Masthead
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Diabetes and the Kidney: Sweet Dreams
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): James E. Novak, Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Diabetic Kidney Disease (c. 2018)
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Katherine R. Tuttle (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

The Global Epidemiology of Diabetes and Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Digsu N. Koye, Dianna J. Magliano, Robert G. Nelson, Meda E. PavkovThe prevalence of diabetes is increasing worldwide, with the greatest increases occurring in low- and middle-income countries. In most developed countries, type 2 diabetes is presently the leading cause of end-stage renal disease and also contributes substantially to cardiovascular disease. In countries with weaker economies type 2 diabetes is rapidly replacing communicable diseases as a leading cause of kidney disease and is increasingly competing for scarc...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Competing Risk of Death With End-Stage Renal Disease in Diabetic Kidney Disease
We present an example taken from the Action to Control Cardiovascular Risk in Diabetes, a randomized trial of people with type 2 diabetes at high risk for cardiovascular disease. Participants were stratified according to baseline markers of kidney disease: (1) no kidney disease; (2) low estimated glomerular filtration rate; (3) microalbuminuria alone; and (4) macroalbuminuria. The macroalbuminuria group had the highest risk for ESRD and demonstrated the most marked difference between the Kaplan-Meier and cumulative incidence estimator. Cox and Fine-Gray regression models yielded similar risk estimates for baseline characte...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Glycemic Control as Primary Prevention for Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Richard J. MacIsaac, George Jerums, Elif I. EkinciImproving strategies to prevent the development and progression of CKD is a highly desirable outcome for all involved in the care of patients with diabetes. This is because CKD is a major factor contributing to morbidly and mortality in patients with diabetes. Furthermore, diabetes is the leading cause of ESRD in most developed countries. Although tight glucose control is now an established modality for preventing the development and progression of albuminuria, evidence is n...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

New Glucose-Lowering Agents for Diabetic Kidney Disease
In conclusion, currently available trials have demonstrated renoprotective effects for certain glucagon-like peptide-1 receptor agonists, liraglutide and semaglutide, and the sodium-glucose cotransporter 2 inhibitors, empagliflozin and canagliflozin. Dipeptidyl peptidase-4 inhibitors did not show a significant renoprotective effect. Nevertheless, larger studies with respect to renoprotective effects of these 3 drug classes are currently being performed, and thus, no conclusions for all of these agents can yet be made. (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Treatment of Diabetic Kidney Disease With Hypertension Control and Renin Angiotensin System Inhibition
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Vikram Patney, Kunal Chaudhary, Adam Whaley-ConnellThe global incidence and prevalence of diabetes continues to expand due primarily to the influences of obesity and the contribution of obesity to the progression of type 2 diabetes mellitus. The rising prevalence of type 2 diabetes has driven an increase in rates of CKD in the past 3 decades in the United States. In turn, so have the rates for complications related to type 2 diabetes including CKD, eg, diabetic kidney disease (DKD). Although incident rates for DKD have stab...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Acute Kidney Injury and Progression of Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Samuel Mon-Wei Yu, Joseph V. BonventreDiabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of DN includes glomerular basement membrane thickening, mesangial expansion, nodular glomerular sclerosis, and tubulointerstitial fibrosis. Diabetes is associated with a number of metabolic derangements, such as reactive oxygen species overproduction, hypoxic state, mitochondrial dysfunction, and inflammation. In the...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Inflammatory Mechanisms as New Biomarkers and Therapeutic Targets for Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Radica Z. Alicic, Emily J. Johnson, Katherine R. TuttleDiabetic kidney disease (DKD) is the leading cause of CKD and end-stage kidney disease (ESKD) worldwide. Approximately 30-40% of people with diabetes develop this microvascular complication, placing them at high risk of losing kidney function as well as of cardiovascular events, infections, and death. Current therapies are ineffective for arresting kidney disease progression and mitigating risks of comorbidities and death among patients with DKD. As the global count of ...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Role of Kidney Biopsies for Biomarker Discovery in Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Helen C. Looker, Michael Mauer, Robert G. NelsonAlthough estimated glomerular filtration rate and albuminuria are well-established biomarkers of diabetic kidney disease (DKD), additional biomarkers are needed, especially for the early stages of the disease when both albuminuria and estimated glomerular filtration rate may still be in the normal range and are less helpful for identifying those at risk of progression. Traditional biomarker studies for early DKD are challenging because of a lack of good early clinical end poin...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

The Promise of Systems Biology for Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Frank C. Brosius, Wenjun JuDiabetic kidney disease (DKD) has a complex and prolonged pathogenesis involving many cell types in the kidney as well as extrarenal factors. It is clinically silent for many years after the onset of diabetes and usually progresses over decades. Given this complexity, a comprehensive and unbiased molecular approach is best suited to help identify the most critical mechanisms responsible for progression of DKD and those most suited for targeted intervention. Systems biological investigations provid...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents for National Kidney Foundation 2018 Spring Clinical Meeting Abstracts April 10-14, 2018
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Implementation of a Program to Manage Transition of Care for End-Stage Renal Disease (ESRD) Patients Discharged from the Hospital
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Cardiovascular Risk Stratification Tool Evaluation in Renal Transplant Recipients
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Depression and Medication Adherence in Patients on Hemodialysis
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Transition from Pediatric to Adult Dialysis Care in an Adult with Special Considerations Due to Neurocognitive Aspects of Asperger Syndrome
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Peritoneal Dialysis in Octogenerians
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

QI Project to Increase Venipuncture Best Practice in Patients with GFR < 60mg/dl
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Quality of Life in Patients with Early Stage CKD After Mindful Eating Intervention to Improve Self-Management of Dietary Intake
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Masthead
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium: An Important Orphan
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium Homeostasis in CKD
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): David J. Leehey (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium Balance and Measurement
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Snigdha T. Reddy, Sandeep S. Soman, Jerry YeeMagnesium is an essential ion in the human body, playing an important role in practically every major metabolic and biochemical process, supporting and maintaining cellular processes critical for human life. Magnesium plays an important physiological role, particularly in the brain, heart, and skeletal muscles. As the second most abundant intracellular cation after potassium, it is involved in over 600 enzymatic reactions including energy metabolism and protein synthesis. Magnesium...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Dietary Magnesium and Chronic Disease
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Forrest H. NielsenAlthough official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement. This moderate or marginal (subclinical) deficient Mg intake generally is asymptomatic. Animal studies, however, indicate that moderate or subclinical Mg deficiency primes phagocytic cells for the release of proinflammatory cytokines leading to chronic inflammatory and oxidative stress. Human studies have found that dietary Mg ...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium Handling in the Kidney
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Joshua N. Curry, Alan S.L. YuMagnesium is a divalent cation that fills essential roles as regulator and cofactor in a variety of biological pathways, and maintenance of magnesium balance is vital to human health. The kidney, in concert with the intestine, has an important role in maintaining magnesium homeostasis. Although micropuncture and microperfusion studies in the mammalian nephron have shone a light on magnesium handling in the various nephron segments, much of what we know about the protein mediators of magnesium hand...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium and Blood Pressure: A Physiology-Based Approach
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Joëlle C. Schutten, Michel M. Joosten, Martin H. de Borst, Stephan J.L. BakkerHypertension is an important public health challenge because of its high prevalence and strong association with cardiovascular disease and premature death. Hypertension is a major cause of CKD, is present in more than 80% of CKD patients, and contributes to CKD progression. Risk factors for hypertension include, but are not limited to, age, race, family history, obesity, physical inactivity, tobacco use, and inadequate intake of minerals such a...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium and Cardiovascular Disease
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Kamonwan Tangvoraphonkchai, Andrew DavenportMagnesium is the most abundant intracellular divalent cation and essential for maintaining normal cellular physiology and metabolism, acting as a cofactor of numerous enzymes, regulating ion channels and energy generation. In the heart, magnesium plays a key role in modulating neuronal excitation, intracardiac conduction, and myocardial contraction by regulating a number of ion transporters, including potassium and calcium channels. Magnesium also has a role in regulating vascular t...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Oral Magnesium Supplementation and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial
The objective of the study was to evaluate the efficacy of oral magnesium supplementation in the improvement of metabolic syndrome (MetS) and its components. This is a randomized double-blind, placebo-controlled clinical trial that enrolled 198 individuals with MetS and hypomagnesemia who were randomly allocated to receive either 30 mL of magnesium chloride 5% solution, equivalent to 382 mg of elemental magnesium (n = 100), or placebo solution (n = 98), daily for 16 weeks. Serum magnesium levels
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium and Drugs Commonly Used in Chronic Kidney Disease
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Jeffrey H. William, Katelyn Richards, John DanzigerAs with other electrolytes, magnesium homeostasis depends on the balance between gastrointestinal absorption and kidney excretion. Certain drugs used commonly in patients with CKD can decrease gastrointestinal ingestion and kidney reclamation, and potentially cause hypomagnesemia. Other magnesium-containing drugs such as laxatives and cathartics can induce hypermagnesemia, particularly in those with impaired glomerular filtration and magnesium excretion. In this review, we wi...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium and Progression of Chronic Kidney Disease: Benefits Beyond Cardiovascular Protection?
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Yusuke Sakaguchi, Takayuki Hamano, Yoshitaka IsakaExperimental and clinical studies have demonstrated that magnesium deficiency leads to hypertension, insulin resistance, and endothelial dysfunction, and is associated with an increased risk of cardiovascular events. Given that cardiovascular disease and CKD share similar risk factors, the low magnesium status may also contribute to CKD progression. In fact, lower serum magnesium levels and lower dietary magnesium intake are associated with an increased risk of incident CKD an...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium as a Calcification Inhibitor
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Lucie Hénaut, Ziad A. MassyVascular calcification (VC) is associated with elevated cardiovascular mortality rates in patients with CKD. Recent clinical studies of patients with advanced CKD have observed an association between low serum magnesium (Mg) levels on one hand and elevated VC and cardiovascular mortality on the other. These findings have stimulated interest in understanding Mg's impact on CKD in general and the associated VC in particular. In vitro and preclinical in vivo data indicate that Mg has t...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Magnesium Balance in Chronic and End-Stage Kidney Disease
This article explores the effects of CKD and end-stage kidney disease on magnesium balance. In CKD, there is decreased glomerular filtration of magnesium. Decreased tubular reabsorption can compensate to a degree, but once CKD stage 4 is reached there is a tendency toward hypermagnesemia. In dialysis, magnesium balance is dependent on the constituents of the dialysate that the blood is exposed to. The concentration of dialysate magnesium is just one of the factors that need to be considered. During transplantation, there are particular effects of immunosuppressants that can affect the magnesium balance and need to be consi...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Renal Functional Reserve Revisited
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Ragnar Palsson, Sushrut S. WaikarKidney function, like the function of other organs, is dynamic and continuously adjusts to changes in the internal environment to maintain homeostasis. The glomerular filtration rate, which serves as the primary index of kidney function in clinical practice, increases in response to various physiological and pathological stressors including oral protein intake. The difference between the glomerular filtration rate in the resting state and at maximum capacity has been termed renal functional re...
Source: Advances in Chronic Kidney Disease - July 10, 2018 Category: Urology & Nephrology Source Type: research

Masthead
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Diabetes and the Kidney: Sweet Dreams
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): James E. Novak, Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Diabetic Kidney Disease (c. 2018)
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Katherine R. Tuttle (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

The Global Epidemiology of Diabetes and Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Digsu N. Koye, Dianna J. Magliano, Robert G. Nelson, Meda E. PavkovThe prevalence of diabetes is increasing worldwide, with the greatest increases occurring in low- and middle-income countries. In most developed countries, type 2 diabetes is presently the leading cause of end-stage renal disease and also contributes substantially to cardiovascular disease. In countries with weaker economies type 2 diabetes is rapidly replacing communicable diseases as a leading cause of kidney disease and is increasingly competing for scarc...
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Competing Risk of Death With End-Stage Renal Disease in Diabetic Kidney Disease
We present an example taken from the Action to Control Cardiovascular Risk in Diabetes, a randomized trial of people with type 2 diabetes at high risk for cardiovascular disease. Participants were stratified according to baseline markers of kidney disease: (1) no kidney disease; (2) low estimated glomerular filtration rate; (3) microalbuminuria alone; and (4) macroalbuminuria. The macroalbuminuria group had the highest risk for ESRD and demonstrated the most marked difference between the Kaplan-Meier and cumulative incidence estimator. Cox and Fine-Gray regression models yielded similar risk estimates for baseline characte...
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Glycemic Control as Primary Prevention for Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Richard J. MacIsaac, George Jerums, Elif I. EkinciImproving strategies to prevent the development and progression of CKD is a highly desirable outcome for all involved in the care of patients with diabetes. This is because CKD is a major factor contributing to morbidly and mortality in patients with diabetes. Furthermore, diabetes is the leading cause of ESRD in most developed countries. Although tight glucose control is now an established modality for preventing the development and progression of albuminuria, evidence is n...
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

New Glucose-Lowering Agents for Diabetic Kidney Disease
In conclusion, currently available trials have demonstrated renoprotective effects for certain glucagon-like peptide-1 receptor agonists, liraglutide and semaglutide, and the sodium-glucose cotransporter 2 inhibitors, empagliflozin and canagliflozin. Dipeptidyl peptidase-4 inhibitors did not show a significant renoprotective effect. Nevertheless, larger studies with respect to renoprotective effects of these 3 drug classes are currently being performed, and thus, no conclusions for all of these agents can yet be made. (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Treatment of Diabetic Kidney Disease With Hypertension Control and Renin Angiotensin System Inhibition
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Vikram Patney, Kunal Chaudhary, Adam Whaley-ConnellThe global incidence and prevalence of diabetes continues to expand due primarily to the influences of obesity and the contribution of obesity to the progression of type 2 diabetes mellitus. The rising prevalence of type 2 diabetes has driven an increase in rates of CKD in the past 3 decades in the United States. In turn, so have the rates for complications related to type 2 diabetes including CKD, eg, diabetic kidney disease (DKD). Although incident rates for DKD have stab...
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Acute Kidney Injury and Progression of Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Samuel Mon-Wei Yu, Joseph V. BonventreDiabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of DN includes glomerular basement membrane thickening, mesangial expansion, nodular glomerular sclerosis, and tubulointerstitial fibrosis. Diabetes is associated with a number of metabolic derangements, such as reactive oxygen species overproduction, hypoxic state, mitochondrial dysfunction, and inflammation. In the...
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research

Inflammatory Mechanisms as New Biomarkers and Therapeutic Targets for Diabetic Kidney Disease
Publication date: March 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 2Author(s): Radica Z. Alicic, Emily J. Johnson, Katherine R. TuttleDiabetic kidney disease (DKD) is the leading cause of CKD and end-stage kidney disease (ESKD) worldwide. Approximately 30-40% of people with diabetes develop this microvascular complication, placing them at high risk of losing kidney function as well as of cardiovascular events, infections, and death. Current therapies are ineffective for arresting kidney disease progression and mitigating risks of comorbidities and death among patients with DKD. As the global count of ...
Source: Advances in Chronic Kidney Disease - July 5, 2018 Category: Urology & Nephrology Source Type: research