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Total 1451 results found since Jan 2013.
COVID-19-Associated Cerebrovascular Events: A Case Series Study and a Literature Review of Possible Mechanisms
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects multiple body systems, including the nervous system. Cerebrovascular accidents can also occur. Patients with comorbid illnesses have severe manifestations and poor outcomes. Despite the proper mechanism of SARS-CoV-2 infection-associated stroke having not yet been settled, various possible mechanisms have been hypothesized. One possibility is that the virus causes endothelial dysfunction and immune-mediated injury. Another possibility is that the trans-neuronal spread of the virus affects brain tissue. In addition, hypercoagulability caused by SARS-CoV-2 ...
Source: Case Reports in Neurology - February 3, 2023 Category: Neurology Source Type: research
The U.S. Still Doesn ’ t Have Good COVID-19 Data. Here ’ s Why That ’ s a Problem
Check the COVID-19 Data Tracker from the U.S. Centers for Disease Control and Prevention (CDC), and you’ll get a rundown of the latest case numbers, hospitalizations, and deaths. Those categories might seem straightforward, but the data, say many experts, are telling us a lot less than we think they are.
That’s because it’s getting increasingly difficult to parse who is hospitalized or dies from COVID-19, and who is hospitalized or dies from another reason but with COVID-19. Across the U.S., “COVID-19 hospitalizations” represent all kinds of patients: those who need hospital-level care for sev...
Source: TIME: Health - January 30, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
FDA Experts Vote to Make All COVID-19 Vaccines and Boosters Bivalent
In a unanimous decision, all 21 voting members of the U.S. Food and Drug Administration’s (FDA) vaccine committee recommended that the U.S. start using the same COVID-19 virus strain in all of the COVID-19 vaccines, including primary and booster doses.
That means the bivalent booster dose, which targets both the original SARS-CoV-2 strain and the Omicron BA.4/5 strains, would soon become the only type used for all primary shots and boosters.
The decision reflects a turning point in the pandemic. Until now, vaccine makers have tried to keep up with constantly evolving variants, but they’ve always been a few step...
Source: TIME: Health - January 27, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
Cardiovascular Complications in Coronavirus Disease 2019-Pathogenesis and Management
Semin Respir Crit Care Med. 2023 Feb;44(1):21-34. doi: 10.1055/s-0042-1760096. Epub 2023 Jan 16.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has caused a devastating impact on morbidity and mortality around the world. Severe acute respiratory syndrome-coronavirus-2 has a characteristic tropism for the cardiovascular system by entering the host cells and binding to angiotensin-converting enzyme 2 receptors, which are expressed in different cells, particularly endothelial cells. This endothelial injury is linked by a direct intracellular viral invasion leading to inflammation, microthrombosis, and angiogenesis. C...
Source: Respiratory Care - January 16, 2023 Category: Respiratory Medicine Authors: Marcos I Restrepo Judith Marin-Corral Juan J Rodriguez Valeria Restrepo Rodrigo Cavallazzi Source Type: research
Cardiovascular Complications in Coronavirus Disease 2019 —Pathogenesis and Management
Semin Respir Crit Care Med 2023; 44: 021-034 DOI: 10.1055/s-0042-1760096The coronavirus disease 2019 (COVID-19) pandemic has caused a devastating impact on morbidity and mortality around the world. Severe acute respiratory syndrome-coronavirus-2 has a characteristic tropism for the cardiovascular system by entering the host cells and binding to angiotensin-converting enzyme 2 receptors, which are expressed in different cells, particularly endothelial cells. This endothelial injury is linked by a direct intracellular viral invasion leading to inflammation, microthrombosis, and angiogenesis. COVID-19 has been associated with...
Source: Seminars in Respiratory and Critical Care Medicine - January 16, 2023 Category: Respiratory Medicine Authors: Restrepo, Marcos I. Marin-Corral, Judith Rodriguez, Juan J. Restrepo, Valeria Cavallazzi, Rodrigo Tags: Review Article Source Type: research
Original Article: Increased Stroke Severity and Mortality in Patients with SARS-CoV-2 Infection: An Analysis from the N3C Database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research
Increased stroke severity and mortality in patients with SARS-CoV-2 infection: An analysis from the N3C database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research
A case of ischemic stroke and transient thrombocytopenia in a young female following adenoviral vector-based COVID-19 vaccination: Was the association incidental or causal?
We report a 23-year-old healthy female who developed seizures, altered sensorium, and left hemiparesis, 20 days after receiving the first dose of adenoviral vector-based COVID-19 vaccine "Covishield™." The patient had transient thrombocytopenia. The D-dimer level was 2460 ng/mL. Magnetic resonance imaging (MRI) demonstrated occlusion of M2 segment of the middle cerebral artery and cerebral infarction. Platelet factor-4 antibodies level was normal. Treatment with aspirin and antiepileptic drugs resulted in a remarkable recovery. This is the first Indian case report of ischemic stroke and transient thrombocytopenia followi...
Source: Primary Care - January 9, 2023 Category: Primary Care Authors: Shweta Pandey Ravindra Kumar Garg Pooja Tripathi Hardeep S Malhotra Neeraj Kumar Source Type: research
SARS-CoV-2 infection and SLE: endothelial dysfunction, atherosclerosis, and thrombosis
We present systemic lupus erythematosus (SLE) as a model rheumatic disease with endothelial dysfunction and discuss its mechanisms, factors that influence the early onset and rapid progression of atherosclerosis, and the increased risk of thromboembolic events. We focus on established methods to improve endothelium function, including statins, antiplatelet, and antithrombotic therapy. Hypercoagulable and hypofibrinolitic states and a hyperinflammatory response characterize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathogenic mechanisms are typical for an acute phase of Covid-19 post-Co...
Source: Atherosclerosis - January 9, 2023 Category: Cardiology Authors: Wojciech P łazak Leszek Drabik Source Type: research
Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromes
CONCLUSIONS: We showed an elevation of CSF biomarkers of neuroinflammation in NeuroCOVID patients and a rise of CSF NfL, evocative of neuronal damage. However, longitudinal studies are needed to determine whether NeuroCOVID could evolve into a chronic neurodegenerative condition.PMID:36610823 | PMC:PMC9708608 | DOI:10.1016/j.neurol.2022.11.002
Source: Revue Neurologique - January 7, 2023 Category: Neurology Authors: H Chaumont F Kaczorowski A San-Galli P P Michel B Tressi ères E Roze I Quadrio A Lannuzel Source Type: research
Association of body mass index with COVID-19-related neurologic sequelae: a retrospective cohort study
This study demonstrates the absence of an association between BMI and neurologic manifestations following acute COVID-19 illness. Prospective studies using standardized data collection tools and direct measures of body fat are warranted to obtain more valid effect estimates.
Source: Clinical and Experimental Medicine - December 16, 2022 Category: Research Source Type: research
Telemedicine During COVID-19 Pandemic: Lesson Learned from the Lazio Region Infectious Diseases and Emergency Department Network
We describe the teleconsultation (TC) model in the Lazio Region. It uses a hub-and-spoke network system on geographic regional basis using a web based digital platform, termed ADVICE with the aim to connect regional Emergency Departments (EDs) and Infectious Diseases (ID) acute and critical care settings for patients with acute ID syndrome. Between January 2020 and June 2021, the ADVICE platform received 18.686 TCs: of them, 10838 requests (58%) were for ID TCs in 7996 patients, followed by 2555(13%) requests for trauma, 2286(12%) for acute complex syndrome and 1681 (8%) for Stroke TCs. Three quarter of ID TCs were request...
Source: Journal of Medical Systems - December 7, 2022 Category: Information Technology Source Type: research
