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Total 615 results found since Jan 2013.
Exploring the Recent Trends in Management of Dementia and Frailty: Focus on Diagnosis and Treatment
Curr Med Chem. 2022 Apr 8. doi: 10.2174/0929867329666220408102051. Online ahead of print.ABSTRACTDementia and frailty increase health adversities in older adults, which are topics of growing research interest. Frailty is considered to correspond to a biological syndrome associated with age. Frail patients may ultimately develop multiple dysfunctions across several systems, including stroke, transient ischemic attack, vascular dementia, Parkinson's disease, Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, cortico-basal degeneration, multiple system atrophy, amyotrophic lateral sclerosis, and Creutzfe...
Source: Current Medicinal Chemistry - April 11, 2022 Category: Chemistry Authors: Md Mominur Rahman Sadia Afsana Mim Md Rezaul Islam Anwar Parvez Fahadul Islam Mohammad Borhan Uddin Md Saidur Rahaman Pollob Ahmed Shuvo Muniruddin Ahmed Nigel H Greig Mohammad Amjad Kamal Source Type: research
Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1
In this study, the neuroprotective effect of Guhong injection (GHI) on middle cerebral artery occlusion (MCAO)-induced reperfusion injury was assessed and the mechanism was explored by RNA-seq technology. GHI administered for 6 consecutive days significantly decreased body weight loss, infarction rate, neurological deficient scores, and neuron loss but improved rat survival percentage and regional cerebral blood flow after MCAO surgery. Furthermore, we identified inflammation as a vital process and C5AR1 as a vital target in GHI-mediated protection by using RNA-seq analysis. Further experiments confirmed that GHI decreased...
Source: Frontiers in Pharmacology - March 21, 2022 Category: Drugs & Pharmacology Source Type: research
Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy
Biosci Rep. 2022 Mar 31;42(3):BSR20212209. doi: 10.1042/BSR20212209.ABSTRACTDiabetes mellitus is a chronic metabolic disease that occurs when the pancreas is not producing enough insulin or when the insulin that it does produce is not able to be used effectively in the body. This results in hyperglycemia and if the blood sugars are not controlled, then it can lead to serious damage of various body systems, especially the nerves and the blood vessels. Uncontrolled diabetes is a major cause of kidney failure, heart attacks, stroke and amputation. One of the most devastating complications for patients is diabetic retinopathy ...
Source: Bioscience Reports - March 2, 2022 Category: Biomedical Science Authors: Jennifer Matthews Lakshini Herat Jennifer Rooney Elizabeth Rakoczy Markus Schlaich Vance B Matthews Source Type: research
The effect of obesity, hypertension, diabetes mellitus, alcohol, and sleep apnea on the risk of atrial fibrillation
Physiol Res. 2021 Dec 30;70(Suppl4):S511-S525.ABSTRACTAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia associated with a two-fold increase in mortality caused by a higher risk of stroke and heart failure. Currently, AF is present in ~ 2 % of the general population, and its incidence and prevalence are increasing. Obesity, hypertension, diabetes mellitus, obstructive sleep apnea, and alcohol consumption increase the risk of AF. Each unit of increase in BMI increases the risk of AF by 3 %, and intensive weight loss is also associated with reduced AF recurrence. Hypertension increases the risk of AF by...
Source: Physiological Research - February 24, 2022 Category: Physiology Authors: Z Čarná P Osman čík Source Type: research
Validity of the Controlling Nutritional Status score as a Nutritional Assessment Tool early after stroke
This study investigated the prognostic role of malnutrition, as assessed by the CONUT scoring system. We hypothesized that malnutrition negatively affects outcomes as expressed by Functional Independence Measure (FIM) motor or Berg Balance Scale (BBS) change in stroke patients. This was a retrospective cohort study involving 117 individuals including first-time subacute stroke inpatients from March 2017 to February 2020. All participants were evaluated with BBS and FIM. We used multiple linear regression analysis with backward stepwise selection to examine the association between CONUT and changes during rehabilitation. Af...
Source: International Journal of Rehabilitation Research - February 10, 2022 Category: Rehabilitation Tags: Original articles Source Type: research
Prevalence of Complications Associated with Diabetes among Pakistani Patients: A Questionnaire-Based Survey
CONCLUSION: All age groups showed diabetes-associated complications and different abnormal body conditions. However, the age groups ranging from thirty to eighty years showed more complications. The most prevalent complications reported were retinopathy, nephropathy, diabetic wounds on the foot, slow wound healing, seizures, hypertension, neuropathy, skin infections, cardiovascular disorders, liver damage and stroke in both types of diabetic patients. Our survey may aid in pointing out the most prevalent diabetic complications prevailing in our population so that effective treatment options could be developed to reduce the...
Source: Current Diabetes Reviews - January 19, 2022 Category: Endocrinology Authors: Sana Eijaz Sarah Lalpuria Mahrukh Afzal Ariba Yasmeen Sadia Saleem Asma Begum Source Type: research
