Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B

In conclusion, our data suggests that AIRE is not involved in regulating thymic expression of ApoB or atherosclerosis. Alternative mechanisms how ApoB-reactive CD4 T cells are selected in the thymus will have to be investigated.PMID:35097028 | PMC:PMC8792778 | DOI:10.3389/fcvm.2021.812769

Source: Atherosclerosis - January 31, 2022 Category: Cardiology Authors: Felix Sebastian Nettersheim Simon Braumann Kouji Kobiyama Marco Orecchioni Melanie Vassallo Jacqueline Miller Amal Ali Payel Roy Ryosuke Saigusa Dennis Wolf Klaus Ley Holger Winkels Source Type: research