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Bihemispheric Cortical Infarcts in an Adult Secondary to < b > < i > Escherichia coli < /i > < /b > K1 Meningitis
This study demonstrates the necessity of early diagnosis and treatment ofE. coli meningitis to prevent neurological complications, including stroke.Case Rep Neurol 2021;13:572 –577
Source: Case Reports in Neurology - August 24, 2021 Category: Neurology Source Type: research

Prevalence of COVID-19 Mimics in the Emergency Department
Conclusion Several potentially fatal diseases remain masked among the wave of COVID-19 mimics. It is imperative that a thorough differential diagnostic panel be considered prior to the rendering of a COVID-19 diagnosis.PMID:34334560 | DOI:10.2169/internalmedicine.6434-20
Source: Internal Medicine - August 2, 2021 Category: Internal Medicine Authors: Satoshi Kurihara Mikio Nakajima Richard H Kaszynski Yasuhiro Yamamoto Koichiro Santo Ryo Takane Hayato Tokuno Ayaka Ishihata Hitoshi Ando Maki Miwa Shoichiro Hamada Tomotsugu Nakano Masamitsu Shirokawa Hideaki Goto Yoshihiro Yamaguchi Source Type: research

Threatening blindness in a child with typical haemolytic uremic syndrome
Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children under five years of age, following a gastrointestinal infection with Shiga toxin-producing Escherichia coli (STEC) and characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (1). Central Nervous System (CNS) involvements are seen in 15% of cases, with clinical manifestations ranging from obnubilation to coma, seizures, stroke, and cortical blindness (2).
Source: Pediatric Neurology - June 24, 2021 Category: Neurology Authors: Ana ïs Corgier-Pattberg, Marie Beylerian, Stephanie Clave, Mathilde Cailliez, Benoit Testud, Beatrice Desnous Tags: Short Communication Source Type: research

A Multicentric, Randomized, Controlled Phase III Study of Centhaquine (Lyfaquin ®) as a Resuscitative Agent in Hypovolemic Shock Patients
ConclusionCenthaquine is an efficacious resuscitative agent for treating hypovolemic shock. The efficacy of centhaquine in distributive shock is being explored.Trial RegistrationClinical Trials Registry, India; ctri.icmr.org.in, CTRI/2019/01/017196; clinicaltrials.gov, NCT04045327.
Source: Drugs - June 1, 2021 Category: Drugs & Pharmacology Source Type: research

Progress and Prospect of Single-molecular ClpX ATPase Researching system-a mini-review.
Abstract ClpXP in Escherichia coli is a proteasome degrading protein substrates. It consists of one hexamer of ATPase (ClpX) and two heptamers of peptidase (ClpP). The ClpX binds ATP and translocates the substrate protein into the ClpP chamber by binding and hydrolysis of ATP. At single molecular level, ClpX harnesses cycles of power stroke (dwell and burst) to unfold the substrates, then releases the ADP and Pi. Based on the construction and function of ClpXP, especially the recent progress on how ClpX unfold protein substrates, in this mini-review, a currently proposed single ClpX molecular model system detected...
Source: Gene - January 9, 2021 Category: Genetics & Stem Cells Authors: Kang ZH, Liu YT, Gou Y, Deng QR, Hu ZY, Li GR Tags: Gene Source Type: research

Bacteriological and therapeutic features of lung abscess
Conclusion: The identification of the responsible bacteria in lung abcess remains difficult. Management is based mainly on antibiotics wich is often probabilistic, in some cases associated with physiotherapy, percutaneous scan-guided drainage or rarely surgery.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kallel, N., khemakhem, R., Abdelmouleh, K., Moussa, N., Yangui, I., Kammoun, S. Tags: Respiratory infections Source Type: research

Lipopolysaccharide-induced sepsis-like state compromises post-ischemic neurological recovery, brain tissue survival and remodeling via mechanisms involving microvascular thrombosis and brain T cell infiltration.
Abstract Sepsis predisposes for poor stroke outcome. This association suggests that sepsis disturbs post-ischemic tissue survival and brain remodeling. To elucidate this link, we herein exposed mice to 30 min intraluminal middle cerebral artery occlusion (MCAO) and induced a sepsis-like state at 72 hours post-ischemia by intraperitoneal delivery of Escherichia coli lipopolysaccharide (LPS; three doses of 0.1 or 1 mg/kg, separated by 6 hours), a major component of the bacterium's outer membrane. Neurological recovery, ischemic injury, brain remodeling and immune responses were evaluated over up to 56 days post-seps...
Source: Brain, Behavior, and Immunity - October 22, 2020 Category: Neurology Authors: Sardari M, Skuljec J, Yin D, Zec K, de Carvalho TS, Albers D, Wang C, Pul R, Popa-Wagner A, Doeppner TR, Kleinschnitz C, Dzyubenko E, Hermann DM Tags: Brain Behav Immun Source Type: research

Dynamic Arterial Elastance During Experimental Endotoxic Septic Shock: A Potential Marker of Cardiovascular Efficiency
Dynamic arterial elastance (Eadyn), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a dynamic parameter relating pressure and flow. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Eadyn in an experimental study in 18 New Zealand rabbits. Animals received placebo (SHAM, n = 6) or intravenous lipopolysaccharide (E. Coli 055:B5, 1 mg⋅kg–1) with or without (EDX-R, n = 6; EDX, n = 6) hemodynamic resuscitation (fluid bolus of 20 ml⋅kg–1 and norepinephrine for restoring mean arterial pressure). Continuous arterial pressu...
Source: Frontiers in Physiology - October 1, 2020 Category: Physiology Source Type: research

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
We present cryo-EM studies of theE. coli enzyme that show how asymmetric hexameric rings of ClpX bind symmetric heptameric rings of ClpP and interact with protein substrates. Subunits in the ClpX hexamer assume a spiral conformation and interact with two-residue segments of substrate in the axial channel, as observed for other AAA+ proteases and protein-remodeling machines. Strictly sequential models of ATP hydrolysis and a power stroke that moves two residues of the substrate per translocation step have been inferred from these structural features for other AAA+ unfoldases, but biochemical and single-molecule biophysical ...
Source: eLife - February 28, 2020 Category: Biomedical Science Tags: Structural Biology and Molecular Biophysics Source Type: research

A Simple Assay to Evaluate the Function of Human Connexin Hemichannels Expressed in Escherichia coli that Can Be Used for Drug Discovery and Mutant Analysis.
Authors: Fiori MC, Cuello LG, Altenberg GA Abstract Abnormally increased activity of connexin hemichannels contributes to cell damage in many disorders, including deafness, stroke, and cardiac infarct, and therefore hemichannels constitute a potentially important therapeutic target. Unfortunately, the available hemichannel inhibitors are not specific and most are toxic. The absence of a simple and cost-effective screening assay has made the discovery of hemichannel inhibitors difficult. Here, we present an optimized assay where human connexins are expressed in genetically modified Escherichia coli cells deficient i...
Source: Current Protocols in Pharmacology - November 24, 2019 Category: Drugs & Pharmacology Tags: Curr Protoc Pharmacol Source Type: research

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