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Source: Atherosclerosis
Nutrition: Diets

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Total 102 results found since Jan 2013.

A Comorbid Rat Model of Neuroendocrine-Immune System Alterations Under the Impact of Risk Factors for Stroke
Front Aging Neurosci. 2022 Jan 20;13:827503. doi: 10.3389/fnagi.2021.827503. eCollection 2021.ABSTRACTHypercholesterolemia and carotid atherosclerosis contribute to the etiology of stroke. However, there has been a lack of appropriate comorbid animal models incorporating some of the ubiquitous characteristics that precede strokes. Curcumin is a natural active polyphenolic compound extracted from the rhizoma of Curcuma longa L. which possesses comprehensive bioactivities. The present study aimed to evaluate whether neurobehavioral deficits, neuroendocrine-immune dysregulations and cerebral microcirculation dysfunction, are ...
Source: Atherosclerosis - February 7, 2022 Category: Cardiology Authors: Bailiu Ya Xuezhi Li Jingyi Wang Mingsheng Zhao Ting Yu Haiying Wang Qing Xin Qinqin Wang Xin Mu Xuanyu Dong Yang Gao Huabao Xiong Hui Zhang Source Type: research

Mediterranean-style diet and intracranial large artery stenosis in the Northern Manhattan Study
CONCLUSION: In this stroke-free subsample, we did not find a significant association between MeDi and ICAS. We may have been limited by statistical power.PMID:37634256 | DOI:10.1016/j.jstrokecerebrovasdis.2023.107252
Source: Atherosclerosis - August 27, 2023 Category: Cardiology Authors: Dixon Yang Hannah Gardener Farid Khasiyev Tatjana Rundek Clinton B Wright Mitchell Sv Elkind Jose Gutierrez Source Type: research

Peripheral Vascular Disease and Carotid Artery Disease Are Associated with Decreased Bile Acid Excretion
This study investigated BAE in patients with peripheral vascular disease (PVD) and carotid artery disease (CA) and those without these diseases, compared to patients with CAD, stroke, or no evidence of atherosclerosis. Patients with complaints of chest pain-suspected CAD, syncope, stroke/TIA, severe headache, intermittent claudication, or falls were enrolled. All received a 4-day standard diet with 490 mg of cholesterol and internal standard copper thiocyanate. Fecal BAE was measured using gas-liquid chromatography. One hundred and three patients, sixty-eight (66%) men and thirty-five women (34%), mean age range 60.9 ± 8....
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Lior Charach Gideon Charach Eli Karniel Leonid Galin Dorin Bar Ziv Lior Grossman Irit Kaye Itamar Grosskopf Source Type: research

Dog models of human atherosclerotic cardiovascular diseases
Mamm Genome. 2022 Oct 15. doi: 10.1007/s00335-022-09965-w. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Eighty-five percent of CVD-associated deaths are due to heart attacks and stroke. Atherosclerosis leads to heart attack and stroke through a slow progression of lesion formation and luminal narrowing of arteries. Dogs are similar to humans in terms of their cardiovascular physiology, size, and anatomy. Dog models have been developed to recapitulate the complex phenotype of human patients and understand the underlying mechanism of CVD. Different methods, inc...
Source: Atherosclerosis - October 15, 2022 Category: Cardiology Authors: Hui Zhao Enqi Liu Yong Q Zhang Source Type: research

IL-19 Regulates Atherosclerotic Plaque Progression via Lymphangiogenesis
CONCLUSION & SUMMARY: These data suggest that IL-19 increases lymphatic vessel formation, potentially allowing RCT to take place to decrease plaque burden in atherosclerosis. Further studies will confirm IL-19's mechanistic pathway in LECs. We will also determine RCT and inflammatory cell trafficking by intravital microscopy. These results have the potential to shift our understanding toward a positive view of the association between the lymphatic system and atherosclerosis.PMID:35554476 | DOI:10.1096/fasebj.2022.36.S1.R5435
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Amanda Peluzzo Kyle Preston Tani Leigh Sheri Kelemen Michael Autieri Source Type: research

Atherosclerosis risk factor management - what's new for the neurologist?
Arq Neuropsiquiatr. 2022 May;80(5 Suppl 1):88-93. doi: 10.1590/0004-282X-ANP-2022-S102.ABSTRACTStroke is the second leading cause of death worldwide and the vast majority can be attributed to modifiable risk factors, mainly behavioral and metabolic. The top six risk factors responsible for cardiovascular mortality in Brazil in 2019 were high systolic blood pressure, inadequate dietary exposure, high body mass index, high LDL cholesterol, high fasting blood glucose levels, and tobacco. We intend to discuss in this paper the evidence and recommendations in the approach of three essential risk factors for patients with a hist...
Source: Atherosclerosis - August 17, 2022 Category: Cardiology Authors: Luciana Dornfeld Bichuette Marcos Pita Lottenberg Francisco Akira Malta Cardozo Daniela Calderaro Source Type: research

Dengyinnaotong attenuates atherosclerotic lesions, gut dysbiosis and intestinal epithelial barrier impairment in the high fat diet-fed ApoE < sup > -/- < /sup > mice
CONCLUSIONS: Our work provides novel preclinical evidence that underpins the multifaceted effects of DYNT in the control of atherosclerosis.PMID:37453620 | DOI:10.1016/j.jep.2023.116916
Source: Atherosclerosis - July 15, 2023 Category: Cardiology Authors: Minqi Xiong Zilong Zhang Jingang Cui Xiaoye Du Yu Chen Teng Zhang Source Type: research

DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE < sup > -/- < /sup > mice via suppressing inflammation, endothelial necroptosis and apoptosis
This study aims to explore whether NBP is able to improve endothelium-dependent vasodilation in atherosclerosis and the underlying mechanisms. Male ApoE-/- mice were fed with a high-fat diet (HFD) for 9-16 weeks to establish a model of atherosclerosis. NBP were given to the mice after eating HFD for 6 weeks and atorvastatin served as a positive control. The endothelium-dependent vasodilation, the blood flow velocity, the atherosclerotic lesion area, the serum levels of lipids, inflammatory cytokines and necroptosis-relevant proteins (RIPK1, RIPK3 and MLKL), and the endothelial necroptosis and apoptosis within the aorta wer...
Source: Atherosclerosis - August 3, 2023 Category: Cardiology Authors: Li-Qun Lu Nian-Sheng Li Ming-Rui Li Jiao-Yang Peng Li-Jing Tang Xiu-Ju Luo Jun Peng Source Type: research

Diet, microparticles and atherothrombosis.
Abstract Cardiovascular disease is the main cause of death worldwide, and is principally caused by atherosclerosis, with subsequent thrombus formation, eventually provoking an acute myocardial infarction or a stroke. The formation and progression of the atherosclerotic plaques responds to multiple factors including certain diets. Intensive research has elucidated the role of diet in cardiovascular disease and has led to public health policies focusing on educating the population on the role of nutrition in cardiovascular health. Compelling evidence shows that a healthy diet, rich in fruit and vegetables with moder...
Source: Atherosclerosis - September 22, 2017 Category: Cardiology Authors: Badimon L, Suades R, Crespo J, Padro T, Chiva-Blanch G Tags: Front Biosci (Landmark Ed) Source Type: research

Identification of Mep1a as a susceptibility gene for atherosclerosis in mice
Genetics. 2021 Sep 29:iyab160. doi: 10.1093/genetics/iyab160. Online ahead of print.ABSTRACTAtherosclerosis is the underlying cause of heart attack, ischemic stroke and peripheral arterial disease, and genetic factors involved remain mostly unidentified. We previously identified a significant locus on mouse chromosome 17 for atherosclerosis, Ath49, in an intercross between BALB/c and SM strains. Ath49 partially overlaps in the confidence interval with Ath22 mapped in an AKR × DBA/2 intercross. Bioinformatics analysis prioritized Mep1a, encoding meprin 1α metalloendopeptidase, as a likely candidate gene for Ath49. To prov...
Source: Atherosclerosis - December 1, 2021 Category: Cardiology Authors: Andrew T Grainger Nathanael Pilar Jun Li Mei-Hua Chen Ashley M Abramson Christoph Becker-Pauly Weibin Shi Source Type: research

Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism
Front Cardiovasc Med. 2021 Nov 23;8:768481. doi: 10.3389/fcvm.2021.768481. eCollection 2021.ABSTRACTHigh-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional ...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Umar R Rekhi Mohamed Omar Maria Alexiou Cole Delyea Linnet Immaraj Shokrollah Elahi Maria Febbraio Source Type: research