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Total 130 results found since Jan 2013.

IP117. Perioperative Complication Risk Prediction According to Carotid Plaque Ulceration in 964 Consecutive Carotid Endarterectomies ∗
The role of the carotid plaque fibrous cap in carotid-related stroke risk has been demonstrated in many studies. The aim of this study was to evaluate the relationship between the presence of a carotid plaque ulcer and the perioperative complication risk in a consecutive series/cohort of patients submitted to carotid endarterectomy (CEA) at our academic tertiary hospital.
Source: Journal of Vascular Surgery - May 22, 2018 Category: Surgery Authors: Laura Capoccia, Pasqualino Sirignano, Wassim Mansour, Maria Antonietta Panico, Martina Formiconi, Virgilio Baldassarre, Enrico Sbarigia, Francesco Speziale Source Type: research

Does Hospital Volume Affect Outcomes in Patients Undergoing Vestibular Schwannoma Surgery?
Objective: To determine the effect of hospital surgical case volume on the outcomes of vestibular schwannoma surgery. Study Design: Retrospective case review. Setting: University HealthSystem Consortium member hospitals (includes nearly every US academic medical center). Patients: Three thousand six hundred ninety-seven patients who underwent vestibular schwannoma resection over a 3-year timespan (2012–2015) grouped by race, age, comorbidities, payer, and sex. Intervention: Surgical resection of vestibular schwannoma. Main Outcome Measures: Morbidity and mortality following vestibular schwannoma excision...
Source: Otology and Neurotology - March 29, 2018 Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research

Ischemic Stroke Profile, Risk Factors, and Outcomes in India Brief Report
Background and Purpose—The Indo-US Collaborative Stroke Project was designed to characterize ischemic stroke across 5 high-volume academic tertiary hospitals in India.Methods—From January 2012 to August 2014, research coordinators and physician coinvestigators prospectively collected data on 2066 patients with ischemic stroke admitted
Source: Stroke - December 22, 2017 Category: Neurology Authors: P.N. Sylaja, Jeyaraj Durai Pandian, Subhash Kaul, M.V. Padma Srivastava, Dheeraj Khurana, Lee H. Schwamm, Praveen Kesav, Deepti Arora, Aman Pannu, Tijy K. Thankachan, Aneesh B. Singhal Tags: Ischemic Stroke Brief Reports Source Type: research

Redivus Health Launches State of Kansas Initiative in Partnership With The University of Kansas Health System
OLATHE, Kan. & KANSAS CITY, Kan. (Dec. 11, 2017) — Redivus Health announced today it will partner with The University of Kansas Health System to roll out the Redivus mobile clinical decision support platform to Kansas hospitals and Emergency Medical Services (EMS) providers starting this month. The initiative builds on a pilot program started earlier this year. “The goal of the Kansas Heart and Stroke Collaborative is to improve the care and outcomes of rural Kansans with heart attacks and strokes. Our rural health system partners helped develop the protocols and tools to implement evidenced-based guidelines,” sa...
Source: JEMS Administration and Leadership - December 11, 2017 Category: Emergency Medicine Authors: Revidus Health Tags: Administration and Leadership Industry News Source Type: news

Prophylactic Anticonvulsants in Intracerebral Hemorrhage
DiscussionLevetiracetam was routinely prescribed following ICH and was not associated with worse outcomes. Future investigations should examine the effect of prophylactic levetiracetam on cost and neuropsychological outcomes as well as the role of continuous EEG in identifying subclinical seizures.
Source: Neurocritical Care - October 1, 2017 Category: Neurology Source Type: research

Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial
This study is registered with ClinicalTrials.gov, number NCT01959451, and EudraCT, 2013-001636-22. Findings Between Dec 2, 2013, and May 20, 2016, 2610 patients were assigned to study groups; 1304 to the guided de-escalation group and 1306 to the control group. The primary endpoint occurred in 95 patients (7%) in the guided de-escalation group and in 118 patients (9%) in the control group (pnon-inferiority=0·0004; hazard ratio [HR] 0·81 [95% CI 0·62–1·06], psuperiority=0·12). Despite early de-escalation, there was no increase in the combined risk of cardiovascular death, myocardial infarction, or stroke in the de-es...
Source: The Lancet - August 29, 2017 Category: General Medicine Source Type: research

FDA approves pivotal study of Vascular Dynamics MobiusHD high blood pressure device
Vascular Dynamics said today that the FDA approved an investigational device exemption for a clinical trial of its MobiusHD device for treating resistant hypertension. MobiusHD is designed to help regulate blood pressure using electrodes implanted in the carotid artery to stimulate baroreceptors there. Mountain View, Calif.–based Vascular Dynamics said the 300-patient Calm 2 study is designed to compare treatment with MobiusHD and a sham procedure. The primary safety endpoint is a composite of death, myocardial infarction, stroke, device embolization, carotid occlusion, new ipsilateral carotid stenosis requiring surgic...
Source: Mass Device - August 15, 2017 Category: Medical Devices Authors: Brad Perriello Tags: Cardiovascular Clinical Trials Food & Drug Administration (FDA) Regulatory/Compliance vasculardynamics Source Type: news

Saving Vanessa, part 1: A mystery rash, a stroke and an epic rescue
Vanessa’s rash first appeared on her arms and legs when she 3 or 4 months old. It was red and bumpy and went away when she was sick with a virus, which happened often. Then it would come back. The dermatology team she saw at Boston Children’s Hospital was puzzled. “I was expecting they were going to think it was nothing, but they took it very seriously,” says Katherine Bell, one of Vanessa’s mothers. “They took a biopsy and very quickly realized they had no idea what it was.” Vanessa’s case was even featured at a regional dermatology conference where doctors take up mystery patients. “A hundred to 150 der...
Source: Thrive, Children's Hospital Boston - July 25, 2017 Category: Pediatrics Authors: Nancy Fliesler Tags: Diseases & Conditions Our Patients’ Stories Dr. Carolyn Rogers Dr. Pui Lee Dr. Robert Sundel Dr. Scellig Stone Dr. Todd Lyons stroke Source Type: news

Secondary attention-deficit/hyperactivity disorder following perinatal and childhood stroke: impact on cognitive and academic outcomes.
Abstract This cross-sectional retrospective clinical research study examines a large group of children followed within a pediatric stroke program and a developmental attention-deficit/hyperactivity disorder (ADHD) clinic at the Hospital for Sick Children, between May 2004 and June 2016. All children with a history of stroke who participated in a neuropsychological assessment between the ages of 4 and 18 years were considered for inclusion. From a sample of 275 participants with a history of stroke, 36 children (13.1%) received a diagnosis of secondary ADHD. Children with secondary ADHD were younger at the time of...
Source: Child Neuropsychology - May 30, 2017 Category: Child Development Authors: Williams TS, Roberts SD, Coppens AM, Crosbie J, Dlamini N, Westmacott R Tags: Child Neuropsychol Source Type: research

Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study
This study is registered with ClinicalTrials.gov, number NCT01052480. Findings Between Jan 13, 2011, and March 2, 2015, 113 participants were screened for eligibility and 98 were randomly assigned from 20 out of 29 participating sites. Of the participants with confirmed influenza (by PCR), 28 (67%) of 42 in the plasma plus standard care group normalised their respiratory status by day 28 compared with 24 (53%) of 45 participants on standard care alone (p=0·069). The hazard ratio (HR) comparing plasma plus standard care with standard care alone was 1·71 (95% CI 0·96–3·06). Six participants died, one (2%) from the plas...
Source: The Lancet Respiratory Medicine - May 16, 2017 Category: Respiratory Medicine Source Type: research

Vascular closure devices in stroke patients receiving tissue plasminogen activator: A retrospective analysis from an academic tertiary medical center and a teaching community hospital stroke database
Stroke is the fourth leading cause of death in the United States [1]. Recanalization, or opening, of the blocked artery in ischemic stroke patients can limit the extent of infarction and significantly improve a patient's outcome [2]. In 1995, NINDS tPA (tissue plasminogen activator) trial suggested that tPA administered intravenously within three hours of stroke onset could improve functional outcomes in patients [3]. Since then, acute stroke therapy has been in constant evolution with the universal goals of improving outcomes and reduction in complications.
Source: Clinical Neurology and Neurosurgery - March 29, 2017 Category: Neurosurgery Authors: Mangaladevi S. Patil, Mahesh V. Jayaraman, Sun H. Ahn Source Type: research

Utilizing CT with Maximum Intensity Projection Reconstruction Bypassing CTA Improves Time to Groin Puncture in Large Vessel Occlusion Stroke Thrombectomy
Background and Purpose: Prior to thrombectomy for proximal anterior circulation large vessel occlusion (LVO) stroke, recent trials have utilized CT angiography (CTA) for vascular imaging immediately following noncontrast CT (NCCT) for decision-making, but thin-section NCCT with automated maximum intensity projection (MIP) reconstruction also has high accuracy in demonstrating the site of an occluding thrombus. We hypothesized that performing thin-section NCCT with MIP alone prior to thrombectomy improves the time to groin puncture (GP) compared to performing CTA after NCCT.Materials and Methods: We performed a retrospectiv...
Source: Interventional Neurology - March 28, 2017 Category: Neurology Source Type: research

Getting Social in the Real World
Although it would be facetious to say that social media has reached a tipping point into ubiquity, it is only relatively recently that it has been used by pharma to collect and analyze patient data. This use of social media may only be in its infancy but as a quick and inexpensive way to gather large-scale, real-world data it is growing rapidly.Technology always outstrips the glacial pace that industry moves at, but this ‘sudden’ move creates a sharp learning curve for many pharma companies. Issues around regulation and resources will hinder some, while others will fail to see the value of ‘social health’.Popular s...
Source: EyeForPharma - March 6, 2017 Category: Pharmaceuticals Authors: Danielle Barron Source Type: news