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Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence.
Abstract The identification of the mechanisms predisposing to stroke may improve its preventive and therapeutic strategies in patients with essential hypertension. The role of macroautophagy/autophagy in the development of hypertension-related stroke needs to be clarified. We hypothesized that a defective autophagy may favor hypertension-related spontaneous stroke by promoting mitochondrial dysfunction. We studied autophagy in the stroke-prone spontaneously hypertensive (SHRSP) rat, which represents a clinically relevant model of stroke associated with high blood pressure. We assessed autophagy, mitophagy and NAD+...
Source: Autophagy - November 2, 2019 Category: Cytology Authors: Forte M, Bianchi F, Cotugno M, Marchitti S, De Falco E, Raffa S, Stanzione R, di Nonno F, Chimenti I, Palmerio S, Pagano F, Petrozza V, Micaloni A, Madonna M, Relucenti M, Torrisi MR, Frati G, Volpe M, Rubattu S, Sciarretta S Tags: Autophagy Source Type: research

The Stroke-Induced Increase of Somatostatin-Expressing Neurons is Inhibited by Diabetes: A Potential Mechanism at the Basis of Impaired Stroke Recovery.
Abstract Type 2 diabetes (T2D) hampers recovery after stroke, but the underling mechanisms are mostly unknown. In a recently published study (Pintana et al. in Clin Sci (Lond) 133(13):1367-1386, 2019), we showed that impaired recovery in T2D was associated with persistent atrophy of parvalbumin+ interneurons in the damaged striatum. In the current work, which is an extension of the abovementioned study, we investigated whether somatostatin (SOM)+ interneurons are also affected by T2D during the stroke recovery phase. C57Bl/6j mice were fed with high-fat diet or standard diet (SD) for 12 months and subjected to 30...
Source: Cellular and Molecular Neurobiology - May 22, 2020 Category: Cytology Authors: Chiazza F, Pintana H, Lietzau G, Nyström T, Patrone C, Darsalia V Tags: Cell Mol Neurobiol Source Type: research

Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats
This report investigates the role of PKa on hemorrhage and hypertension in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP were fed with a high salt-containing stroke-prone diet to increase blood pressure and induce intracerebral hemorrhage. The roles of PKa on blood pressure, hemorrhage, and survival in SHRSP were examined in rats receiving a PKa inhibitor or plasma prekallikrein antisense oligonucleotide (PK ASO) compared with rats receiving control ASO. Effects on PKa on the proteolytic cleavage of atrial natriuretic peptide (ANP) were analyzed by tandem mass spectrometry. We show that SHRSP on high-salt die...
Source: Cell Research - July 9, 2021 Category: Cytology Authors: Jian Guan Allen C Clermont Loc-Duyen Pham Tuna Ustunkaya Alexey S Revenko A Robert MacLeod Edward P Feener Fabr ício Simão Source Type: research

The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids
Cell Mol Neurobiol. 2022 Mar 28. doi: 10.1007/s10571-022-01209-4. Online ahead of print.ABSTRACTShort-chain fatty acids (SCFAs) are monocarboxylates produced by the gut microbiota (GM) and result from the interaction between diet and GM. An increasing number of studies about the microbiota-gut-brain axis (MGBA) indicated that SCFAs may be a crucial mediator in the MGBA, but their roles have not been fully clarified. In addition, there are few studies directly exploring the role of SCFAs as a potential regulator of microbial targeted interventions in ischemic stroke, especially for clinical studies. This review summarizes t...
Source: Cellular and Molecular Neurobiology - March 29, 2022 Category: Cytology Authors: Zongwei Fang Mingrong Chen Jiafen Qian Chunhua Wang Jinhua Zhang Source Type: research

Caloric restriction stabilizes body weight and accelerates behavioral recovery in aged rats after focal ischemia
In conclusion, our study shows that recovery from stroke is enhanced in aged rats by a dietary regimen that reduces body weight prior to infarct.
Source: Aging Cell - September 29, 2017 Category: Cytology Authors: Ovidiu Ciobanu, Raluca Elena Sandu, Adrian Tudor Balseanu, Alexandra Zavaleanu, Andrei Gresita, Eugen Bogdan Petcu, Adriana Uzoni, Aurel Popa ‐Wagner Tags: Original Article Source Type: research

An Enriched Environment Promotes Motor Function through Neuroprotection after Cerebral Ischemia
In this study, adult C57BL/6 mice after permanent middle cerebral artery occlusion (pMCAO) were assigned to the EE and standard housing (SH) groups 3 days after operation. The EE house was spacious that contained a large variety of small toys; the SH was a normal sized cage. Sham-operated mice without artery occlusion were housed under standard conditions and were fed a normal diet. On days 3, 7, 14, and 21, postoperative motor functional recovery was tested using the modified neurological severity score (mNSS) and the Rotarod test. The expression of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), growth-assoc...
Source: Cell Research - February 23, 2023 Category: Cytology Authors: Liang-Feng Shi Chuan-Jie Wang Ke-Wei Yu Jun-Fa Wu Qi-Qi Zhang Source Type: research

The ω‐3 fatty acid α‐linolenic acid extends Caenorhabditis elegans lifespan via NHR‐49/PPARα and oxidation to oxylipins
Summary The dietary intake of ω‐3 polyunsaturated fatty acids has been linked to a reduction in the incidence of aging‐associated disease including cardiovascular disease and stroke. Additionally, long‐lived Caenorhabditis elegans glp‐1 germ line‐less mutant animals show a number of changes in lipid metabolism including the increased production of the ω‐3 fatty acid, α‐linolenic acid (ALA). Here, we show that the treatment of C. elegans with ALA produces a dose‐dependent increase in lifespan. The increased longevity of the glp‐1 mutant animals is known to be dependent on both the NHR‐49/PPARα and S...
Source: Aging Cell - August 3, 2017 Category: Cytology Authors: Wenbo Qi, Gloria E. Gutierrez, Xiaoli Gao, Hong Dixon, Joe A. McDonough, Ann M. Marini, Alfred L. Fisher Tags: Original Article Source Type: research

Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H < sub > 2 < /sub > O < sub > 2 < /sub > -Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice
Conclusions: ALA could provide a potential treatment for atherosclerosis in postmenopausal patients.Cell Physiol Biochem 2018;47:2261 –2277
Source: Cellular Physiology and Biochemistry - July 5, 2018 Category: Cytology Source Type: research

ADAMTS5 deficiency in mice does not affect cardiac function.
This article is protected by copyright. All rights reserved. PMID: 30958594 [PubMed - as supplied by publisher]
Source: Cell Biology International - April 7, 2019 Category: Cytology Authors: Hemmeryckx B, Carai P, Lijnen H Tags: Cell Biol Int Source Type: research