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Nutrition: Calcium
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Total 1776 results found since Jan 2013.
Repurposing the KCa3.1 Blocker Senicapoc for Ischemic Stroke
AbstractSenicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC50 of 7 nM, reduced Ca2+ signaling induced by the purinergic agonist ATP, suppressed express...
Source: Translational Stroke Research - April 24, 2023 Category: Neurology Source Type: research
Neural circuit changes in neurological disorders: Evidence from in vivo two-photon imaging
Ageing Res Rev. 2023 Apr 13;87:101933. doi: 10.1016/j.arr.2023.101933. Online ahead of print.ABSTRACTNeural circuits, such as synaptic plasticity and neural activity, are critical components of healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing procedure affecting neuronal activities. Disruption of this essential process results in diseases. Advanced microscopic applications such as two-photon laser scanning microscopy have recently been applied to understand neural circuit changes during disease since it can visualize fine structural and functional cellular activation in living anim...
Source: Ageing Research Reviews - April 15, 2023 Category: Genetics & Stem Cells Authors: Huan Xiong Fei Tang Yujie Guo Ruxiang Xu Peng Lei Source Type: research
Neural Circuit Changes in Neurological Disorders: Evidence from in vivo Two-photon Imaging
Ageing Res Rev. 2023 Apr 13:101933. doi: 10.1016/j.arr.2023.101933. Online ahead of print.ABSTRACTNeural circuits, such as synaptic plasticity and neural activity, are critical components of healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing procedure affecting neuronal activities. Disruption of this essential process results in diseases. Advanced microscopic applications such as two-photon laser scanning microscopy have recently been applied to understand neural circuit changes during disease since it can visualize fine structural and functional cellular activation in living animals...
Source: Ageing Research Reviews - April 15, 2023 Category: Genetics & Stem Cells Authors: Huan Xiong Fei Tang Yujie Guo Ruxiang Xu Peng Lei Source Type: research
Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease
ConclusionThe frequency of coronary calcification was higher in subjects with stroke caused by large-artery atherosclerosis than in controls.
Source: Frontiers in Neurology - April 12, 2023 Category: Neurology Source Type: research
The association of calcium channel blocker with risk of adverse limb events in patients with chronic limb-threatening ischemia after endovascular treatment
This study highlights the necessity of future studies regarding CCB.Clinical Trial Registration: URL:https://www.umin.ac.jp; Unique identifiers: UMIN000015100.
Source: Cardiovascular Intervention and Therapeutics - April 3, 2023 Category: Cardiology Source Type: research
Design and synthesis of novel GluN2A NMDAR positive allosteric modulators via scaffold hopping strategy as anti-stroke therapeutic agents
This study reported a series of GluN1/2A positive allosteric modulators as neuroprotective agents, and provided a potential opportunity to discover new drugs for stroke treatment.PMID:36934527 | DOI:10.1016/j.bmc.2023.117236
Source: Bioorganic and Medicinal Chemistry - March 19, 2023 Category: Chemistry Authors: Xin Chen Hongyu Zhu Xuequan Liu Qihong Li Mingxin Dong Source Type: research
Association of Beta Blockers and Calcium Channel Blockers with Arrhythmia After Carotid Intervention
Postoperative arrhythmia has a reported incidence of 2% to 4%, which can increase patients ’ risk of developing stroke or myocardial infarction; however, insufficient data are available regarding the prognostic implications and management of arrhythmia after carotid intervention. The aim of this study was to identify the factors associated with arrhythmia after carotid intervention usin g data collected as a part of the Society for Vascular Surgery Vascular Quality Initiative.
Source: Journal of Vascular Surgery - March 17, 2023 Category: Surgery Authors: Teah Qvavadze, Fedor Lurie, Todd Russell Source Type: research
Repair of traumatic lesions to the plasmalemma of neurons and other cells: Commonalities, conflicts, and controversies
We describe current research gaps and potential future developments, such as much more extensive correlations of biochemical/biophysical measures with sub-cellular micromorphology. We compare and contrast naturally occurring sealing with recently-discovered artificially-induced plasmalemmal sealing by polyethylene glycol (PEG) that bypasses all natural pathways for membrane repair. We assess other recent developments such as adaptive membrane responses in neighboring cells following injury to an adjacent cell. Finally, we speculate how a better understanding of the mechanisms involved in natural and artificial plasmalemmal...
Source: Frontiers in Physiology - March 15, 2023 Category: Physiology Source Type: research
Icariin protects cerebral neural cells from ischemia ‑reperfusion injury in an < em > in vitro < /em > model by lowering ROS production and intracellular calcium concentration
Exp Ther Med. 2023 Feb 16;25(4):151. doi: 10.3892/etm.2023.11849. eCollection 2023 Apr.ABSTRACTIschemia is one of the major causes of stroke. The present study investigated the protection of cultured neural cells by icariin (ICA) against ischemia-reperfusion (I/R) injury and possible mechanisms underlying the protection. Neural cells were isolated from neonatal rats and cultured in vitro. The cells were subjected to oxygen-glucose deprivation and reoxygenation (OGD-R) as an I/R mimic to generate I/R injury, and were post-OGD-R treated with ICA. Following the treatments, cell viability, apoptosis, reactive oxygen species (R...
Source: Experimental and Therapeutic Medicine - March 13, 2023 Category: General Medicine Authors: Ke Ning Rong Gao Source Type: research
