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Major acute cardiovascular events after dengue infection –A population-based observational study
ConclusionsThe risks for MACEs are significantly higher in the immediate time period after dengue infection. Since dengue infection is potentially preventable by early recognition and vaccination, the dengue-associated MACE should be taken into consideration when making public health management policies.
Source: PLoS Neglected Tropical Diseases - February 7, 2022 Category: Tropical Medicine Authors: Kai-Che Wei Source Type: research

Neurological manifestations of dengue fever
Conclusions: In this study of patients admitted with dengue, neurological complications due to dengue were seen in 2.64%. Encephalopathy, encephalitis and syncope were the commonest manifestations, followed by acute symptomatic seizures, intracranial haemorrhage and GBS. The entire neuroaxis can be involved in dengue infection. To the best of our knowledge, this is the largest reported study of neurological complications of dengue.
Source: Annals of Indian Academy of Neurology - December 4, 2021 Category: Neurology Authors: Rahul Kulkarni Shripad Pujari Dulari Gupta Source Type: research

Case Report: Dengue Hemorrhagic Fever with Ischemic Stroke
We report a case of ischemic stroke in a patient with dengue hemorrhagic fever. A 52-year-old previously healthy male presented with a history of fever for 2 days, and left-sided weakness and numbness of sudden onset. MRI scanning showed a right-sided thalamic lacunar infarct. Diagnosis of dengue fever was made based on leuco-thrombocytopenia, positive dengue nonstructural protein-1 (NS-1) antigen, and positive dengue IgM antibodies. Severity of limb weakness correlated with the critical phase of dengue hemorrhagic fever (DHF). He was discharged home with good recovery from neurological symptoms and disability. Strokes are...
Source: The American Journal of Tropical Medicine and Hygiene - November 15, 2021 Category: Tropical Medicine Authors: B W M K E Basnayake K G S K Somaratne C U Goonetilleke P M Y I Tilakaratna U K Ranawaka Source Type: research

Safety of Temporary Interruption of Antiplatelet Therapy in Dengue Fever with Thrombocytopenia
Dengue fever, caused by a flavivirus transmitted by Aedes mosquitoes, is endemic in more than 100 countries with 2.5 billion people at risk.1 With climate change and globalization causing geographical expansion of Aedes mosquitoes, increased exposure especially in dengue-na ïve populations is predicted.2,3 Thrombocytopenia commonly occurs with dengue 4 and may be associated with bleeding. Avoidance of intramuscular injections, bed rest and measures to reduce risk of falls are usually advised. Increasingly, dengue occurs in older adults,5–7 and adult patients with de ngue fever may have comorbidities such as ischemic hea...
Source: Journal of Infection - November 30, 2020 Category: Infectious Diseases Authors: Po Ying Chia, Htet Lin Htun, Yee Sin Leo, David Chien Lye Source Type: research

Pattern Recognition Approach to Brain MRI Findings in Patients with Dengue Fever with Neurological Complications
Conclusion: Radiologists should be aware of various MRI brain findings in dengue and a pattern recognition approach often helps in reaching the correct diagnosis albeit after exclusion of other differentials based on laboratory studies.
Source: Neurology India - October 27, 2020 Category: Neurology Authors: Sameer Vyas Nirmalya Ray Muniraju Maralakunte Ajay Kumar Paramjeet Singh Manish Modi Manoj Kumar Goyal Naveen Sankhyan Ashish Bhalla Navneet Sharma Muralidharan Jayashree Source Type: research

Fatal Cerebral Haemorrhage in a Thrombolysed Patient with Ischaemic Stroke Who Developed Interval Thrombocytopaenia from Acute Dengue Infection.
PMID: 32246712 [PubMed - as supplied by publisher]
Source: Annals of the Academy of Medicine, Singapore - January 31, 2020 Category: General Medicine Authors: Pang YH, Divakar TG, De Silva DA Tags: Ann Acad Med Singapore Source Type: research

Neurological complications associated with dengue virus infection.
CONCLUSIONS: The spectrum of neurological complications from dengue virus is broad. There are no reliable data on its real incidence because most of the studies published to date are isolated series or cases. PMID: 31310001 [PubMed - in process]
Source: Revista de Neurologia - July 18, 2019 Category: Neurology Authors: Carod-Artal FJ Tags: Rev Neurol Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Diabetic patients suffering dengue are at risk for development of dengue shock syndrome/severe dengue: emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity
ConclusionsThese data could help narrow down the number of targets in the triage for risky DM2 dengue patients to those with suboptimal glycemic control and co-existing comorbidity(ies).
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Cerebral vasculitis and lateral rectus palsy – two rare central nervous system complications of dengue fever: two case reports and review of the literature
ConclusionsCentral nervous system vasculitis due to dengue infection is a very rare phenomenon, and to the best of our knowledge, only one case of central nervous system vasculitis has been reported to date, in a patient of pediatric age. Cranial nerve palsy related to dengue infection is also rare, and only a few cases of isolated abducens nerve palsy have been reported to date. The two cases described in this report illustrate the rare but important central nervous system manifestations of dengue fever and support the fact that the central nervous system is one of the important systems that can be affected in patients with dengue infection.
Source: Journal of Medical Case Reports - April 19, 2018 Category: General Medicine Source Type: research

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