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Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

The dietary transition and its association with cardiometabolic mortality among Chinese adults, 1982–2012: a cross-sectional population-based study
Publication date: Available online 10 May 2019Source: The Lancet Diabetes & EndocrinologyAuthor(s): Yuna He, Yanping Li, Xiaoguang Yang, Elena C Hemler, Yuehui Fang, Liyun Zhao, Jian Zhang, Zhenyu Yang, Zhu Wang, Li He, Jing Sun, Dong D Wang, Jingzhong Wang, Jianhua Piao, Xiaofeng Liang, Gangqiang Ding, Frank B HuSummaryBackgroundFew studies have used nationally representative data to describe dietary trends and the related cardiometabolic mortality burden in China. Thus, we aimed to characterise the trends in disease-related dietary factors as well as their associated disease burden among Chinese adults from 1982 to 2012....
Source: The Lancet Diabetes and Endocrinology - May 12, 2019 Category: Endocrinology Source Type: research

Greater macrovascular and microvascular morbidity from type 2 diabetes in Northern compared with Southern China: a cross ‐sectional study
ConclusionsMore macrovascular and microvascular complications were found in Northern compared to Southern patients, and the largest difference also appeared in the younger age groups under 55, which may be meaningful to a screening and treatment strategy according to geographic differences.
Source: Journal of Diabetes Investigation - March 31, 2020 Category: Endocrinology Authors: Li Wang, Ying Xing, Xinwen Yu, Jie Ming, Xiangyang Liu, Xiaomiao Li, Jianfang Fu, Jie Zhou, Bin Gao, Dayi Hu, Changyu Pan, Linong Ji, Qiuhe Ji Tags: ORIGINAL ARTICLE Source Type: research

Greater macrovascular and microvascular morbidity from type  2 diabetes in northern compared with southern China: A cross‐sectional study
ConclusionsMore macrovascular and microvascular complications were found in northern compared with southern patients, and the largest difference also appeared in the younger age groups<55  years, which might be meaningful to a screening and treatment strategy according to geographic differences.
Source: Journal of Diabetes Investigation - May 3, 2020 Category: Endocrinology Authors: Li Wang, Ying Xing, Xinwen Yu, Jie Ming, Xiangyang Liu, Xiaomiao Li, Jianfang Fu, Jie Zhou, Bin Gao, Dayi Hu, Changyu Pan, Linong Ji, Qiuhe Ji Tags: Original Article Source Type: research

Lead Anti-obesity Compounds from Nature.
Conclusion-Consumption of diets comprising high amounts of active anti-obesity natural compounds is a promising strategy for the suppression of lipid accumulation and adipogenesis in obese individuals. PMID: 32364084 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2020 Category: Endocrinology Authors: Dahiya V, Vasudeva N, Sharma S, Kumar A, Rowley D Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort
CONCLUSIONS: Pro-NT/NMN was associated with MetS and two components, dysglycemia and low HDL, likely explained by insulin resistance.PMID:34013344 | DOI:10.1210/clinem/dgab355
Source: The Journal of Clinical Endocrinology and Metabolism - May 20, 2021 Category: Endocrinology Authors: Charles D Nicoli April P Carson Timothy B Plante D Leann Long Leslie A McClure Janin Schulte Mary Cushman Source Type: research

Developmental Origins of Metaflammation; A Bridge to the Future Between the DOHaD Theory and Evolutionary Biology
Metabolic syndrome refers to obesity-associated metabolic disorders that increase the risk of type 2 diabetes, coronary diseases, stroke, and other disabilities. Environmental imbalance during the early developmental period affects health and increases susceptibility to non-communicable diseases, including metabolic syndrome, in later life; therefore, the Developmental Origins of Health and Disease (DOHaD) theory was established. According to the DOHaD theory, the hypothesis of the energy-saving ‘Thrifty Phenotype’ in undernourished fetuses is one of the well-accepted schemes as a risk of developing metabolic syndrome....
Source: Frontiers in Endocrinology - February 3, 2022 Category: Endocrinology Source Type: research

RSSDI consensus recommendations for dyslipidemia management in diabetes mellitus
AbstractDiabetic dyslipidemia is characterised by low HDL-C and high triglyceride levels. Unlike the Caucasian population, though LDL-C levels are not very high, there is a preponderance of more atherogenic small, dense LDL particles among Indians. Furthermore, apo B levels are elevated. This, unique ‘atherogenic dyslipidemia’, is frequently encountered in South Asians with diabetes. People with type 2 diabetes are considered to be at high risk for vascular events. Hence, irrespective of other risk factors such as age, male gender, hypertension, family history, smoking, obesity, and polycyst ic ovary syndrome in women,...
Source: International Journal of Diabetes in Developing Countries - April 7, 2022 Category: Endocrinology Source Type: research

Dietary genistein and 17 β-estradiol implants differentially influence locomotor and cognitive functions following transient focal ischemia in middle-aged ovariectomized rats at different lengths of estrogen deprivation
This study suggests that the neuroprotective effects of dietary genistein on motor and cognitive functions are distinctly influenced by the length of estrogen deprivation following focal ischemia. SIGNIFICANCE: There is an increasing postmenopausal population opting for homeopathic medicines for the management of menopausal symptoms due to the perceived distrust in estrogen use as hormone replacement. Basic and clinical studies support the notion that early, but not delayed, hormone replacement after menopause is beneficial. Furthermore, evidence suggests that delaying hormone replacement augments the detrimental, rather t...
Source: Hormones and Behavior - June 2, 2022 Category: Endocrinology Authors: Anthony Oppong-Gyebi Daniel Metzger Philip H Vann Nathalie Sumien Derek A Schreihofer Source Type: research

Gut microbiota is a potential goalkeeper of dyslipidemia
Dyslipidemia, as a common metabolic disease, could cause atherosclerosis, coronary heart disease, stroke and other cardio-cerebrovascular diseases. It is mainly caused by the interaction of genetic and environmental factors and its incidence has increased for several years. A large number of studies have shown that gut microbiota disorder is related to the development of dyslipidemia closely. Especially its metabolites such as short-chain fatty acids, bile acids and trimethylamine N-oxide affect dyslipidemia by regulating cholesterol balance. In this paper, we systematically reviewed the literature and used knowledge graph...
Source: Frontiers in Endocrinology - September 13, 2022 Category: Endocrinology Source Type: research

Differences in the choroid plexus volume and microstructure are associated with body adiposity
The choroid plexus (CP) is a cerebral structure located in the ventricles that functions in producing most of the brain’s cerebrospinal fluid (CSF) and transporting proteins and immune cells. Alterations in CP structure and function has been implicated in several pathologies including aging, multiple sclerosis, Alzheimer’s disease, and stroke. However, identification of changes in the CP remains poorly characterized in obesity, one of the main risk factors of neurodegeneration, including in the absence of frank central nervous system alterations. Our goal here was to characterize the association between obesity, measur...
Source: Frontiers in Endocrinology - October 13, 2022 Category: Endocrinology Source Type: research

Trimethylamine N-Oxide as a potential risk factor for non-communicable diseases: A systematic review
CONCLUSION: There is a dose-response relationship between TMAO levels and NCDs progression. Therefore, it can be studied as a therapeutic target or prognostic biomarker for dealing with NCDs.PMID:36330632 | DOI:10.2174/1871530323666221103120410
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - November 4, 2022 Category: Endocrinology Authors: Zahra Hoseini Tavassol Hanieh-Sadat Ejtahed Bagher Larijani Shirin Hasani-Ranjbar Source Type: research

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