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Chuanzhitongluo regulates microglia polarization and inflammatory response in acute ischemic stroke
CONCLUSIONS: These results indicate that CZTL alleviates neuroinflammation and brain damage after AIS in mice, which may be mediated by modulating microglia polarization.PMID:36152772 | DOI:10.1016/j.brainresbull.2022.09.015
Source: Brain Research - September 24, 2022 Category: Neurology Authors: Qingqing Wang Bin Han Xu Man Huali Gu Jinping Sun Source Type: research

Three Dimensional-Arterial Spin Labeling Evaluation of Improved Cerebral Perfusion After Limb Remote Ischemic Preconditioning in a Rat Model of Focal Ischemic Stroke
ConclusionThree dimensional (3D) ASL can be used to evaluate LRP to improve stroke perfusion, and its protective effect may be closely related to LRP-induced vascular regeneration.
Source: Frontiers in Neuroanatomy - June 30, 2022 Category: Neurology Source Type: research

Early Hyperchloremia is Independently Associated with Death or Disability in Patients with Intracerebral Hemorrhage
ConclusionsThe independent association between hyperchloremia and death or disability at 90  days suggests that avoidance of hyperchloremia may reduce the observed death or disability in patients with ICH.Clinical Trial RegistrationClinicalTrials.gov: NCT01176565.
Source: Neurocritical Care - May 5, 2022 Category: Neurology Source Type: research

Beta-Boswellic Acid Protects Against Cerebral Ischemia/Reperfusion Injury via the Protein Kinase C Epsilon/Nuclear Factor Erythroid 2-like 2/Heme Oxygenase-1 Pathway
This study demonstrates that β-BA exerts neuroprotective effects against cerebral I/R via the activation of the PRKCE/NFE2L2/HMOX1 pathway and is a potentia l therapeutic candidate for ischemic stroke.Graphical abstract
Source: Molecular Neurobiology - May 3, 2022 Category: Neurology Source Type: research

An Optimal Animal Model of Ischemic Stroke Established by Digital Subtraction Angiography-Guided Autologous Thrombi in Cynomolgus Monkeys
ConclusionOur study may provide an optimal non-human primate model for an in-depth study of the pathogenesis and treatment of focal cerebral ischemia.
Source: Frontiers in Neurology - April 25, 2022 Category: Neurology Source Type: research

Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period
CONCLUSION: Lithium upregulates BDNF, GAP-43, and PSD-95, which partly accounts for its improvement of neuroplasticity and provision of long-term neuroprotection in the ischemic brain.Abbreviations: BDNF: brain-derived neurotrophic factor; ECM: extracellular matrix; EDTA: ethylenediaminetetraacetic acid; GAP-43: growth-associated protein-43; GSK-3β: glycogen synthase kinase-3β; HBSS: Hank's balanced salt solution; LCBF: local cortical blood perfusion; LDF: laser-Doppler flowmetry; MCAO: middle cerebral artery occlusion; MMP: matrix metalloproteinase; NMDA: N-methyl-D-aspartate; NMDAR: N-methyl-D-aspartate receptor; OCT: ...
Source: Neurological Research - March 29, 2022 Category: Neurology Authors: Shih-Huang Tai Sheng-Yang Huang Liang-Chun Chao Yu-Wen Lin Chien-Chih Huang Tian-Shung Wu Yan-Shen Shan Ai-Hua Lee E-Jian Lee Source Type: research

Evaluation of anti-inflammatory diphenyldihaloketone EF24 in transient ischemic stroke model
CONCLUSIONS: EF24 controls infarct growth and suppresses tissue inflammation in ischemic stroke, which can be monitored by 18F-FGA uptake.PMID:35254869 | DOI:10.1080/02699052.2022.2034959
Source: Brain Injury - March 7, 2022 Category: Neurology Authors: Alexander Mdzinarishvili Hailey Houson Andria Hedrick Vibhudutta Awasthi Source Type: research

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