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Folic Acid May Help Ward Off Stroke in People With High Blood Pressure
Title: Folic Acid May Help Ward Off Stroke in People With High Blood PressureCategory: Health NewsCreated: 3/15/2015 12:00:00 AMLast Editorial Review: 3/16/2015 12:00:00 AM
Source: MedicineNet High Blood Pressure General - March 16, 2015 Category: Cardiology Source Type: news

Hypertension: Folic acid reduces stroke risk
Nature Reviews Cardiology 12, 257 (2015). doi:10.1038/nrcardio.2015.45 Author: João H. Duarte Several randomized trials have shown no beneficial effect of folic acid in preventing cardiovascular disease, but some reports have suggested that folic acid supplementation might decrease the incidence of stroke. In a new study published in the Journal of the American Medical Association, the
Source: Nature Reviews Cardiology - March 31, 2015 Category: Cardiology Authors: João H. Duarte Tags: Research Highlight Source Type: research

Efficacy of folic acid in primary prevention of stroke among patients with hypertension in China
After folic acid had been documented to reduce birth defects, the United States mandated folic acid food fortification in grain products in 1996 and implemented the policy by 1998.1 Around this time, controversy surfaced on adverse effects of folic acid, namely its possible role in promoting carcinogenesis. However, data over the next decade failed to provide sufficient evidence to support such a claim.1,2 In addition to decreasing neural tube defects, folic acid supplementation has been hypothesized to decrease the risk of stroke and cardiovascular events; however, among the multiple randomized controlled studies thus far...
Source: Journal of the American Society of Hypertension - August 18, 2015 Category: Cardiology Authors: Sangita Goel, Franz H. Messerli Tags: Commentary Source Type: research

ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants
Publication date: Available online 22 November 2019Source: Journal of Cardiology CasesAuthor(s): Elena Vladimirovna Reznik, Ekaterina Sergeevna Shcherbakova, Svetlana Vasilievna Borisovskaya, Yurij Valerevich Gavrilov, Tatyana Mikhailovna Pajeva, Sergey Vladislavovich Lepkov, Aleksej Borisovich Mironkov, Eliso Murmanovna Dzhobava, Igor Gennadievich NikitinAbstractThis clinical case report describes the simultaneous development of an acute myocardial infarction, stroke, and a massive pulmonary thromboembolism in a 44-year-old patient — a carrier of the thrombophilia gene polymorphisms: MTHFR C677T, А1298C, PAI-1 4G/5G, I...
Source: Journal of Cardiology Cases - November 23, 2019 Category: Cardiology Source Type: research

A Study of Srum Homocysteine Level in Ischaemic Stoke
CONCLUSION: The present study revealed that hyperhomocysteinemia appears to be an important risk factor for ischemic stroke. It is therefore important to use serum homocysteine as an important tool to investigate all cases of ischemic stroke and if serum homocysteine is elevated patient should be put on multivitamins containing vitamin B12, folic acid and pyridoxine to reduce serum homocysteine levels.PMID:35443421
Source: Atherosclerosis - April 21, 2022 Category: Cardiology Authors: Kaushik Paul Ramakrishna Mr Source Type: research

The current status of homocysteine as a risk factor for cardiovascular disease: a mini review.
Authors: Chrysant SG, Chrysant GS Abstract INTRODUCTION: Hyperhomocysteinemia has been considered as a risk factor for systemic atherosclerosis, cardiovascular disease (CVD) and stroke and many epidemiologic and case-controlled studies have demonstrated its association with these complications. In addition, treatment of hyperhomocysteinemia with folic acid ± B vitamins prevents the development of atherosclerosis, CVD and strokes. However, subsequent prospective, randomized, placebo- controlled trials have not shown an association of high homocysteine levels or their lowering with treatment with the incidence of at...
Source: Expert Review of Cardiovascular Therapy - July 8, 2018 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials Epidemiology
Conclusions Our meta-analysis indicated a 10% lower risk of stroke and a 4% lower risk of overall CVD with folic acid supplementation. A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels. Folic acid supplementation had no significant effect on risk of coronary heart disease.
Source: JAHA:Journal of the American Heart Association - August 14, 2016 Category: Cardiology Authors: Li, Y., Huang, T., Zheng, Y., Muka, T., Troup, J., Hu, F. B. Tags: Cardiovascular Disease, Diet and Nutrition Epidemiology Source Type: research

Folic acid therapy reduces the risk of mortality associated with heavy proteinuria among hypertensive patients
Objective: We aimed to evaluate whether proteinuria and estimated glomerular filtration rate (eGFR) levels can modify the efficacy of folic acid therapy on the risk of all-cause mortality among hypertensive patients in the China Stroke Primary Prevention Trial, a randomized, double-blind, and controlled trial. Methods: A total of 20 702 hypertensive patients without a history of major cardiovascular diseases were randomly assigned to a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0.8-mg folic acid (n = 10 348), or 10-mg enalapril alone (n = 10 354). All-cause mortality, a pr...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research

Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
The objective of this study is to explore the current literature supporting the use oral multivitamins and multi/minerals (OMVMs) for cardiovascular diseases (CVD) treatment and prevention.Recent FindingsData on multivitamins, vitamin C and D, coenzyme Q, calcium, and selenium, has showed no consistent benefit for the prevention of CVD, myocardial infarction, or stroke, nor was there a benefit for all-cause mortality to support their routine supplementation. Folic acid alone and B vitamins with folic acid, B6 and B12, reduce stroke, whereas niacin and antioxidants are associated with an increased risk of all-cause mortalit...
Source: Current Cardiology Reports - February 13, 2020 Category: Cardiology Source Type: research

Editorial: Efficacy of Folic Acid in Primary Prevention of Stroke Among Patients With Hypertension in China
After folic acid had been documented to reduce birth defects, the United States mandated folic acid food fortification in grain products in 1996 and implemented the policy by 1998. 1 Around this time, controversy surfaced on adverse effects of folic acid, namely its possible role in promoting carcinogenesis. However, data over the next decade failed to provide sufficient evidence to support such a claim.1 Of note, folic acid, in some instances can mask anemia from B12 deficiency and may interact with the therapeutic levels of certain medications.
Source: Journal of the American Society of Hypertension - August 18, 2015 Category: Cardiology Authors: Sangita Goel, Franz H. Messerli Source Type: research

Effects of Folic Acid Therapy on the New-Onset Proteinuria in Chinese Hypertensive PatientsNovelty and Significance Clinical Trials
In conclusion, enalapril–folic acid therapy, compared with enalapril alone, significantly reduced the development of proteinuria in diabetic patients with hypertension.Clinical Trial Registration—URL: http://www.ClinicalTrials.gov. Unique identifier: NCT00794885.
Source: Hypertension - July 12, 2017 Category: Cardiology Authors: Youbao Li, Min Liang, Guobao Wang, Binyan Wang, Mingli He, Genfu Tang, Delu Yin, Xin Xu, Yong Huo, Yimin Cui, Fan Fan Hou, Xianhui Qin Tags: Clinical Studies, Diabetes, Type 1, Diet and Nutrition, Hypertension Original Articles Source Type: research

The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT
ConclusionIn a subgroup of Chinese hypertensive patients who had received 5 ‐year antihypertensive therapy, increases in folate status were associated with higher reductions in PWV, and individuals with the CC genotype showed greatest PWV response to folic acid supplementation.
Source: Cardiovascular Therapeutics - November 20, 2018 Category: Cardiology Authors: Xin Yang, Minghua Zhang, Rensheng Song, Changfu Liu, Yong Huo, Geng Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

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