead toxicity following use of Ayurvedic herbal medication
DiscussionA high index of suspicion of metal toxicity is necessary among persons with characteristic symptoms and signs in the absence of occupational exposure. Despite limited evidence for chelation in adults and in those with modest blood lead levels, this patient appeared to benefit from repeated chelation therapy. Both allopathic and alternative medicine practitioners and public health specialists need to be aware of the potential for contamination of and side effects from alternative pharmacologic and herbal therapies.
Source: Journal of Occupational Medicine and Toxicology - October 2, 2013 Category: Occupational Health Authors: Laura BreeherFred GerrLaurence Fuortes Source Type: research

Kidney Function and Prevalent and Incident Frailty.
CONCLUSIONS: In community-dwelling elders, lower eGFRcys was associated with a higher risk of prevalent and incident frailty whereas lower eGFRSCr was not. These findings highlight the importance of considering non-GFR determinants of kidney function. PMID: 24178972 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 31, 2013 Category: Urology & Nephrology Authors: Dalrymple LS, Katz R, Rifkin DE, Siscovick D, Newman AB, Fried LF, Sarnak MJ, Odden MC, Shlipak MG Tags: Clin J Am Soc Nephrol Source Type: research

No pain, no gain? Getting the most out of exercise
Staying in shape has all sorts of benefits, from maintaining heart health to warding off dementia and cancerInactivity – fuelled by cars and a sedentary work life – has been dubbed the biggest public health problem of the 21st century, a global pandemic with dramatic impact on peoples wellbeing. The latest reports suggest that around the world it was responsible for 5.3 million deaths in 2008 – around one in 10 – more deaths than smoking.Not only does exercise make you fitter, it can also ward off numerous and often unexpected diseases, from heart attacks, to diabetes, some forms of cancer and dementia. There are t...
Source: Guardian Unlimited Science - January 13, 2014 Category: Science Authors: Catherine de Lange Tags: Cycling Fitness Sport Running Transport Yoga Weightlifting Features UK news Life and style Cycle hire schemes The Observer Swimming Science Source Type: news

A safe, effective diet pill - the elusive holy grail
Trade in illegal, ineffective drugs flourishes as pharmaceutical industry repeatedly fails to produce successful pillAttempts to invent a safe and effective diet pill have foundered time and again, allowing the internet trade in illegal and ineffective herbal supplements and dangerous drugs, such as DNP, to flourish.A successful diet pill could make billions for the pharmaceutical industry, but efforts to date have ended in disaster, with patients harmed, drugs banned and massive compensation paid out.Fen-phen, an appetite suppressant, was the most spectacular failure. It was withdrawn in the US in 1997 after causing wides...
Source: Guardian Unlimited Science - January 14, 2014 Category: Science Authors: Sarah Boseley Tags: The Guardian Diets and dieting Drugs trade Healthcare industry World news Pharmaceuticals industry & wellbeing Health policy Society Politics UK news Life and style Public services policy Business Science Source Type: news

Cardiovascular effects of current and future anti-obesity drugs.
Abstract The prevalence of obesity increases and is associated with increases in co-morbidities e.g. type 2 diabetes, hyperlipidemia, hypertension, obstructive sleep apnea, heart disease, stroke, asthma, several forms of cancer, depression, and may result in reduction of expected remaining lifespan. We have reviewed the adverse effects on the cardiovascular system of anti-obesity drugs now retracted from the market as well as the cardiovascular profile of current drugs and potential pathways which are considered for treatment of obesity. Fenfluramine, and sibutramine were withdrawn due to increased cardiovascular ...
Source: Current Vascular Pharmacology - May 24, 2014 Category: Drugs & Pharmacology Authors: Comerma-Steffensen S, Grann M, Andersen CU, Rungby J, Simonsen U Tags: Curr Vasc Pharmacol Source Type: research

Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial
DiscussionIf Se treatment reduces the progression of Chagas cardiopathy, the inclusion of this micronutrient in the daily diet can improve the therapeutic regimen for this neglected tropical disease at low cost.Trial registration: Clinical Trials.gov ID: NCT00875173 (registered 20 October 20 2008).
Source: Trials - October 6, 2014 Category: Journals (General) Authors: Pedro Alvarenga Americano do BrasilAndréa Pereira de SouzaAlejandro Hasslocher-MorenoSérgio XavierSonia Lambert PassosMaria de Fátima Ramos MoreiraMarília Santini de OliveiraGilberto Sperandio da SilvaRoberto Magalhães SaraivaClaudia Santos de Aguiar Source Type: research

NIH state-of-the-science conference statement on prevention of fecal and urinary incontinence in adults.
CONCLUSIONS: (1) Fecal incontinence and urinary incontinence will affect more than one fourth of all U.S. adults during their lives. The natural history of fecal incontinence is unknown, and the natural history of urinary incontinence over several years is not well described. (2) Fecal incontinence and urinary incontinence often have serious effects on the lives of the many individuals who suffer physical discomfort, embarrassment, stigma, and social isolation, and on family members, caregivers, and society. Financial costs are substantial and may be underestimated because of underreporting. (3) Routine episiotomy is the m...
Source: NIH Consensus and State of the Science Statements - November 16, 2014 Category: American Health Tags: NIH Consens State Sci Statements Source Type: research