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Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)
Elife. 2023 Mar 22;12:e86002. doi: 10.7554/eLife.86002.ABSTRACTCOVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional malaise, and cognitive dysfunction that last for months and impact everyday functioning, is referred to as Long COVID under the general category of post-acute sequelae of SARS-CoV-2 infection (PASC). PASC is highly heterogenous and may be associated with multisystem tissue damage/dysfunction including acute encephalitis, cardiopulmonary syndromes, fibrosis, hepatobiliary damages, gastrointestinal dysregulation, myocardial infarction, neuromuscular syndromes, neuropsychiatric di...
Source: Herpes - March 22, 2023 Category: Infectious Diseases Authors: Zaki A Sherif Christian R Gomez Thomas J Connors Timothy J Henrich William Brian Reeves RECOVER Mechanistic Pathway Task Force Source Type: research

Viral diseases of the nervous system-Selected new and old viruses
Nervenarzt. 2023 Mar 21:1-8. doi: 10.1007/s00115-023-01452-0. Online ahead of print.ABSTRACTViral diseases of the nervous system are ancient and poliomyelitis was described in Egypt as early as 2000 BC. They can cause a wide range of neurological symptoms, such as meningitis, encephalitis, meningoencephalitis, Guillain-Barré-like syndrome and stroke, often leaving mild to severe residuals. Depending on the pathogen, the symptoms appear quickly within hours, or lead to increasing chronic symptoms within 1 week or months. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was newly identified in January...
Source: Herpes - March 21, 2023 Category: Infectious Diseases Authors: Uta Meyding-Lamad é Eva Maria Craemer Source Type: research

Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature
Vaccines (Basel). 2023 Feb 13;11(2):425. doi: 10.3390/vaccines11020425.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in 2019 and became a pandemic in 2020. Since then, vaccines have been approved to prevent severe illness. However, vaccines are associated with the risk of neurological complications ranging from mild to severe. Severe complications such as vaccine-induced immune thrombotic thrombocytopenia (VITT) associated with acute ischaemic stroke have been reported as rare complications post-COVID-19 vaccination. During the pandemic era, V...
Source: Herpes - February 28, 2023 Category: Infectious Diseases Authors: Wei-Ping Chen Ming-Hua Chen Shih-Ta Shang Yung-Hsi Kao Kuo-An Wu Wen-Fang Chiang Jenq-Shyong Chan Hann-Yeh Shyu Po-Jen Hsiao Source Type: research

CROI 2022: neurologic complications of HIV-1, SARS-CoV-2, and other pathogens
Top Antivir Med. 2022 Oct-Nov;30(3):475-489.ABSTRACTThe 2022 Conference on Retroviruses and Opportunistic Infections featured new and important findings about the neurologic complications of HIV-1, COVID-19, and other infections. Long-term analyses identified that cognitive decline over time, phenotypic aging, and stroke are associated with various comorbidities in people with HIV. Neuroimaging studies showed greater neuroinflammation, white matter damage, demyelination, and overall brain aging in people with chronic HIV infection. Childhood trauma and exposure to environmental pollutants contribute to these neuroimaging f...
Source: Topics in HIV Medicine - November 8, 2022 Category: Infectious Diseases Authors: Albert M Anderson Scott L Letendre Beau M Ances Source Type: research

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