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Total 25 results found since Jan 2013.
Environmental enrichment enhanced neurogenesis and behavioral recovery after stroke in aged rats
CONCLUSIONS: EE improved post-stroke recovery on the basis of enhancing neurogenesis in aged rats.PMID:37688770 | DOI:10.18632/aging.205010
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Ji Yan Yan Liu Fangda Zheng Dan Lv Di Jin Source Type: research
Effective treatment of choreaballism due to an MT ‐CYB variant with haloperidol, tetrabenazine, and antioxidants
Cerebral CT showing bilateral putaminal calcifications of a patient with multisystem mitochondrial disorder due to the variant 15043G > A inMT-CYB. Key Clinical MessageHypokinetic and hyperkinetic movement disorders are a common phenotypic feature of mitochondrial disorders. Choreaballism has been reported particularly in patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome and in maternally inherited diabetes and deafness syndrome. The pathophysiological basis of movement disorders in mitochondrial disorders is the involvement of the basal ganglia or the midbrain. Haloper...
Source: Clinical Case Reports - June 21, 2023 Category: General Medicine Authors: Josef Finsterer,
Ritwik Ghosh Tags: CASE REPORT Source Type: research
Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis
In this study, Plasminogen activator, urokinase receptor (PLAUR) was identified as an effective diagnostic marker for AS lesion progression by combining WGCNA and random forest algorithm. We validated the stability of the diagnostic value on multiple external datasets including humans and mice. We identified a significant correlation between PLAUR expression and lesion progression. We mined multiple single cell-RNA sequencing (sc-RNA seq) data to nominate macrophage as the key cell cluster for PLAUR mediated lesion progression. We combined cross-validation results from multiple databases to predict that HCG17-hsa-miR-424-5...
Source: Atherosclerosis - May 26, 2023 Category: Cardiology Authors: Chengyi Dai Yuhang Lin Source Type: research
Neuroprotective effects of < em > Chrysanthemum morifolium < /em > on cerebral ischemia- reperfusion injury contributes to the oxidative stress suppression and related Keap1/Nrf2 pathway
CONCLUSION: CME could significantly reduce oxidative stress and nerve injury in vitro and in vivo models of CI/RI by regulating the Keap1/Nrf2 pathway.PMID:36567616 | DOI:10.1080/02699052.2022.2158225
Source: Brain Injury - December 26, 2022 Category: Neurology Authors: Zibin Zhang Xiaojun Pang Yuyu Wei Huai Chen Xuhong Jin Qingping Lv Source Type: research
Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation
ConclusionELAVL1 plays a critical role in protecting against ferroptosis-induced cerebral I/R and subsequent brain damage via DNMT3B/PINK1 axis, thus providing a new potential target for ischemic stroke treatment.
Source: Metabolic Brain Disease - December 1, 2022 Category: Neurology Source Type: research
Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1 β via circPDE4D/miR-4306/SOX9 cascade
CONCLUSION: CircPDE4D and miR-4306 were important regulators in regulating IL-1β-induced HNC apoptosis and matrix degradation via regulating the key transcription factor SOX9, suggesting a novel circPDE4D/miR-4306/SOX9 ceRNA pathway in OA-related chondrocyte dysfunction.PMID:35549803 | DOI:10.1080/08923973.2022.2077215
Source: Immunopharmacology and Immunotoxicology - May 13, 2022 Category: Allergy & Immunology Authors: Lixia Gao Xiaoyun Wang Jian Xiong Yan Ma Source Type: research
Preclinical Evidence and Possible Mechanisms of Rhodiola rosea L. and Its Components for Ischemic Stroke: A Systematic Review and Meta-Analysis
Conclusion: The findings suggested that RRC can improve ischemia stroke. The possible mechanisms of RRC are largely through antioxidant, anti-apoptosis activities, anti-inflammatory, repressing lipid peroxidation, antigliosis, and alleviating the pathological blood brain barrier damage.
Source: Frontiers in Pharmacology - November 5, 2021 Category: Drugs & Pharmacology Source Type: research
Knockdown of lncRNA SNHG15 Ameliorates Oxygen and Glucose Deprivation (OGD)-Induced Neuronal Injury via Regulating the miR-9-5p/TIPARP Axis
Biochem Genet. 2021 Aug 28. doi: 10.1007/s10528-021-10121-3. Online ahead of print.ABSTRACTStroke is a cerebrovascular disease with impaired nerve function. Long non-coding RNA (lncRNA) is considered to be an important regulator of various diseases. Nevertheless, the role of lncRNA small nucleolar RNA host gene 15 (SNHG15) in cerebral ischemia injury induced by stroke is still unclear. Cell-counting kit 8 assay and flow cytometry were used to detect cell viability and apoptosis, respectively. The caspase3 activity of cells was measured using Caspase3 Activity Assay Kit. Besides, the protein levels of apoptosis markers and ...
Source: Biochemical Genetics - August 28, 2021 Category: Genetics & Stem Cells Authors: Bin Shen Lan Wang Yuejun Xu Hongwei Wang Shiyi He Source Type: research
