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Bacteriological and therapeutic features of lung abscess
Conclusion: The identification of the responsible bacteria in lung abcess remains difficult. Management is based mainly on antibiotics wich is often probabilistic, in some cases associated with physiotherapy, percutaneous scan-guided drainage or rarely surgery.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kallel, N., khemakhem, R., Abdelmouleh, K., Moussa, N., Yangui, I., Kammoun, S. Tags: Respiratory infections Source Type: research

Lipopolysaccharide-induced sepsis-like state compromises post-ischemic neurological recovery, brain tissue survival and remodeling via mechanisms involving microvascular thrombosis and brain T cell infiltration.
Abstract Sepsis predisposes for poor stroke outcome. This association suggests that sepsis disturbs post-ischemic tissue survival and brain remodeling. To elucidate this link, we herein exposed mice to 30 min intraluminal middle cerebral artery occlusion (MCAO) and induced a sepsis-like state at 72 hours post-ischemia by intraperitoneal delivery of Escherichia coli lipopolysaccharide (LPS; three doses of 0.1 or 1 mg/kg, separated by 6 hours), a major component of the bacterium's outer membrane. Neurological recovery, ischemic injury, brain remodeling and immune responses were evaluated over up to 56 days post-seps...
Source: Brain, Behavior, and Immunity - October 22, 2020 Category: Neurology Authors: Sardari M, Skuljec J, Yin D, Zec K, de Carvalho TS, Albers D, Wang C, Pul R, Popa-Wagner A, Doeppner TR, Kleinschnitz C, Dzyubenko E, Hermann DM Tags: Brain Behav Immun Source Type: research

A Multicentric, Randomized, Controlled Phase III Study of Centhaquine (Lyfaquin ®) as a Resuscitative Agent in Hypovolemic Shock Patients
ConclusionCenthaquine is an efficacious resuscitative agent for treating hypovolemic shock. The efficacy of centhaquine in distributive shock is being explored.Trial RegistrationClinical Trials Registry, India; ctri.icmr.org.in, CTRI/2019/01/017196; clinicaltrials.gov, NCT04045327.
Source: Drugs - June 1, 2021 Category: Drugs & Pharmacology Source Type: research

Threatening blindness in a child with typical haemolytic uremic syndrome
Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children under five years of age, following a gastrointestinal infection with Shiga toxin-producing Escherichia coli (STEC) and characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (1). Central Nervous System (CNS) involvements are seen in 15% of cases, with clinical manifestations ranging from obnubilation to coma, seizures, stroke, and cortical blindness (2).
Source: Pediatric Neurology - June 24, 2021 Category: Neurology Authors: Ana ïs Corgier-Pattberg, Marie Beylerian, Stephanie Clave, Mathilde Cailliez, Benoit Testud, Beatrice Desnous Tags: Short Communication Source Type: research

Prevalence of COVID-19 Mimics in the Emergency Department
Conclusion Several potentially fatal diseases remain masked among the wave of COVID-19 mimics. It is imperative that a thorough differential diagnostic panel be considered prior to the rendering of a COVID-19 diagnosis.PMID:34334560 | DOI:10.2169/internalmedicine.6434-20
Source: Internal Medicine - August 2, 2021 Category: Internal Medicine Authors: Satoshi Kurihara Mikio Nakajima Richard H Kaszynski Yasuhiro Yamamoto Koichiro Santo Ryo Takane Hayato Tokuno Ayaka Ishihata Hitoshi Ando Maki Miwa Shoichiro Hamada Tomotsugu Nakano Masamitsu Shirokawa Hideaki Goto Yoshihiro Yamaguchi Source Type: research

Bihemispheric Cortical Infarcts in an Adult Secondary to < b > < i > Escherichia coli < /i > < /b > K1 Meningitis
This study demonstrates the necessity of early diagnosis and treatment ofE. coli meningitis to prevent neurological complications, including stroke.Case Rep Neurol 2021;13:572 –577
Source: Case Reports in Neurology - August 24, 2021 Category: Neurology Source Type: research

Neuroinductive properties of mGDNF depend on the producer, < i > E < /i > . < i > Coli < /i > or human cells
by Dzhirgala V. Shamadykova, Dmitry Y. Panteleev, Nadezhda N. Kust, Ekaterina A. Savchenko, Ekaterina Y. Rybalkina, Alexander V. Revishchin, Galina V. Pavlova The glial cell line‐derived neurotrophic factor (GDNF) is involved in the survival of dopaminergic neurons. Besides, GDNF can also induce axonal growth and creation of new functional synapses. GDNF potential is promising for translation to treat diseases associated with neuronal death: neurodege nerative disorders, ischemic stroke, and cerebral or spinal cord damages. Unproductive clinical trials of GDNF for Parkinson’s disease treatment have induced to study th...
Source: PLoS One - October 11, 2021 Category: Biomedical Science Authors: Dzhirgala V. Shamadykova Source Type: research

UCHL1 protects against ischemic heart injury via activating HIF-1 α signal pathway
Redox Biol. 2022 Mar 18;52:102295. doi: 10.1016/j.redox.2022.102295. Online ahead of print.ABSTRACTUbiquitin carboxyl-terminal esterase L1 (UCHL1) has been thought to be a neuron specific protein and shown to play critical roles in Parkinson's Disease and stroke via de-ubiquiting and stabilizing key pathological proteins, such as α-synuclein. In the present study, we found that UCHL1 was significantly increased in both mouse and human cardiomyocytes following myocardial infarction (MI). When LDN-57444, a pharmacological inhibitor of UCHL1, was used to treat mice subjected to MI surgery, we found that administration of LDN...
Source: Cancer Control - March 27, 2022 Category: Cancer & Oncology Authors: Bingchuan Geng Xiaoliang Wang Ki Ho Park Kyung Eun Lee Jongsoo Kim Peng Chen Xinyu Zhou Tao Tan Chunlin Yang Xunchang Zou Paul M Janssen Lei Cao Lei Ye Xuejun Wang Chuanxi Cai Hua Zhu Source Type: research

Therapeutic Use and Chronic Abuse of CNS Stimulants and Anabolic Drugs
Curr Issues Mol Biol. 2022 Oct 15;44(10):4902-4920. doi: 10.3390/cimb44100333.ABSTRACTThe available evidence suggests that affective disorders, such as depression and anxiety, increase risk for accelerated cognitive decline and late-life dementia in aging individuals. Behavioral neuropsychology studies also showed that cognitive decline is a central feature of aging impacting the quality of life. Motor deficits are common after traumatic brain injuries and stroke, affect subjective well-being, and are linked with reduced quality of life. Currently, restorative therapies that target the brain directly to restore cognitive a...
Source: Current Issues in Molecular Biology - October 26, 2022 Category: Molecular Biology Authors: Daniela Coli ță Cezar-Ivan Coli ță Dirk M Hermann Eugen Coli ță Thorsten R Doeppner Ion Udristoiu Aurel Popa-Wagner Source Type: research

Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins (Basel). 2022 Oct 11;14(10):696. doi: 10.3390/toxins14100696.ABSTRACTThe importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders such as stroke, epilepsy, and cancer. The immune response within the brain involves the presence of CNS resident cells; mainly glial cells, such as microglia, the CNS resident macrophages. We evaluated the peptide Ca-MAP1 bioinspired on the C. albicans immature cytolytic toxin candidalysin to develop ...
Source: Cancer Control - October 26, 2022 Category: Cancer & Oncology Authors: Pedro Henrique de Oliveira Cardoso Ana Paula de Ara újo Boleti Patr ícia Souza E Silva Lincoln Takashi Hota Mukoyama Alexya Sandim Guindo Luiz Filipe Ramalho Nunes de Moraes Caio Fernando Ramalho de Oliveira Maria Ligia Rodrigues Macedo Cristiano Marcel Source Type: research

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