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Total 1078 results found since Jan 2013.
Treatment of ischemic stroke with modified mesenchymal stem cells
Int J Med Sci. 2022 Jun 27;19(7):1155-1162. doi: 10.7150/ijms.74161. eCollection 2022.ABSTRACTIschemic stroke is one of the leading causes of death and disability. Ischemia triggers a cascade of events leading to cell death and cerebral infarction. Mesenchymal stem cell (MSC) therapy is a promising treatment modality to promote the development of nerve and blood vessels and improve nerve function. However, MSCs have a limited therapeutic effect in the harsh microenvironment of ischemic brain tissue. Modified MSC therapy shows better therapeutic effect under different pathological conditions, and is expected to be translate...
Source: International Journal of Medical Sciences - August 3, 2022 Category: Biomedical Science Authors: Hao Chen Liangfu Zhou Source Type: research
Preconditioning exercise reduces hippocampal neuronal damage via increasing Klotho expression in ischemic rats
In this study, we assessed neuroprotective effects of preconditioning exercise in rats (treadmill running at a speed of 20m/min,30min/day, six days/week, for3 weeks) on hippocampal Klotho and MnSOD expression in the brain using an animal model of stroke, middle cerebral artery occlusion (MCAO). Our study revealed a reduction in hippocampal Klotho and MnSOD expression as well as CA1 neuronal activity in MCAO compared to the sham group. Exercise prevented the ischemia-induced decline in Klotho and MnSOD expression levels as well as CA1 neuronal activity in Exercise + MCAO compared to the MCAO group. Also, exercise significan...
Source: Brain Research Bulletin - August 2, 2022 Category: Neurology Authors: Maryam Soleimani Karizmeh Maryam Shabani Mostafa Shabani Maryam Sardari Javad Fahanik Babaei Fatemeh Nabavizadeh Seyed Shahabeddin Sadr Soheila Adeli Source Type: research
Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB
Appl Biochem Biotechnol. 2022 Jul 15. doi: 10.1007/s12010-022-04060-x. Online ahead of print.ABSTRACTCerebral ischemia and successive reperfusion are the prevailing cause of cerebral stroke. Currently cerebral stroke is considered to be one of the prior causes for high mortality, disability, and morbidity. Cynaropicrin, a sesquiterpene lactone, exhibits various pharmacologic properties and also has an anti-inflammatory property associated with the suppression of the key pro-inflammatory NF-κB pathway. The protective effect of cynaropicrin against oxidative stress and neuroinflammation during CIR injury through the modulat...
Source: Applied Biochemistry and Biotechnology - July 15, 2022 Category: Biochemistry Authors: Tao Jin Bing Leng Source Type: research
Anti-apoptosis effects of codonolactone on cerebral ischemia-reperfusion injury
This study investigated the roles of codonolactone in inflammation, oxidative stress and apoptosis after cerebral ischemia-reperfusion (I/R) injury. Rats with codonolactone treatment, I/R treatment and the sham operation group were used in this study. After reperfusion for 24 hours, nerve damage was detected by nerve staining, and the neurological deficits of the rats were analyzed. The contents of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in rat brain tissues were also determined. Western blot analysis was performed to determine the ...
Source: Journal of Investigative Medicine - June 22, 2022 Category: Research Authors: Chen, F., Lin, W. Tags: Original research Source Type: research
The Bioactivities of Phycocyanobilin from Spirulina
J Immunol Res. 2022 Jun 11;2022:4008991. doi: 10.1155/2022/4008991. eCollection 2022.ABSTRACTPhycocyanobilin (PCB) is a linear open-chain tetrapyrrole chromophore that captures and senses light and a variety of biological activities, such as anti-oxidation, anti-cancer, and anti-inflammatory. In this paper, the biological activities of PCB are reviewed, and the related mechanism of PCB and its latest application in disease treatment are introduced. PCB can resist oxidation by scavenging free radicals, inhibiting the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and delaying the activity of antiox...
Source: Atherosclerosis - June 21, 2022 Category: Cardiology Authors: Yi Li Source Type: research
