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Source: Atherosclerosis
Nutrition: Diets

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Total 102 results found since Jan 2013.

Imaging High-Risk Atherothrombosis Using a Novel Fibrin-Binding Positron Emission Tomography Probe
CONCLUSIONS: We demonstrated that molecular fibrin PET imaging using 68Ga-CM246 could be a useful tool to diagnose experimental and clinical atherothrombosis. Based on our initial results using human carotid plaque specimens, in vivo molecular imaging studies are warranted to test 68Ga-CM246 PET as a tool to stratify risk in atherosclerotic patients.PMID:34965737 | DOI:10.1161/STROKEAHA.121.035638
Source: Atherosclerosis - December 30, 2021 Category: Cardiology Authors: David Izquierdo-Garcia Himashinie Diyabalanage Ian A Ramsay Nicholas J Rotile Adam Mauskapf Ji-Kyung Choi Thomas Witzel Valerie Humblet Farouc A Jaffer Anna-Liisa Brownell Ahmed Tawakol Ciprian Catana Mark F Conrad Peter Caravan Ilknur Ay Source Type: research

Prospective Comparison of Plasma Biomarker and Traditional Risk Factor Profiles for Incident Isolated Atherosclerotic Disease and Incident Isolated Abdominal Aortic Aneurysm
Conclusions: The data supports the view that components of vascular inflammation and cardiovascular stress drives AAA development, whereas glycated cross-links in abdominal aortic wall tissue may have a plausible role in reducing AAA risk in individuals with DM.PMID:35097031 | PMC:PMC8790118 | DOI:10.3389/fcvm.2021.818656
Source: Atherosclerosis - January 31, 2022 Category: Cardiology Authors: Stefan Acosta Shahab Fatemi Olle Melander Gunnar Engstr öm Anders Gotts äter Source Type: research

Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B
In conclusion, our data suggests that AIRE is not involved in regulating thymic expression of ApoB or atherosclerosis. Alternative mechanisms how ApoB-reactive CD4 T cells are selected in the thymus will have to be investigated.PMID:35097028 | PMC:PMC8792778 | DOI:10.3389/fcvm.2021.812769
Source: Atherosclerosis - January 31, 2022 Category: Cardiology Authors: Felix Sebastian Nettersheim Simon Braumann Kouji Kobiyama Marco Orecchioni Melanie Vassallo Jacqueline Miller Amal Ali Payel Roy Ryosuke Saigusa Dennis Wolf Klaus Ley Holger Winkels Source Type: research

How Single-Cell Technologies Have Provided New Insights Into Atherosclerosis
Arterioscler Thromb Vasc Biol. 2022 Feb 3:ATVBAHA121315849. doi: 10.1161/ATVBAHA.121.315849. Online ahead of print.ABSTRACTThe development of innovative single-cell technologies has allowed the high-dimensional transcriptomic and proteomic profiling of individual blood and tissue cells. Recent single-cell studies revealed a new cellular heterogeneity of atherosclerotic plaque tissue and allowed a better understanding of distinct immune functional states in the context of atherosclerosis. In this brief review, we describe how single-cell technologies have shed a new light on the cellular composition of atherosclerotic plaqu...
Source: Atherosclerosis - February 3, 2022 Category: Cardiology Authors: Natalia Eberhardt Chiara Giannarelli Source Type: research

Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice
This study was designed to explore the effects of TMAO on neuroinflammation, brain injury severity, and long-term neurologic function in mice with acute intracerebral hemorrhage (ICH). We fed mice with either a regular chow diet or a chow diet supplemented with 1.2% choline pre- and post-ICH. In this study, we measured serum levels of TMAO with ultrahigh-performance liquid chromatography-tandem mass spectrometry at 24 h and 72 h post-ICH. The expression level of P38-mitogen-protein kinase (P38-MAPK), myeloid differentiation factor 88 (MyD88), high-mobility group box1 protein (HMGB1), and interleukin-1β (IL-1β) around hem...
Source: Atherosclerosis - March 4, 2022 Category: Cardiology Authors: Caizhen Li Li Zhu Yinming Dai Zhiying Zhang Leo Huang Tom J Wang Peiji Fu Yinuo Li Jian Wang Chao Jiang Source Type: research

Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice
Genes (Basel). 2022 Mar 14;13(3):510. doi: 10.3390/genes13030510.ABSTRACTType 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. Apoe-null (Apoe-/-) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ Apoe-/- mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genoty...
Source: Atherosclerosis - March 25, 2022 Category: Cardiology Authors: Lisa J Shi Bilhan Chagari Alexander An Mei-Hua Chen Yongde Bao Weibin Shi Source Type: research

Genetic connection of carotid atherosclerosis with coat color and body weight in an intercross between hyperlipidemic mouse strains
Physiol Genomics. 2022 Apr 6. doi: 10.1152/physiolgenomics.00006.2022. Online ahead of print.ABSTRACTAtherosclerosis in the carotid artery is a major cause of ischemic stroke and has a strong genetic component. The aim of this study was to identify genetic factors contributing to carotid atherosclerosis. 154 female F2mice were generated from an intercross between LP/J and BALB/cJ Apoe-null (Apoe-/-) mice and fed 12 weeks of Western diet. Atherosclerotic lesions, body weight, and coat color were measured and genotyping was performed using miniMUGA arrays. A significant QTL on chromosome (Chr) 7, named Cath20, and 5 suggesti...
Source: Atherosclerosis - April 6, 2022 Category: Cardiology Authors: Bilhan Chagari Lisa J Shi Evelyn Dao Alexander An Mei-Hua Chen Yongde Bao Weibin Shi Source Type: research

Apolipoprotein C3-Rich Low-Density Lipoprotein Induces Endothelial Cell Senescence via FBXO31 and Its Inhibition by Sesamol In Vitro and In Vivo
In this study, we aimed to examine the effects of ApoC3-rich low-density lipoprotein (AC3RL) mediated via FBXO31 on endothelial cell (EC) senescence and its inhibition by sesamol. AC3RL and ApoC3-free low-density lipoproteins (LDL) (AC3(-)L) were isolated from the plasma LDL of patients with ischemic stroke. Human aortic endothelial cells (HAECs) treated with AC3RL induced EC senescence in a dose-dependent manner. AC3RL induced HAEC senescence via DNA damage. However, silencing FBXO31 attenuated AC3RL-induced DNA damage and reduced cellular senescence. Thus, FBXO31 may be a novel therapeutic target for endothelial senescen...
Source: Atherosclerosis - April 23, 2022 Category: Cardiology Authors: Ping-Hsuan Tsai Li-Zhen Chen Kuo-Feng Tseng Fang-Yu Chen Ming-Yi Shen Source Type: research

Exploring the Role of Irrational Beliefs, Lifestyle Behaviors, and Educational Status in 10-Year Cardiovascular Disease Risk: the ATTICA Epidemiological Study
CONCLUSIONS: The findings of this study underline the need to build new, holistic approaches in order to better understand the inter-relationships between irrational beliefs, lifestyle behaviors, social determinants, and CVD risk in individuals.PMID:35474416 | DOI:10.1007/s12529-022-10091-9
Source: Atherosclerosis - April 27, 2022 Category: Cardiology Authors: Christina Vassou Ekavi N Georgousopoulou Mary Yannakoulia Christina Chrysohoou Charalabos Papageorgiou Christos Pitsavos Mark Cropley Demosthenes B Panagiotakos Source Type: research

Could "cellular exercise" be the missing ingredient in a healthy life? Diets, caloric restriction, and exercise-induced hormesis
Nutrition. 2022 Feb 7;99-100:111629. doi: 10.1016/j.nut.2022.111629. Online ahead of print.ABSTRACTOvernutrition is a poor dietary habit that has been correlated with increased health risks, especially in the developed world. This leads to an imbalance between energy storage and energy breakdown. Many biochemical processes involving hormones are involved in conveying the excess of energy into pathologic states, mainly atherosclerosis, hypertension, cardiovascular diseases, and diabetes. Diverse modalities of regular exercise have been shown to be beneficial, to varying extents, in overcoming the overnutrition comorbidities...
Source: Atherosclerosis - April 30, 2022 Category: Cardiology Authors: Iv John L Pinches Yiuing L Pinches John O Johnson Natasha C Haddad Myriam G Boueri Luc M Oke Georges E Haddad Source Type: research

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