• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Low-fat dietary pattern and cardiovascular disease: results from the Womens Health Initiative randomized controlled trial Cardiovascular disease risk
Conclusions: CVD risk in postmenopausal women appears to be sensitive to a change to a low-fat dietary pattern and, among healthy women, includes both CHD benefit and stroke risk. This trial was registered at clinicaltrials.gov as NCT00000611.
Source: American Journal of Clinical Nutrition - July 3, 2017 Category: Nutrition Authors: Prentice, R. L., Aragaki, A. K., Van Horn, L., Thomson, C. A., Beresford, S. A., Robinson, J., Snetselaar, L., Anderson, G. L., Manson, J. E., Allison, M. A., Rossouw, J. E., Howard, B. V. Tags: Obesity and Metabolism Research Articles Cardiovascular disease risk Source Type: research

Does diet map with mortality? Ecological association of dietary patterns with chronic disease mortality and its spatial dependence in Switzerland
Br J Nutr. 2021 May 11:1-27. doi: 10.1017/S0007114521001525. Online ahead of print.ABSTRACTThe aim of the study was to investigate the associations between dietary patterns and chronic disease mortality in Switzerland using an ecologic design and to explore the spatial dependence of these associations, i.e. the tendency of near locations to present more similar values than randomly expected and distant locations to present more different values. Data of the cross-sectional National Nutrition Survey menuCH (n = 2,057) were used to compute hypothesis- (Alternate Healthy Eating Index, AHEI) and data-driven dietary patterns. D...
Source: The British Journal of Nutrition - May 11, 2021 Category: Nutrition Authors: Giulia Pestoni Nena Karavasiloglou Julia Braun Jean-Philippe Krieger Janice M Sych Matthias Bopp David Faeh Oliver Gruebner Sabine Rohrmann Source Type: research

Dietary Magnesium and Chronic Disease
Publication date: May 2018 Source:Advances in Chronic Kidney Disease, Volume 25, Issue 3 Author(s): Forrest H. Nielsen Although official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement. This moderate or marginal (subclinical) deficient Mg intake generally is asymptomatic. Animal studies, however, indicate that moderate or subclinical Mg deficiency primes phagocytic cells for the release of proinflammatory cytokines leading to chronic inflammatory and oxidative stress. Human studies have found that dietary ...
Source: Advances in Chronic Kidney Disease - June 29, 2018 Category: Urology & Nephrology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research