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Total 854 results found since Jan 2013.

The Effects of Balloon Occlusion of the Aorta on Cerebral Blood Flow, Intracranial Pressure, and Brain Tissue Oxygen Tension in a Rodent Model of Penetrating Ballistic-Like Brain Injury
Trauma is among the leading causes of death in the United States. Technological advancements have led to the development of resuscitative endovascular balloon occlusion of the aorta (REBOA) which offers a pre-hospital option to non-compressible hemorrhage control. Due to the prevalence of concomitant traumatic brain injury (TBI), an understanding of the effects of REBOA on cerebral physiology is critical. To further this understanding, we employed a rat model of penetrating ballistic-like brain injury (PBBI). PBBI produced an injury pattern within the right frontal cortex and striatum that replicates the pathology from a p...
Source: Frontiers in Neurology - December 17, 2019 Category: Neurology Source Type: research

Influence of a Comorbid Diagnosis of Seizure on 30-Day Readmission Rates Following Hospitalization for an Index Stroke
Objective: To examine the association of a comorbid seizure diagnosis with early hospital readmission rates following an index hospitalization for stroke in the United States. Methods: Retrospective analysis of the 2014 National Readmission Database. The study population included adult patients (age>18 years old) with stroke, identified using the International Classification of Disease Ninth Revision, Clinical Modification (ICD-9-CM) codes 433.X1, 434.X1, and 436 for ischemic stroke as well as 430, 431, 432.0, 432.1, and 432.9 for hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2019 Category: Neurology Authors: Alain Lekoubou, Kinfe G Bishu, Bruce Ovbiagele Source Type: research

A Blood Filter Fights Deadly Inflammatory Response
A new blood filtration technology may prove to be life-saving for patients whose normally healthy inflammatory response to injury or illness has gone into overdrive, resulting in fatally high levels of cytokines in their blood. In an interview with MD+DI, Dr. Phillip Chan, MD, PhD, CEO of CytoSorbents Corp., explained that inflammation, and the production of substances called cytokines that drive inflammation, are the body’s natural response to heal injury or infection. But sometimes, the inflammatory response is so severe in such conditions as sepsis and infection, burn injuries, trauma, pancreatitis, li...
Source: MDDI - October 9, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Cardiovascular Source Type: news

Dog Ownership Linked To 24% Lower Risk Of Dying Early, Research Shows
(CNN) — Need an excellent reason to add a dog to your life? How about living longer? “Our analysis found having a dog is actually protective against dying of any cause,” said Mount Sinai endocrinologist Dr. Caroline Kramer, lead author of a new systematic review of nearly 70 years of global research published Tuesday in “Circulation,” a journal of the American Heart Association. The review of the health benefits of man’s best friend analyzed research involving nearly 4 million people in the United States, Canada, Scandinavia, New Zealand, Australia and the United Kingdom. “Dog owne...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 8, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Featured Health News Offbeat Syndicated CBSN Boston CNN Dogs Source Type: news

Causes of Acute Stroke: A Patterned Approach.
This article reviews the imaging patterns of acute strokes, and how the infarct pattern and imaging characteristics can suggest an underlying cause. PMID: 31582037 [PubMed - in process]
Source: Radiologic Clinics of North America - October 5, 2019 Category: Radiology Authors: Knight-Greenfield A, Nario JJQ, Gupta A Tags: Radiol Clin North Am Source Type: research

Causes of Acute Stroke
This article reviews the imaging patterns of acute strokes, and how the infarct pattern and imaging characteristics can suggest an underlying cause.
Source: Radiologic Clinics of North America - October 1, 2019 Category: Radiology Authors: Ashley Knight-Greenfield, Joel Jose Quitlong Nario, Ajay Gupta Source Type: research

Incidence and Causes of In-hospital Outcomes and 30-day Readmissions After Percutaneous Left Atrial Appendage Closure: A United States Nationwide Retrospective Cohort Study Using Claims Data
Percutaneous left atrial appendage closure (p-LAAC) emerged as an option for stroke prevention in atrial fibrillation (AF) patients ’ ineligible for long-term anticoagulation.Real-world data on its in-hospital and 30-day readmission measures are limited.
Source: Heart Rhythm - September 16, 2019 Category: Cardiology Authors: Venkat L.K. Vuddanda, Mohit K. Turagam, Nikita A. Umale, Zubair Shah, Dhanunjaya R. Lakkireddy, Krzysztof Bartus, Finnian R. McCausland, Poonam Velagapudi, Moussa Mansour, E. Kevin Heist Source Type: research

Letter to the Editor Regarding “Relationship of Malnutrition during Hospitalization with Functional Recovery and Postdischarge Destination in Elderly Stroke Patients”
We read with great interest the article by Sato et al on the relationship of malnutrition with acute stroke in 205 patients hospitalized at the Shinshu University hospital, Japan.1 We would like to provide an additional nationwide United States (US) perspective on outcomes of hospitalized stroke patients with protein energy malnutrition (PEM).
Source: Journal of Stroke and Cerebrovascular Diseases - September 2, 2019 Category: Neurology Authors: Rupak Desai, Alok R. Amraotkar Tags: Letter to the Editor Source Type: research

Atrial Septal Defect and the Risk of Ischemic Stroke in the Perioperative Period of Noncardiac Surgery
Stroke is a serious complication of non-cardiac surgery. Congenital defects of the interatrial septum may be a potent risk factor for perioperative stroke. The aim of the present study was to determine the association between atrial septal defect (ASD) or patent foramen ovale (PFO) and in-hospital perioperative ischemic stroke after non-cardiac surgery in a large nationwide cohort of patients hospitalized in the United States. Patients undergoing noncardiac surgery between 2004 and 2014 were identified using the Healthcare Cost and Utilization Project's National Inpatient Sample.
Source: The American Journal of Cardiology - July 14, 2019 Category: Cardiology Authors: Nathaniel R. Smilowitz, Varun Subashchandran, Jeffrey S. Berger Source Type: research

National Performance on the Medicare SEP-1 Sepsis Quality Measure
We examined the hospital factors associated with reporting SEP-1 data, the hospital factors associated with performance on the SEP-1 measure, and the relationship between SEP-1 performance and performance on other quality measures related to time-sensitive medical conditions. A total of 3,283 hospitals were eligible for the analysis, of which 2,851 (86.8%) reported SEP-1 performance data. SEP-1 reporting was more common in larger, nonprofit hospitals. The most common reason for nonreporting was an inadequate case volume. Among hospitals reporting SEP-1 performance data, overall bundle compliance was generally low, but it v...
Source: Critical Care Medicine - July 13, 2019 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Integration of Real-Time Electronic Health Records and Wireless Technology in a Mobile Stroke Unit
Background: UCHealth's Mobile Stroke Unit (MSU) at University of Colorado Hospital is an ambulance equipped with a computed tomography (CT) scanner and tele-stroke capabilities that began clinical operation in Aurora, Colorado January 2016. As one of the first MSU's in the United States, it was necessary to design unique and dynamic information technology infrastructure. This includes high-speed cellular connectivity, Health Insurance Portability and Accountability Act compliance, cloud-based and remote access to electronic medical records (EMR), and reliable and rapid image transfer.
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2019 Category: Neurology Authors: Brandi Schimpf, Kathy Deanda, David A. Severenuk, Tara M. Montgomery, Gregory D. Cooley, Robert G. Kowalski, Daniel Vela-Duarte, William J. Jones Source Type: research

Embolic stroke of undetermined source (ESUS) cohort of Brazilian patients in a university hospital
ABSTRACT Embolic stroke of undetermined source (ESUS) is an important group of cryptogenic strokes that are in evidence due recent ongoing trials. We reviewed medical records at discharge from the stroke unit of all patients who met ESUS criteria and attended our institution between February 2016 and July 2017. Among 550 stroke patients, 51 had ESUS. We found that hypertension (60%), diabetes mellitus (34%), and smoking (36%) were the most prevalent risk factors. The mean National Institutes of Health Stroke Scale (NIHSS) scores were 7 at admission and 4 at discharge, while median scores on the modified Rankin scale were 0...
Source: Arquivos de Neuro-Psiquiatria - June 10, 2019 Category: Neurology Source Type: research

Pre-existing Renal Failure Increases In-Hospital Mortality in Patients With Intracerebral Hemorrhage
We read with interest the study of Khatri et al that concluded pre-existing renal failure increased the risk of in-hospital mortality among patients with intracerebral hemorrhage (ICH).1 These results were derived from a retrospective analysis of over 328,000 adult patients (11.8% with pre-existing renal failure) who were admitted to hospitals in the United States with ICH over a 5-year period.
Source: Journal of Stroke and Cerebrovascular Diseases - May 22, 2019 Category: Neurology Authors: Ruemon Bhattacharyya, Larry E. Miller Tags: Letter to the Editor Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Got...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research