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Nutrition: Vitamin B9
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Total 163 results found since Jan 2013.
A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
Abstract
Stroke is a leading cause of disability and death world-wide and nutrition is a modifiable risk factor for stroke. Metheylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of folic acid, a B-vitamin. In humans, a polymorphism in MTHFR (677C→T) is linked to increased risk of stroke, but the mechanisms remain unknown. The Mthfr+/- mice mimic a phenotype described in humans at bp677. Using this mouse model, the aim of this study was to investigate the impact of MTHFR deficiency on stroke outcome. Male Mthfr+/- and wildtype littermate control mice were aged (~1.5-year-old) and tr...
Source: Experimental Neurology - July 25, 2018 Category: Neurology Authors: Jadavji NM, Emmerson JT, Shanmugalingam U, MacFarlane AJ, Willmore WG, Smith PD Tags: Exp Neurol Source Type: research
The current status of homocysteine as a risk factor for cardiovascular disease: a mini review.
Authors: Chrysant SG, Chrysant GS
Abstract
INTRODUCTION: Hyperhomocysteinemia has been considered as a risk factor for systemic atherosclerosis, cardiovascular disease (CVD) and stroke and many epidemiologic and case-controlled studies have demonstrated its association with these complications. In addition, treatment of hyperhomocysteinemia with folic acid ± B vitamins prevents the development of atherosclerosis, CVD and strokes. However, subsequent prospective, randomized, placebo- controlled trials have not shown an association of high homocysteine levels or their lowering with treatment with the incidence of at...
Source: Expert Review of Cardiovascular Therapy - July 8, 2018 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
A True Hematologic Emergency
BY GREGORY TAYLOR, DO, & JACKLYN MCPARLANE, DOA 33-year-old woman with a past medical history of sickle cell SS presented to the emergency department with chest pain, difficulty breathing, and a cough for two days. Her chest pain was diffuse, without radiation, and partially reproducible. Her cough was nonproductive, and she also reported fever and chills.The patient noted this was different from her normal back and leg pain from past sickle cell crises. She was following up with a sickle cell specialist, and was compliant with her hydroxyurea treatment.Her temperature was 102.8°F, blood pressure was 94/60 mm...
Source: The Case Files - June 26, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Supplements Won't Prevent Heart Disease: Study
There was one exception, researchers said. A more recent clinical trial in China found that folic acid supplements helped curb participants' risk of stroke.
Source: WebMD Health - May 29, 2018 Category: Consumer Health News Source Type: news
Most vitamin, mineral supplements not shown to lower heart disease risk
(American College of Cardiology) Current research does not show enough evidence that vitamin or mineral supplements are beneficial for preventing or treating heart disease, with the exception of folic acid for reducing stroke risk, according to a review article published in the Journal of the American College of Cardiology. Current recommendations to adopt healthy diets that are heavy in plant-based foods from which these vitamins are derived naturally should be reinforced.
Source: EurekAlert! - Medicine and Health - May 28, 2018 Category: International Medicine & Public Health Source Type: news
Hypertensive patients may benefit from folic acid supplements
Hypertensive adults with low platelet count who took a combined daily pill of both enalapril and folic acid saw a 73 percent reduction in their risk of first stroke compared to patients who took only enalapril daily, according to a study published in the Journal of the American College of Cardiology.
Source: World Pharma News - May 8, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
Folic Acid May Cut Stroke Risk in High-Risk Hypertensive Patients
MONDAY, May 7, 2018 -- Hypertensive patients may lower their stroke risk with folic acid supplements, according to a study published in the May 15 issue of the Journal of the American College of Cardiology.
Xiangyi Kong, M.D., from Peking University...
Source: Drugs.com - Pharma News - May 7, 2018 Category: Pharmaceuticals Source Type: news
The power of folic-acid: Supplements can slash a stroke by almost 75%
Researchers from Peking University found that adults with hypertension who take folic acid, alongside blood-pressure medication, every day for four years are 73 per cent less at risk of stroke.
Source: the Mail online | Health - May 7, 2018 Category: Consumer Health News Source Type: news
Correction to: Effect of Smoking and Folate Levels on the Efficacy of Folic Acid Therapy in Prevention of Stroke in Hypertensive Men Correction
Source: Stroke - February 26, 2018 Category: Neurology Tags: Corrections Source Type: research
Effect of Smoking and Folate Levels on the Efficacy of Folic Acid Therapy in Prevention of Stroke in Hypertensive Men Clinical Sciences
Conclusions—Baseline folate levels and smoking status can interactively affect the risk of first stroke. Our data suggest that compared with never smokers, ever smokers may require a higher dosage of folic acid to achieve a greater beneficial effect on stroke. Our findings need to be confirmed by future randomized trials.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT00794885.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Ziyi Zhou, Jianping Li, Yaren Yu, Youbao Li, Yan Zhang, Lishun Liu, Yun Song, Min Zhao, Yu Wang, Genfu Tang, Mingli He, Xiping Xu, Yefeng Cai, Qiang Dong, Delu Yin, Xiao Huang, Xiaoshu Cheng, Binyan Wang, Fan Fan Hou, Xiaobin Wang, Xianhui Qin, Yong Huo Tags: Primary Prevention, Hypertension, Treatment, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study
Conclusion:
In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062
Received: 14 April 2017
Revised: 13 November 2017
Accepted: 15 November 2017
Published: 15 December 2017
Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu
Supplemental Material is ava...
Source: EHP Research - December 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Association between percent decline in serum total homocysteine and risk of first stroke
Conclusions:
Percent lowering in tHcy was significantly associated with a reduction in first stroke risk in Chinese adults with hypertension, and if further confirmed, may serve as a useful indicator for folic acid treatment efficacy on stroke prevention.
Clinicaltrials.gov identifier:
NCT00794885.
Source: Neurology - November 13, 2017 Category: Neurology Authors: Huang, X., Li, Y., Li, P., Li, J., Bao, H., Zhang, Y., Wang, B., Sun, N., Wang, J., He, M., Yin, D., Tang, G., Chen, Y., Cui, Y., Huang, Y., Hou, F. F., Qin, X., Huo, Y., Cheng, X. Tags: Stroke prevention, All Clinical trials ARTICLE Source Type: research
Influence of renal function on the association between homocysteine level and risk of ischemic stroke.
We examined whether the association between total homocysteine (tHCY) and risk of ischemic stroke (IS) varies depending on renal function to gain insight into why tHCY-lowering vitamins do not reduce the incidence of cardiovascular disease in clinical trials. We analyzed data from 542 IS patients with large artery atherosclerosis (LAA) or small artery occlusion (SAO) after stratification by estimated glomerular filtration rate (eGFR) to evaluate renal function. We found that tHCY level was positively associated with the occurrence of IS in both LAA (OR: 1.159, 95% CI: 1.074-1.252, P<0.001) and SAO (OR: 1.143, 95% CI: 1....
Source: American Journal of Translational Research - November 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research
Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease.
CONCLUSIONS: Our meta-analysis demonstrated that folic acid supplementation is effective in stroke prevention in patients with CVD.
PMID: 29078842 [PubMed - in process]
Source: The American Journal of the Medical Sciences - October 1, 2017 Category: General Medicine Authors: Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL Tags: Am J Med Sci Source Type: research
