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Nutrition: Zinc

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Total 98 results found since Jan 2013.

Identifying potential therapeutic targets for ischemic stroke through immune infiltration analysis and construction of a programmed cell death ‑related ceRNA network
Exp Ther Med. 2022 Sep 21;24(5):680. doi: 10.3892/etm.2022.11616. eCollection 2022 Nov.ABSTRACTThe present study aimed to uncover the underlying mechanisms and potential intervention targets of ischemic stroke (IS). An immune cell infiltration analysis using CIBERSORT was performed on two stroke-related datasets from the Gene Expression Omnibus database to generate a competitive endogenous RNA (ceRNA) network. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to predict potential biological functions of the network. Differentially expressed genes in the ceRNA net...
Source: Experimental and Therapeutic Medicine - October 3, 2022 Category: General Medicine Authors: Yiteng Cui Xin Zhou Pingping Meng Shanshan Dong Ziwei Wang Tongye Liu Xiaomin Liu Yunteng Cui Yuyang Wang Qiang Wang Source Type: research

Associations of multiple plasma metals with the risk of ischemic stroke: A case-control study.
CONCLUSIONS: Our study suggested that higher plasma concentrations of aluminum, arsenic, and cadmium, and lower concentrations of iron and selenium may increase the risk of IS. Further prospective studies in larger populations are warranted to confirm our findings. PMID: 30716572 [PubMed - as supplied by publisher]
Source: Environment International - February 1, 2019 Category: Environmental Health Authors: Wen Y, Huang S, Zhang Y, Zhang H, Zhou L, Li D, Xie C, Lv Z, Guo Y, Ke Y, Wu T, Cheng J Tags: Environ Int Source Type: research

MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.
In conclusion, our data reveal a novel role of miR-191 in promoting ischemic brain injury through inhibiting angiogenesis via targeting VEZF1. Therefore, miR-191 may serve as a biomarker or a therapeutic target for AIS. PMID: 31064890 [PubMed - as supplied by publisher]
Source: Aging - May 6, 2019 Category: Biomedical Science Authors: Du K, Zhao C, Wang L, Wang Y, Zhang KZ, Shen XY, Sun HX, Gao W, Lu X Tags: Aging (Albany NY) Source Type: research

Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1 α/VEGF signaling pathway in experimental stroke
CONCLUSIONS: Zinc significantly improves neurological function recovery during the cerebral ischemia repair stage, providing new evidence supporting zinc as a potential therapeutic target for ischemic stroke by promoting astrocyte induced angiogenesis.PMID:35855611 | DOI:10.1111/cns.13918
Source: CNS Neuroscience and Therapeutics - July 20, 2022 Category: Neuroscience Authors: Yang Li Tingting Ma Xiaoyu Zhu Mingqi Zhang Liang Zhao Peng Wang Jia Liang Source Type: research

Neuroprotective activity of leukemia inhibitory factor is relayed through myeloid zinc finger-1 in a rat model of stroke
AbstractThe aim of this study was to determine whether leukemia inhibitory factor (LIF) exerts its neuroprotective effects through signal transduction of the transcription factor myeloid zinc finger-1 (MZF-1). According to the hypothesis of this study, MZF-1 mediates LIF-induced neuroprotective signaling during ELVO through increased expression and transcriptional activity. To determine the in vivo role of MZF-1 in LIF-induced neuroprotection, we used Genomatix software was used to MZF-1 sites in the promoter region of the rat superoxide dismutase 3 (SOD3) gene. Stroke was induced via middle cerebral artery occlusion, and ...
Source: Metabolic Brain Disease - January 5, 2019 Category: Neurology Source Type: research

Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction
Eur J Med Chem. 2021 Mar 17;218:113383. doi: 10.1016/j.ejmech.2021.113383. Online ahead of print.ABSTRACTHistone deacetylase 6 (HDAC6) has become a promising therapeutic target for central nervous system diseases due to its more complex protein structure and biological functions. However, low brain penetration of reported HDAC6 inhibitors limits its clinical application in neurological disorders. Therefore, the benzazepine, a brain-penetrant rigid fragment, was utilized to design a series of selective HDAC6 inhibitors to improve brain bioavailability. Various synthetic strategies were applied to assemble the tetrahydro-ben...
Source: European Journal of Medicinal Chemistry - April 2, 2021 Category: Chemistry Authors: Zheng Guo Zixue Zhang Yi Zhang Guan Wang Ziyi Huang Qinwei Zhang Jianqi Li Source Type: research

Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A
CONCLUSION: Altogether, our study showed that high expression of circPDS5B exacerbated IS through recruitment of hnRNP to stabilize Runx1/ZNF24 and subsequently inactivate VEGF-A. Our findings suggest circPDS5B may be a novel therapeutic target for IS.PMID:36925052 | DOI:10.1016/j.nbd.2023.106080
Source: Neurobiology of Disease - March 16, 2023 Category: Neurology Authors: Zhongzhong Jiang Yugang Jiang Source Type: research

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research