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Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi ’an Stroke Registry Study of China
In this study, we aimed to investigate the relationship between...
Source: BMC Geriatrics - July 5, 2023 Category: Geriatrics Authors: Zhongzhong Liu, Xuemei Lin, Lingxia Zeng, Huan Zhang, Weiyan Guo, Qingli Lu, Congli Huang, Jing Wang, Pei Liu, Qiaoqiao Chang, Mi Zhang, Yan Huo, Yan Wang, Fang Wang and Songdi Wu Tags: Research Source Type: research

Challenges of implementation of the RCPCH paediatric stroke guidelines (acute management component) and how they can be overcome
In August 2017, the Royal College of Paediatric and Child Health (RCPCH) published guidelines for the management of stroke in childhood between 1 month and 18 years of age (see hyperlink). This comprehensive 169-page publication is a National Institute for Health and Care Excellence (NICE)-accredited multiprofessional evidence-based guideline that provides recommendations for the management of stroke in children and young people. A small proportion of the guideline focuses on acute ischaemic stroke management with thrombolysis. Only a small number of children will be eligible for consideration for thrombolysis; however, it...
Source: Archives of Disease in Childhood - June 17, 2022 Category: Pediatrics Authors: Byrne, S., Ram, D. Tags: Review Source Type: research

Non-ischemic cerebral enhancing lesions after thrombectomy: a multicentric retrospective French national registry
This study provides evidence that NICE lesions following MT are a possible rare complication with a similar pr esentation as previously described following endovascular aneurysm treatment. Both radiologists and neurologists should be aware of this adverse event and make use of MRI contrast agents in case of unexplained symptoms/images during follow-up after MT.
Source: Neuroradiology - April 12, 2022 Category: Radiology Source Type: research

A journey through clinic and research
I started to study Medicine at the University of Genoa, Italy more than 20 years ago and I now realize that I was quite far from understanding what ‘Medicine’ really means. After weeks and weeks spent on books during the first year, I understood that becoming a MD not only requires the willingness to help people with health problems, but also strong motivation and dedication to learn a huge amount of notions. In Italy, as it is the case for several other countries, the University courses last 6 years, during which the MD student is fully engaged by individual study, lessons and seminars, exercises, and internships. Wit...
Source: European Heart Journal - March 29, 2021 Category: Cardiology Source Type: research

How You Should Spend That Extra Hour As Daylight Saving Time Ends
(CNN) — It’s Sunday morning, and you open your eyes to discover it’s still incredibly early because — huzzah! — we’ve reached the end of the seasonal practice known as Daylight Saving Time. Do you: A) Immediately roll over and go back to sleep? or B) Tell yourself that you shouldn’t be lazy, and get up to make the most of this “extra” hour? It’s a trick question, because there isn’t a perfectly right answer that would be the same for everyone. But in general, experts say, most should use the fall time change to squeeze in more sleep — and with zero gu...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 31, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Offbeat CNN Daylight saving time Source Type: news

Short-Term Outcomes After Off-Pump or On-Pump Coronary Artery Bypass Grafting in the Octogenarian Patients
Despite large randomized controlled trials demonstrating similar outcomes for of-pump or on-pump coronary artery bypass grafting, the debate between proponents of each technique remains current.1 On-pump technique improves surgical exposure on a nonbeating heart but exposes the patient to a powerful inflammatory response and to ischemic stroke owing to cross clamping and cannulation. Off-pump coronary artery bypass (OPCAB) may reduce blood transfusion, postoperative length of hospital stay, postoperative neurocognitive decline, and systemic anticoagulation, but heart repositioning may be associated with hemodynamic instabi...
Source: Journal of Cardiothoracic and Vascular Anesthesia - May 2, 2019 Category: Anesthesiology Authors: B érénice Tiquet, Jean David Blossier, Isabelle Orsel, Frank Pihan, Alessandro Piccardo, Jean Phillippe Marsaud, David Vandroux Tags: Letter to the Editor Source Type: research

Reply: Septic cerebral emboli as a risk factor for thrombolysis-related haemorrhagic transformation
We appreciate the opportunity to respond to Dr. Jolobe ’s letter titled ‘Septic cerebral emboli as a risk factor for thrombolysis-related hemorrhagic transformation’. Dr. Jolobe made a nice comment on our article titled ‘Risk factors of hemorrhagic transformation after intravenous thrombolysis with rt-PA in acute cerebral infarction’.1 We agree that septic cerebral emboli was a risk factor for thrombolysis-related hemorrhagic transformation as demonstrated in an early study.2 In fact, it was based on this early study and the following studies that intravenous thrombolysis is not recommended for patients with acut...
Source: QJM - January 25, 2019 Category: Internal Medicine Source Type: research

Thrombectomy to be offered up to 24h after onset of stroke
NICE recommends procedure in new draft guideline Related items fromOnMedica Stroke survivors need more help taking medicine Stroke deaths falling in Europe, overall Diagnosing a transient ischaemic attack One in two women and one in three men will develop neurological disease Having a stroke doubles dementia risk
Source: OnMedica Latest News - November 26, 2018 Category: UK Health Source Type: news

Basilar artery occlusion with “seizures” as a presenting symptom: three cases treated using mechanical thrombectomy
We present 3 cases of patients with BAO presenting with seizures.
Source: World Neurosurgery - June 7, 2018 Category: Neurosurgery Authors: Ryosuke Otsuji, Junji Uno, Ryota Motoie, Satoshi Karashima, Nice Ren, Shintaro Nagaoka, Maeda Kazushi, Yoshiaki Ikai, Hidefuku Gi Tags: Case Report Source Type: research

108appropriate anticoagulation in older adults with atrial fibrillation
Introduction: Anticoagulation is recommended to prevent stroke in atrial fibrillation. NICE Guidelines state anticoagulation should be offered to all patients with a CHADVASC of 2 and above. The ESC (European Society of Cardiology) guidelines advise falls and advanced dementia should not prevent patients from receiving anticoagulation. Furthermore, advanced age (above 75 or 80 years old) should not mean anticoagulation is withheld, especially as the risk of ischaemic stroke increases with age and comorbidities.
Source: Age and Ageing - March 27, 2018 Category: Geriatrics Source Type: research

A Business Case For Stroke Reduction Initiatives In Atrial Fibrillation: 3-Year Financial Projections For Three UK Regions
Atrial Fibrillation (AF) is a common and treatable risk factor for ischaemic stroke and vascular dementia with rising incidence. Oral anticoagulation (OAC) therapy is a well-evidenced way to prevent AF-related strokes, as supported by NICE Clinical Guidelines (CG180, 2014).
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: A Orlowski, T Jamieson, J Belsey, R Slater, J Macdonald Source Type: research

Prognostic factors for patients with acute ischemic stroke treated by mechanical thrombectomy
【Background and Purpose】To elucidate the prognostic factors for mechanical thrombectomy (MT), we investigated (retrospectively) a series of patients with acute ischemic stroke (AIS) treated with MT in our hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Katsuharu Kameda, Junji Uno, Shota Yoshida, Ryosuke Otsuji, Nice Ren, Shintaro Nagaoka, Kazushi Maeda, Yoshiaki Ikai, Hidefuku Gi Source Type: research

NICE recommends treatment with alteplase is started as early as possible, within 4.5 hours of onset of ischaemic stroke symptoms
Source: Boehringer Ingelheim Corporate News - July 25, 2016 Category: Research Source Type: news

Rivaroxaban for Preventing Atherothrombotic Events in People with Acute Coronary Syndrome and Elevated Cardiac Biomarkers: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
Abstract As part of its Single Technology Appraisal process, the National Institute for Health and Care Excellence (NICE) invited the company that manufactures rivaroxaban (Xarelto, Bayer) to submit evidence of the clinical and cost effectiveness of rivaroxaban for the prevention of adverse outcomes in patients after the acute management of acute coronary syndrome (ACS). The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a critical review of the evidence for the clinical and cos...
Source: PharmacoEconomics - December 21, 2015 Category: Health Management Source Type: research

Correspondence The future of stroke therapy must not be mired by past arguments
Stroke is the leading cause of disability and the fifth leading cause of death in the UK, costing the UK economy more than £7 billion per year.1 At present, the only therapeutic approved by the UK National Institute for Health and Care Excellence (NICE) for the treatment of ischaemic stroke is thrombolysis using recombinant tissue-type plasminogen activator (rtPA). However, rtPA is only effective in patients who present within 4·5 h of stroke onset, with a number needed to treat for benefit of 3·6 before 90 min, rising to 5·9 between 3 h and 4·5 h.
Source: LANCET - August 14, 2015 Category: Journals (General) Authors: Alastair M Buchan, Hasneen G Karbalai, Brad A Sutherland Tags: Correspondence Source Type: research

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