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Parkinsonism associated with viral infection
We present possible risk factors, proposed pathophysiology mechanisms, published case reports, common associations, and prognosis in order to offer a concise overview of the viral spectrum involved in parkinsonism.PMID:36208896 | DOI:10.1016/bs.irn.2022.07.005
Source: Herpes - October 8, 2022 Category: Infectious Diseases Authors: Irina Ivan Laura Irincu Ştefania Diaconu Cristian Falup-Pecurariu Source Type: research

Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies
In conclusion, this review has concisely summarized the current rare adverse events related and unrelated to BNT162b2, arguably for the first time in sufficient depth, to better communicate vaccine safety to the public.PMID:35891231 | DOI:10.3390/vaccines10071067
Source: Herpes - July 27, 2022 Category: Infectious Diseases Authors: Shin-Jie Yong Alice Halim Michael Halim Abbas Al Mutair Saad Alhumaid Jehad Al-Sihati Hawra Albayat Mohammed Alsaeed Mohammed Garout Reyouf Al Azmi Noor Aldakheel Abeer N Alshukairi Hani A Al Ali Adel A Almoumen Ali A Rabaan Source Type: research

Comparative Safety of BNT162b2 and mRNA-1273 Vaccines in a Nationwide Cohort of US Veterans
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that there were few differences in risk of adverse events within 14 days of the first dose of either the BNT162b2 or the mRNA-1273 vaccine and small-magnitude differences within 42 days of the first dose. The 38-week risks of adverse events were low in both vaccine groups, although risks were lower for recipients of the mRNA-1273 vaccine than for recipients of the BNT162b2 vaccine. Although the primary analysis was designed to detect safety events unrelated to SARS-CoV-2 infection, the possibility that these differences may partially be explained by a low...
Source: Herpes - June 13, 2022 Category: Infectious Diseases Authors: Barbra A Dickerman Arin L Madenci Hanna Gerlovin Katherine E Kurgansky Jessica K Wise Michael J Figueroa Mu ñiz Brian R Ferolito David R Gagnon J Michael Gaziano Kelly Cho Juan P Casas Miguel A Hern án Source Type: research

Delirium severity in critical patients with COVID-19 from an Infectious Disease Intensive Care Unit
SARS-CoV-2 causes potentially serious respiratory, gastrointestinal, neurologic and/or liver disorders. The prevalence of neurologic complications associated with SARS-CoV-2 infection varies according to the different studies, with the most common manifestations being headache, anosmia, and ageusia (Andreia  Costa, 2020). Other complications include stroke, epilepsy, neuromuscular symptoms, and delirium (Mao et al., 2020; Zubair et al., 2020).
Source: International Journal of Infectious Diseases - February 19, 2022 Category: Infectious Diseases Authors: Rafael Dias, Jo ão Paulo Caldas, André Silva-Pinto, Andreia Costa, António Sarmento, Lurdes Santos Source Type: research

Neurologic aspects of coronavirus disease of 2019 infection
Purpose of review Central and peripheral nervous system manifestations of coronavirus disease 2019 (COVID-19) have been frequently reported and may cause significant morbidity and mortality. This review details the latest evidence on the neuropathogenesis and neurologic complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent findings Commonly reported neurologic complications include toxic-metabolic encephalopathy, acute cerebrovascular disorders, seizures, and anoxic-brain injury. These complications represent secondary injury due to COVID-19 related hypoxia, sepsis, hype...
Source: Current Opinion in Infectious Diseases - May 2, 2021 Category: Infectious Diseases Tags: CNS INFECTIONS: Edited by Adarsh Bhimraj Source Type: research

Pneumonia in older adults
Purpose of review The purpose of this review is to address the relevant issues surrounding older adults with community-acquired pneumonia (CAP) today. Recent findings Approximately 1 million people>65 years have CAP in the US per year, which is more than previously reported (or realized). Older adults are vulnerable to the increasing prevalence of viral CAP, as the SARS-CoV-2 pandemic emphasizes, but pneumococcus is still the most common pathogen to cause CAP. Racial disparities continue to need to be addressed in order to improve early and late outcomes of older adults with CAP. Summary The epidemiolog...
Source: Current Opinion in Infectious Diseases - March 11, 2021 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

COVID-19 and Neurology - An Emerging Association
CONCLUSIONS: Presentation of COVID-19 with neurological features is not uncommon, and these patients should be tested earlier to help in the prevention of transmission, early diagnosis, and management.PMID:33602080 | DOI:10.2174/1871526521666210218202226
Source: Infectious Disorders Drug Targets - February 19, 2021 Category: Infectious Diseases Authors: Amit Gupta Prakrati Yadav Deepak Kumar Source Type: research

COVID-19 and Neurology - An Emerging Association.
CONCLUSIONS: Presentation of COVID-19 with neurological features is not uncommon, and these patients should be tested earlier to help in the prevention of transmission, early diagnosis, and management. PMID: 33602080 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - February 18, 2021 Category: Infectious Diseases Authors: Gupta A, Yadav P, Kumar D Tags: Infect Disord Drug Targets Source Type: research

NIH study uncovers blood vessel damage & inflammation in COVID-19 patients' brains but no infection
(NIH/National Institute of Neurological Disorders and Stroke) In an in-depth study of how COVID-19 affects a patient's brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after contracting the disease. In addition, they saw no signs of SARS-CoV-2 in the tissue samples, suggesting the damage was not caused by a direct viral attack on the brain.
Source: EurekAlert! - Infectious and Emerging Diseases - December 30, 2020 Category: Infectious Diseases Source Type: news

Acute ischemic and hemorrhagic stroke in two covid-19 patients.
We report two cases with coincident presentation of COVID-19 and cerebrovascular accident. Further studies are needed for a comprehensive understanding of the neurological pathology of COVID-19 and its effects on the nervous system, but stroke teams should be wary of the fact that COVID-19 patients can present with cerebrovascular accidents. PMID: 33132298 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - October 30, 2020 Category: Infectious Diseases Authors: Urciuoli L, Guerriero E, Musto L Tags: Jpn J Infect Dis Source Type: research

Excess mortality due to COVID-19 in Germany
SARS-CoV-2 is transmitted by droplets and likely aerosols. The median incubation period is about 5-6 days (range 1-14 days)1 and the median age at confirmed infection in Germany is 49 years. Typical symptoms include fever, cough, anosmia, ageusia, and pneumonia. The mortality rate of COVID-19 is higher among elderly and among ethnicities other than Caucasians. Furthermore, a markedly higher mortality rate has been observed for several comorbidities including obesity class II (BMI 35 •0-39•9 kg/m2) and III (BMI 40•0+ kg/m2), uncontrolled diabetes mellitus, malignancies in the previous year, severely reduced glomerular...
Source: Journal of Infection - September 17, 2020 Category: Infectious Diseases Authors: Andreas Stang, Fabian Standl, Bernd Kowall, Bastian Brune, Juliane B öttcher, Marcus Brinkmann, Ulf Dittmer, Karl-Heinz Jöckel Source Type: research

Neurologic aspects of covid-19: a concise review.
In conclusion, nervous system symptoms can be observed during SARS-CoV2 infection of which headache and smell and taste disturbance are the main symptoms reported. Cerebrovascular complications can complicate the course of COVID-19 in apparently low-risk patients. GBS is a life-threatening manifestation of COVID-19. PMID: 32532937 [PubMed - as supplied by publisher]
Source: Infezioni in Medicina - June 14, 2020 Category: Infectious Diseases Tags: Infez Med Source Type: research

COVID-19 patients may have lower stroke rates than previously suggested
(NYU Langone Health / NYU School of Medicine) Fewer people than previously reported suffer from stroke as a result of COVID-19, a new analysis finds. However, strokes that accompany the pandemic virus, SARS-CoV-2, appear to be more severe.
Source: EurekAlert! - Infectious and Emerging Diseases - May 20, 2020 Category: Infectious Diseases Source Type: news

COVID-19 related strokes, other neurological impact under study
(Medical College of Georgia at Augusta University) Traditional stroke treatments like clot-dissolving tPA and surgical removal of big clots in the brain are good choices as well when the stroke results from SARS-CoV-2 infection, investigators report.
Source: EurekAlert! - Infectious and Emerging Diseases - May 20, 2020 Category: Infectious Diseases Source Type: news

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