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Nutrition: Antidoxidants
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Total 1078 results found since Jan 2013.
Edaravone, a scavenger for multiple reactive oxygen species, reacts with singlet oxygen to yield 2-oxo-3-(phenylhydrazono)-butanoic acid
In this study, we investigated the reactivity of edaravone toward 1O2 and identified its reaction products. Edaravone showed a reactivity toward 1O2 greater than those of uric acid, histidine, and tryptophan, which are believed to be 1O2 scavengers in vivo. And we confirmed that 2-oxo-3-(phenylhydrazono)-butanoic acid was formed as an oxidation product. We propose a plausible mechanism for 2-oxo-3-(phenylhydrazono)-butanoic acid production by 1O2-induced edaravone oxidation. Since 2-oxo-3-(phenylhydrazono)-butanoic acid has already been identified as a radical-initiated oxidation product, free radical-induced oxidati...
Source: Journal of Clinical Biochemistry and Nutrition - June 13, 2022 Category: Nutrition Authors: Sakiko Amekura Kyouhei Shiozawa Chihiro Kiryu Yorihiro Yamamoto Akio Fujisawa Source Type: research
The role of glutathione peroxidase-1 in health and disease
Free Radic Biol Med. 2022 Jun 9:S0891-5849(22)00224-6. doi: 10.1016/j.freeradbiomed.2022.06.004. Online ahead of print.ABSTRACTGlutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it has a single redox-sensitive selenocysteine amino acid that is important for the enzymatic reduction of hydrogen peroxide and soluble lipid hydroperoxides. Glutathione provides the source of reducing equivalents for its function. As an antioxidant enzyme, GPx1 modulates the balance between necessary and harmful levels of reactive...
Source: Free Radical Biology and Medicine - June 12, 2022 Category: Biology Authors: Diane E Handy Joseph Loscalzo Source Type: research
Evening Primrose Extracts Inhibit PDGF-BB-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Regulating Cell-Cycle-Related Proteins
In conclusion, the results demonstrate that EVP inhibited PDGF-BB-induced VSMC proliferation and migration by regulating cell-cycle-related proteins.PMID:35678660 | DOI:10.3390/cimb44050131
Source: Mol Biol Cell - June 9, 2022 Category: Molecular Biology Authors: Jin-Ho Lee Min Jeong Kim Keun-Jung Woo Joonpyo Hong Sun-Hong Kim Tack-Joong Kim Source Type: research
