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Condition: Stroke
Infectious Disease: Adenoviruses
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Total 114 results found since Jan 2013.
Molecular and pathological characterization of natural co-infection of poultry farms with the recently emerged Leucocytozoon caulleryi and chicken anemia virus in Egypt
AbstractIn the summers of 2018 and 2019, a disease outbreak stroke 25 broiler chicken farms and 3 broiler breeder farms in different Governorates in Egypt. The disease caused a mortality rate ranging from 3.2 to 9%. Postmortem examination showed petechial hemorrhage in the breast and thigh muscles, thymus gland, and peritoneal cavity and extensive hemorrhages in the kidneys. A total of 140 liver, kidney, lung, skeletal muscles, thymus, and spleen samples were collected. Twenty-eight pooled samples were created and examined by PCR and histopathological examination to identify the causative pathogens. All collected samples w...
Source: Tropical Animal Health and Production - February 8, 2022 Category: Veterinary Research Source Type: research
Ablation of Plasma Prekallikrein Decreases LDL Cholesterol by Stabilizing LDL Receptor and Protects against Atherosclerosis
Conclusions: PK regulates circulating cholesterol levels through binding to LDLR and inducing its lysosomal degradation. Ablation of PK stabilizes LDLR, decreases LDL cholesterol and prevents atherosclerotic plaque development. This study suggests that PK is a promising therapeutic target to treat ASCVD.PMID:35189703 | DOI:10.1161/CIRCULATIONAHA.121.056491
Source: Atherosclerosis - February 22, 2022 Category: Cardiology Authors: Jin-Kai Wang Yang Li Xiao-Lu Zhao Yuan-Bin Liu Jing Tan Yu-Ying Xing Dilare Adi Yong-Tao Wang Zhen-Yan Fu Yi-Tong Ma Song-Mei Liu Yong Liu Yan Wang Xiong-Jie Shi Xiao-Yi Lu Bao-Liang Song Jie Luo Source Type: research
UCHL1 protects against ischemic heart injury via activating HIF-1 α signal pathway
Redox Biol. 2022 Mar 18;52:102295. doi: 10.1016/j.redox.2022.102295. Online ahead of print.ABSTRACTUbiquitin carboxyl-terminal esterase L1 (UCHL1) has been thought to be a neuron specific protein and shown to play critical roles in Parkinson's Disease and stroke via de-ubiquiting and stabilizing key pathological proteins, such as α-synuclein. In the present study, we found that UCHL1 was significantly increased in both mouse and human cardiomyocytes following myocardial infarction (MI). When LDN-57444, a pharmacological inhibitor of UCHL1, was used to treat mice subjected to MI surgery, we found that administration of LDN...
Source: Cancer Control - March 27, 2022 Category: Cancer & Oncology Authors: Bingchuan Geng Xiaoliang Wang Ki Ho Park Kyung Eun Lee Jongsoo Kim Peng Chen Xinyu Zhou Tao Tan Chunlin Yang Xunchang Zou Paul M Janssen Lei Cao Lei Ye Xuejun Wang Chuanxi Cai Hua Zhu Source Type: research
Po-626-03 preclinical safety of adkcnh2-g628s for post-op af
Post-operative atrial fibrillation (POAF) occurs in 30% of cardiac surgeries, increasing risk of stroke, MI, and death. We propose gene therapy with an adenovirus encoding the G628S mutation of KCNH2 (AdKCNH2-G628S) to prevent POAF. We have reported preclinical efficacy in pigs.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: J. Kevin Donahue, David D. McManus Source Type: research
Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R3405.ABSTRACTThe choroid plexus (CP) is a small tissue located inside brain ventricles. It is responsible for the production of most of the cerebrospinal fluid (CSF); approximately 500 mL of CSF per day in the adult human [1, 2]. CSF production occurs as a net result of transcellular movement of salt and water, carried out by various cellular transporters. Ncbe is a sodium-coupled bicarbonate transporter located in the basolateral membrane of the choroid plexus epithelial (CPE) cells. It transports Na+ and HCO3 - into the cell in exchange for Cl- . Ncbe is the m...
Source: Pharmacological Reviews - May 13, 2022 Category: Drugs & Pharmacology Authors: Laura Ø Johnsen Kathrine A Friis Laura B Ry ø Jacob G Mikkelsen Thomas B Lindhardt Rasmus W Knopper Brian Hansen Jeppe Praetorius Helle H Damkier Source Type: research
Neuropathology of Pediatric SARS-CoV-2 Infection in the Forensic Setting: Novel Application of Ex Vivo Imaging in Analysis of Brain Microvasculature
We report 8 such cases (4 infants aged 7–36 weeks, 4 children aged 5–15 years). Four underwent ex vivo magnetic resonance neuroimaging, to assist in identification of subtle lesions related to vascular compromise. All infants were found unresponsive (3 in unsafe sleeping conditions); all but 1 had recent rhinitis and/or influenza-like illness (ILI) in the family; 1 had history of sickle cell disease. Ex vivo neuroimaging in 1 case revealed white matter (WM) signal hyperintensity and diffuse exaggeration of perivascular spaces, corresponding microscopically to WM mineralization. Neurohistology in the remaining 3 infants...
Source: Frontiers in Neurology - May 24, 2022 Category: Neurology Source Type: research
KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA
CONCLUSIONS: Our findings confirmed that simulated p-KAP1(S824) improved the survival and proliferation of endogenous NSCs. The underlying mechanism is that highly expressed p-KAP1(S824) promotes binding to PCNA, and inhibits the binding of CUL4A to PCNA. This reduced CUL4A-mediated ubiquitination degradation to increase the stability of PCNA and promote the survival and proliferation of NSCs.PMID:35799276 | DOI:10.1186/s13287-022-02962-5
Source: Cell Research - July 7, 2022 Category: Cytology Authors: Wan Wang Tianqing Yan Xinjian Guo Heng Cai Chang Liang Linyan Huang Yanling Wang Ping Ma Suhua Qi Source Type: research
Lipid Lowering Therapy: An Era Beyond Statins
Curr Probl Cardiol. 2022 Jul 30:101342. doi: 10.1016/j.cpcardiol.2022.101342. Online ahead of print.ABSTRACTDyslipidemia, specifically elevated LDL cholesterol levels, causes atherosclerotic cardiovascular disease (ASCVD) and increases the risk of myocardial infarction and stroke. Statins, a class of drugs that exert their effects by inhibiting HMG-CoA reductase, a key enzyme in the synthesis of cholesterol, have been the mainstay of therapy for the primary prevention of cardiovascular disease and lipids reduction. Statins are associated with side effects, most commonly myopathy and myalgias, despite their proven efficacy....
Source: Atherosclerosis - August 2, 2022 Category: Cardiology Authors: Toufik Abdul-Rahman Syed Muhammad Awais Bukhari Emiliano Cantu Herrera Wireko Andrew Awuah Jannel Lawrence Heloisa de Andrade Neal Patel Rohan Shah Raheel Shaikh Camilo Andr és Avendaño Capriles Sebahat Ulusan Shahzaib Ahmad Anna Corriero Adriana C Mare Source Type: research
