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Total 108 results found since Jan 2013.

Electroacupuncture reverses endothelial cell death and promotes angiogenesis through the VEGF/Notch signaling pathway after focal cerebral ischemia ‐reperfusion injury
ConclusionOur findings showed that EA plays a role in promoting angiogenesis following focal CIRI, and we hypothesized that this was due to the regulation of ECs by the EA-activated VEGF/Notch signaling pathway.
Source: Brain and Behavior - February 14, 2023 Category: Neurology Authors: Wenyu Zhang, Lin Han, Yan Wen, Lixian Su, Yibing Li, Xudong Luo Tags: ORIGINAL ARTICLE Source Type: research

Electro-acupuncture treatment ameliorates intestinal inflammatory injury in cerebral ischemia-reperfusion rats via regulating the balance of Treg / γδ T cells
Brain Res. 2023 Jan 6:148233. doi: 10.1016/j.brainres.2023.148233. Online ahead of print.ABSTRACTElectro-acupuncture (EA) has an anti-inflammatory role in ischemic stroke, but whether the protective effect of EA involves the regulation of the intestine barrier and Treg/ γδ T cells is unclear. Cerebral ischemia-reperfusion (I/R) injury was induced by middle cerebral artery occlusion(MCAO) for 2 hours followed by reperfusion for 24 hours. The rats have treated with EA at the "Baihui" acupoint(GV20). Triphenyl tetrazolium chloride (TTC) staining and Longa neurologic score were performed to evaluate the outcomes after ischem...
Source: Brain Research - January 9, 2023 Category: Neurology Authors: Ya-Ling Wang Ling-Ling Meng Yong-Lin Chen Ling OuYang Bu-Fan Wu Rou Peng Sheng-Feng Lu Qing Liu Tao Zhang Xiao-Xiao Li Xin-Yue Jing Bin Xu Shu-Ping Fu Source Type: research

The combination of Astragalus membranaceus and ligustrazine mitigates cerebral ischemia ‐reperfusion injury via regulating NR2B‐ERK/CREB signaling
ConclusionsThe overall results thus suggest that the Ast+Lig combination conferred neuroprotective properties against cerebral I/R injury via regulation of the NR2B-ERK/CREB signaling pathway.
Source: Brain and Behavior - December 31, 2022 Category: Neurology Authors: Xialing Tang, Shanshan Xie, Huajun Wang, Yingbin Li, Zhiyu Lai, Shuangxi Sun, Ruanhuan Pan, Yan Huang, Jun Cai Tags: ORIGINAL ARTICLE Source Type: research

Neuroprotective effects of < em > Chrysanthemum morifolium < /em > on cerebral ischemia- reperfusion injury contributes to the oxidative stress suppression and related Keap1/Nrf2 pathway
CONCLUSION: CME could significantly reduce oxidative stress and nerve injury in vitro and in vivo models of CI/RI by regulating the Keap1/Nrf2 pathway.PMID:36567616 | DOI:10.1080/02699052.2022.2158225
Source: Brain Injury - December 26, 2022 Category: Neurology Authors: Zibin Zhang Xiaojun Pang Yuyu Wei Huai Chen Xuhong Jin Qingping Lv Source Type: research

Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke
AbstractDespite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that  ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDVLG3), a 21-kDa C-terminal subdomain of rhPDV, has been demonstrated to more avidly bind to the α2β1 integrin receptor than its parent molecule and consequently was postulated to evok...
Source: Translational Stroke Research - December 12, 2022 Category: Neurology Source Type: research

Effects of the New Thrombolytic Compound LT3001 on Acute Brain Tissue Damage After Focal Embolic Stroke in Rats
In this study, we tested the effects of LT3001 as a potential alternative thrombolytic in focal embolic ischemic stroke rat model. Stroked rats received intravenous injection of 10  mg/kg LT3001 or tPA at 1.5, 3, or 4.5 h after stroke, respectively, and the outcomes were measured at different time points after stroke by performing multi-parametric MRI, 2,3,5-triphenyltetrazolium chloride (TTC) staining, and modified neurological severity score. Lastly, we assessed the effect of LT3001 on the tPA activity in vitro, the international normalized ratio (INR), and the serum levels of active tPA and plasminogen activator inhib...
Source: Translational Stroke Research - November 29, 2022 Category: Neurology Source Type: research

Salidroside attenuates cerebral ischemia/reperfusion injury by regulating TSC2-induced autophagy
In conclusion, SAL reduces the inflammatory response and oxidative stress in a concentration-dependent manner, and protects against cerebral I/R injury by modulating TSC2-induced autophagy. These findings suggest SAL may prove to be a potential therapeutic agent for ischemic stroke.PMID:36374318 | DOI:10.1007/s00221-022-06493-6
Source: Brain Research - November 14, 2022 Category: Neurology Authors: Chunli Li Jiejun Chi Hongyan Dai Ming Liang Yangyang Wang Songxin Tian Huiyan Zhu Hai Xu Source Type: research

Protective Effect of Ergothioneine Against Stroke in Rodent Models
AbstractErgothioneine (ET) is a naturally occurring antioxidant and cytoprotective agent that is synthesized by fungi and certain bacteria. Recent studies have shown a beneficial effect of ET on neurological functions, including cognition and animal models of depression. The aim of this study is to elucidate a possible effect of ET in rodent models of stroke. Post-ischemic intracerebroventricular (i.c.v.) infusion of ET significantly reduced brain infarct volume by as early as 1  day after infusion in rats, as shown by triphenyltetrazolium chloride (TTC) assay. There was a dose-dependent increase in protection, from 50 to...
Source: NeuroMolecular Medicine - October 19, 2022 Category: Neurology Source Type: research

Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3
CONCLUSION: Altogether, circPRDX3 inhibited the development of IS by sponging miR-641, hence increasing NPR3 expression and inactivating MAPK pathway. These results may aid in the search of potential therapy targets for IS.PMID:36208650 | DOI:10.1016/j.brainres.2022.148114
Source: Brain Research - October 8, 2022 Category: Neurology Authors: Weiping Chen Yangbo Zhang Min Yin Zhijuan Cheng Dandan Li Xin Luo Xu Liu Jianglong Tu Source Type: research

Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model
We examined the effects of low-dose ALM on ischemic stroke in cell and animal models. Cobalt chloride (CoCl2) –treated SH-SY5Y cells were used as a surrogate model to mimic oxygen–glucose deprivation conditions. The cells were incubated with different dilutions of ALM authentic solution (1.0 mM adenosine, 2.0 mM lidocaine, and5 mM MgSO4 in Earle’s balanced salt solution). At a concentration of 2.5%, ALM significantly reduced CoCl2-induced cell loss. This protective effect persisted even when ALM was administered 1  h after the insult. We used transient middle cerebral artery occlusion to investigate the therapeuti...
Source: Molecular Neurobiology - October 1, 2022 Category: Neurology Source Type: research

GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner
AbstractNo current treatments target microvascular reperfusion after stroke, which can contribute to poor outcomes even after successful clot retrieval. The G protein –coupled receptor GPR39 is expressed in brain peri-capillary pericytes, and has been implicated in microvascular regulation, but its role in stroke is unknown. We tested the hypothesis that GPR39 plays a protective role after stroke, in part due to preservation of microvascular perfusion. We gener ated GPR39 knockout (KO) mice and tested whether GPR39 gene deletion worsens capillary blood flow and exacerbates brain injury and functional deficit after focal ...
Source: Translational Stroke Research - October 1, 2022 Category: Neurology Source Type: research

Chuanzhitongluo regulates microglia polarization and inflammatory response in acute ischemic stroke
CONCLUSIONS: These results indicate that CZTL alleviates neuroinflammation and brain damage after AIS in mice, which may be mediated by modulating microglia polarization.PMID:36152772 | DOI:10.1016/j.brainresbull.2022.09.015
Source: Brain Research Bulletin - September 24, 2022 Category: Neurology Authors: Qingqing Wang Bin Han Xu Man Huali Gu Jinping Sun Source Type: research