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Nutrition: Diets

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Total 102 results found since Jan 2013.

Mechanism of Tao Hong Decoction in the treatment of atherosclerosis based on network pharmacology and experimental validation
CONCLUSION: THD plays a vital role in treating AS with multiple targets and pathways. Angiogenesis regulation, oxidative stress regulation, and immunity regulation consist of the crucial regulation cores in the mechanism. This study identified essential genes and pathways associated with the prognosis and pathogenesis of AS from new insights, demonstrating a feasible method for researching THD's chemical basis and pharmacology.PMID:36776258 | PMC:PMC9909180 | DOI:10.3389/fcvm.2023.1111475
Source: Atherosclerosis - February 13, 2023 Category: Cardiology Authors: SiJin Li Ping Liu Xiaoteng Feng Min Du Yifan Zhang YiRu Wang JiaRou Wang Source Type: research

Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice
FASEB J. 2023 Mar;37(3):e22752. doi: 10.1096/fj.202200056R.ABSTRACTAtherosclerosis is a chronic inflammatory condition of our arteries and the main underlying pathology of myocardial infarction and stroke. The pathogenesis is age-dependent, but the links between disease progression, age, and atherogenic cytokines and chemokines are incompletely understood. Here, we studied the chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) in atherogenic Apoe-/- mice across different stages of aging and cholesterol-rich high-fat diet (HFD). MIF promotes atherosclerosis by mediating leukocyte recruitment, ...
Source: Atherosclerosis - February 16, 2023 Category: Cardiology Authors: Christine Krammer Bishan Yang Sabrina Reichl Simon Besson-Girard Hao Ji Verena Bolini Corinna Schulte Heidi Noels Kai Schlepckow Georg Jocher Georg Werner Michael Willem Omar El Bounkari Aphrodite Kapurniotu Ozgun Gokce Christian Weber Sarajo Mohanta J ü Source Type: research

The role of gut-dependent molecule trimethylamine N-oxide as a novel target for the treatment of chronic kidney disease
Int Urol Nephrol. 2023 Feb 16. doi: 10.1007/s11255-023-03500-9. Online ahead of print.ABSTRACTTrimethylamine N-oxide (TMAO) is an intestinal uremic toxin molecule mainly excreted by the kidney. Therefore, the plasma TMAO concentration is significantly increased in chronic kidney disease (CKD) patients, and plasma TMAO can be cleared by dialysis. Furthermore, TMAO damage the kidney mainly through three mechanisms: oxidative stress, inflammation and endoplasmic reticulum stress. Clinical experiments have indicated that higher TMAO levels are strongly related to the elevated incidence and mortality of cardiovascular (CV) even...
Source: Atherosclerosis - February 16, 2023 Category: Cardiology Authors: Sai Pan Delong Zhao Shuwei Duan Xiangmei Chen Source Type: research

A Potential Strategy for Atherosclerosis Prevention in Modernizing China - Hyperhomocysteinemia, MTHFR C677T Polymorphism and Air Pollution (PM2.5) on Atherogenesis in Chinese Adults
CONCLUSION: HC and PM2.5 pollution but not MTHFR genotype were both related to carotid IMT, independent of other traditional risk factors. This has potential implications in dietary and AP strategies for atherosclerosis prevention in China.PMID:36806868 | DOI:10.1007/s12603-023-1889-x
Source: Atherosclerosis - February 22, 2023 Category: Cardiology Authors: C Y T Kwok Y K P Poon P Chook D S Guo C Q Lin Y H Yin D S Celermajer K S Woo Source Type: research

Atherosclerotic patients with diabetes mellitus may break through the threshold of healthy TMAO levels formed by long-term statins therapy
CONCLUSION: Diabetics have abnormally high plasma TMAO levels even under continuous statins treatment, which may contribute to the development and progression of atherosclerosis. Therefore, it is necessary to focus on monitoring TMAO levels in diabetic patients to reduce adverse cardiovascular events in diabetic patients.PMID:36879744 | PMC:PMC9984437 | DOI:10.1016/j.heliyon.2023.e13657
Source: Atherosclerosis - March 7, 2023 Category: Cardiology Authors: Hao Liang Anqi Yu Zheng Wang Na Zhang Qingsong Wang Haichao Gao Junhui Gao Xinjun Wang Hong Wang Source Type: research

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets
Chin J Integr Med. 2023 Mar 13. doi: 10.1007/s11655-023-3545-z. Online ahead of print.ABSTRACTThe prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia can lead to a range of diseases such as atherosclerosis, stroke, coronary heart disease, myocardial infarction, diabetes, and kidney failure, etc. High circulating low-density lipoprotein cholesterol (LDL-C) is one of the causes of hyperlipidemia. LDL-C in the blood binds to LDL receptor (LDLR) and regulates cholesterol...
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Su-Su Liu Tong Yu Yan-Fang Qiao Shu-Xiao Gu Xin-Lou Chai Source Type: research

Changes in Cardiovascular Health Across Midlife and Late-Life and Magnetic Resonance Imaging Markers of Cerebral Vascular Disease in Late-Life
CONCLUSIONS: Improving cardiovascular health within midlife and from midlife to late-life may prevent development of cerebral vascular disease.PMID:36951053 | DOI:10.1161/STROKEAHA.122.041374
Source: Atherosclerosis - March 23, 2023 Category: Cardiology Authors: Sanaz Sedaghat Yuekai Ji Jean-Philippe Empana Timothy M Hughes Thomas H Mosley Rebecca F Gottesman Michael Griswold Clifford R Jack Pamela L Lutsey Thomas T van Sloten Source Type: research

Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis
PLoS One. 2023 May 10;18(5):e0285253. doi: 10.1371/journal.pone.0285253. eCollection 2023.ABSTRACTAtherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is sensitive to changes in shear stress. Here, using atheroprone, ApoE-/- mice, with a single allele deletion of Arf6 (HET) or wildtype Arf6 (WT), we demonstrate that reduction in Arf6 attenuates atherosclerotic plaque burden and severity. We found that plaque burden in the descending...
Source: Atherosclerosis - May 10, 2023 Category: Cardiology Authors: Venkateswara R Gogulamudi Md Torikul Islam Jessica R Durrant Adelola O Adeyemo Daniel W Trott Mi Ho Hyuhn Weiquan Zhu Anthony J Donato Ashley E Walker Lisa A Lesniewski Source Type: research

Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Atherosclerosis - May 11, 2023 Category: Cardiology Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research

Acrolein: formation, health hazards and its controlling by dietary polyphenols
Crit Rev Food Sci Nutr. 2023 May 19:1-14. doi: 10.1080/10408398.2023.2214625. Online ahead of print.ABSTRACTAcrolein, a highly reactive toxic aldehyde, is a common dietary and environmental contaminant which can also be generated endogenously. Exposure to acrolein has been positively associated with some pathological conditions, such as atherosclerosis, diabetes mellitus, stroke, and Alzheimer's disease. At the cellular level, acrolein induces various harmful effects, particularly protein adduction and oxidative damages. Polyphenols are a group of secondary plant metabolites ubiquitously presented in fruits, vegetables, an...
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Yue Zhou Wendy Jin Qingli Wu Qian Zhou Source Type: research

Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis
CONCLUSION: We here conclude that in hyperlipidemic ApoE-/- mice, B cell specific TNIK deficiency does not affect atherosclerosis.PMID:37215541 | PMC:PMC10196212 | DOI:10.3389/fcvm.2023.1171764
Source: Atherosclerosis - May 22, 2023 Category: Cardiology Authors: Bram W van Os Pascal J H Kusters Myrthe den Toom Linda Beckers Claudia M van Tiel Winnie G Vos Elize de Jong Arnd Kieser Cindy van Roomen Christoph J Binder Myrthe E Reiche Menno P de Winther Laura A Bosmans Esther Lutgens Source Type: research

Effectiveness of Internet-based health management in patients with dyslipidemia: A four-year longitudinal study
CONCLUSIONS: The basic Internet-based health management platform in this study appears to be moderately successful and is a valuable and feasible application. Tobacco, dietary, and physical activity interventions provided significant protection against dyslipidemia in patients.PMID:37279608 | DOI:10.1016/j.atherosclerosis.2023.04.004
Source: Atherosclerosis - June 6, 2023 Category: Cardiology Authors: Yuqi Dou Botian Chen Xue Yu Defu Ma Source Type: research

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