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Total 615 results found since Jan 2013.
Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Mol Cell Biochem. 2023 Jan 7. doi: 10.1007/s11010-022-04653-4. Online ahead of print.ABSTRACTStroke cachexia is associated with prolonged inflammation, muscle loss, poor prognosis, and early death of stroke patients. No particular treatment is available to cure the symptoms or disease. The present study aimed to evaluate the effect of a 5-HT1a agonist, buspirone on stroke cachexia. Wistar rats were injected with endothelin-1 to the bregma region of the brain to induce ischemic stroke followed by induction of cachexia after 4 days. Treatment with buspirone (3 mg/kg p.o) was given for 4 weeks after confirmation of cachexia i...
Source: Molecular and Cellular Biochemistry - January 7, 2023 Category: Biochemistry Authors: Darshak Shah Mit Joshi Jigna Shah Bhoomika M Patel Source Type: research
Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke
AbstractDespite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDVLG3), a 21-kDa C-terminal subdomain of rhPDV, has been demonstrated to more avidly bind to the α2β1 integrin receptor than its parent molecule and consequently was postulated to evok...
Source: Translational Stroke Research - December 12, 2022 Category: Neurology Source Type: research
Preoperative risk model for perioperative stroke after intracranial tumor resection: ACS NSQIP analysis of 30,951 cases
CONCLUSIONS: The current study proposes a novel preoperative risk model for PCVA in patients undergoing ITR. Patients with poor physiological reserve (measured by frailty), multiple comorbidities, abnormal preoperative laboratory values, and those admitted under high acuity were at highest risk. The ITR-PCVA risk model may support patient-centered counseling striving to respect goals of care and maximize quality of life. Future prospective studies are warranted to validate the ITR-PCVA risk model and evaluate its utility as a bedside clinical tool.PMID:36455279 | DOI:10.3171/2022.9.FOCUS22402
Source: Neurosurgical Focus - December 1, 2022 Category: Neurosurgery Authors: Alexander J Kassicieh Kavelin Rumalla Syed Faraz Kazim Derek B Asserson Meic H Schmidt Christian A Bowers Source Type: research
Disturbed Sleep is Not Good for the Heart: A Narrative Review
Curr Cardiol Rev. 2022 Nov 30. doi: 10.2174/1573403X19666221130100141. Online ahead of print.ABSTRACTSleep-related breathing disorders, including obstructive sleep apnea (OSA) and central sleep apnea (CSA), have a major impact on cardiovascular function. It has shown an association with hypertension, coronary artery disease, cardiac arrhythmias, sudden cardiac death, and congestive heart failure (CHF). This review focuses on highlighting the relationship between sleep apnea and CHF. We discuss the underlying pathophysiology which involves the mechanical, neurohormonal, and inflammatory mechanisms; in addition, the similari...
Source: Current Cardiology Reviews - December 1, 2022 Category: Cardiology Authors: Meet Patel Harshani Yarlagadda Shubekshya Upadhyay Ritesh Neupane Umer Qureshi Joseph D Raco Rahul Jain Rohit Jain Source Type: research
Preoperative risk model for perioperative stroke after intracranial tumor resection: ACS NSQIP analysis of 30,951 cases
CONCLUSIONS: The current study proposes a novel preoperative risk model for PCVA in patients undergoing ITR. Patients with poor physiological reserve (measured by frailty), multiple comorbidities, abnormal preoperative laboratory values, and those admitted under high acuity were at highest risk. The ITR-PCVA risk model may support patient-centered counseling striving to respect goals of care and maximize quality of life. Future prospective studies are warranted to validate the ITR-PCVA risk model and evaluate its utility as a bedside clinical tool.PMID:36455279 | DOI:10.3171/2022.9.FOCUS22402
Source: Neurosurgical Focus - December 1, 2022 Category: Neurosurgery Authors: Alexander J Kassicieh Kavelin Rumalla Syed Faraz Kazim Derek B Asserson Meic H Schmidt Christian A Bowers Source Type: research
EE675 Cost-Utility Analysis of Metabolic Surgery Compared With Best Medical Care for the Treatment of Comorbid Type 2 Diabetes and Obesity
Type 2 diabetes (T2D) is associated with an increased risk of many serious health complications including stroke, kidney disease and blindness. Weight-loss is an important part of T2D management and can lead to improvements in cardiometabolic risk factors and an associated decreased risk of T2D-related complications. The aim of this cost-utility analysis was to estimate the cost-effectiveness of metabolic surgery compared with best medical care (BMC) for the treatment of comorbid T2D and obesity.
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: K Jordan, C Teljeur, B Clyne, P Harrington, M Ryan Source Type: research
Better Together: Evolution of Patient Stakeholder Engagement in Healthy Lifestyle Research After Acquired Brain Injury
To describe the process of partnering with stakeholders in a six-year systematic line of research to modify an evidence-based weight-loss program called the Diabetes Prevention Program Group Lifestyle Balance (DPP-GLB) for individuals with individuals with TBI and stroke. Commentary from two patient stakeholders will be included.
Source: Archives of Physical Medicine and Rehabilitation - December 1, 2022 Category: Rehabilitation Authors: Evan McShan, Audrey Self, Emily Nalepa, Simon Driver Tags: Research Poster 2184389 Source Type: research
Transitioning to GLP-1 RAs and SGLT2 Inhibitors as the First Choice for Managing Cardiometabolic Risk in Type 2 Diabetes
Abstract Purpose of ReviewThis forward-looking review summarizes existing evidence from cardiovascular outcome trials on cardiometabolic risk-reduction in type 2 diabetes (T2DM) management, with attention to updating and personalizing recommendations from recent diabetes practice guidelines issued by cardiology societies.Recent FindingsT2DM management has shifted towards cardiometabolic outcome improvement rather than purely glycemic control. According to large clinical trials, sodium-glucose cotransporter-2 inhibitors showed robust results in reducing heart failure (HF) hospitalization and chronic kidney disease (CKD) p...
Source: Current Atherosclerosis Reports - November 24, 2022 Category: Cardiology Source Type: research
How People With Diabetes Can Lower Stroke Risk
After spending nearly two decades trying to manage her Type 2 diabetes, Agnes Czuchlewski landed in the emergency room in 2015, with news that she’d just experienced a heart attack. She also learned that she had metabolic syndrome, a cluster of conditions that includes diabetes but also brings higher risk of heart disease and stroke.
“Because I needed to lose quite a bit of weight when I was first diagnosed, I was focused on the number I saw on the scale, and then on my blood-sugar numbers,” recalls Czuchlewski, 68, who lives in New York City. “I didn’t realize other numbers came into play, li...
Source: TIME: Health - November 10, 2022 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized Disease healthscienceclimate Source Type: news
Effects of Exercise Mode on Improving Cardiovascular Function and Cardiorespiratory Fitness After Bariatric Surgery: A Narrative Review
Obesity affects 600 million people globally and increases the risk of developing cardiovascular disease, stroke, diabetes, and cancer. Bariatric surgery is an increasingly popular therapeutic intervention for morbid obesity to induce rapid weight loss and reduce obesity-related comorbidities. However, some bariatric surgery patients, after what is considered a successful surgical procedure, continue to manifest obesity-related health issues, including weight gain, reduced physical function, persistent elevations in blood pressure, and reduced cardiorespiratory fitness. Cardiorespiratory fitness is a strong predictor of mor...
Source: American Journal of Physical Medicine and Rehabilitation - October 29, 2022 Category: Rehabilitation Tags: Literature Reviews Source Type: research
