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Source: JAHA:Journal of the American Heart Association
Condition: Stroke

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Total 368 results found since Jan 2013.

Circulating microRNAs Serve as Novel Biological Markers for Intracranial Aneurysms Stroke
Conclusions Our data suggest that circulating miRNAs may be novel biological markers that are useful in assessing the likelihood of IA occurrence.
Source: JAHA:Journal of the American Heart Association - September 23, 2014 Category: Cardiology Authors: Li, P., Zhang, Q., Wu, X., Yang, X., Zhang, Y., Li, Y., Jiang, F. Tags: Stroke Source Type: research

Declining Rates of Fatal and Nonfatal Intracerebral Hemorrhage: Epidemiological Trends in Australia Stroke
Conclusions Overall and fatal ICH rates have fallen in this large Australian population. Improvements in cardiovascular prevention and acute care may explain declining rates. There was no evidence of an increase in devastated survivors because the longer term mortality of 30-day survivors has not increased over time.
Source: JAHA:Journal of the American Heart Association - December 8, 2014 Category: Cardiology Authors: Gattellari, M., Goumas, C., Worthington, J. Tags: Stroke Source Type: research

Management of Vascular Risk Factors in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) Stroke
Conclusions Site-based risk-factor control improved significantly in the first 6 months and over the long term in CREST but was often suboptimal. Intensive medical management should be considered for future trials of carotid revascularization. Clinical Trial Registration URL: ClinicalTrials.gov. Unique identifier: NCT00004732.
Source: JAHA:Journal of the American Heart Association - November 26, 2014 Category: Cardiology Authors: Meschia, J. F., Voeks, J. H., Leimgruber, P. P., Mantese, V. A., Timaran, C. H., Chiu, D., Demaerschalk, B. M., Howard, V. J., Hughes, S. E., Longbottom, M., Howard, A. G., Brott, T. G. Tags: Stroke Source Type: research

Traumatic Brain Injury Disrupts Cerebrovascular Tone Through Endothelial Inducible Nitric Oxide Synthase Expression and Nitric Oxide Gain of Function Stroke
Conclusions The mechanism of profound cerebral artery vasodilation after TBI is a gain of function in vascular NO production by 60-fold over controls, resulting from upregulation of the inducible isoform of NO synthase in the endothelium.
Source: JAHA:Journal of the American Heart Association - December 19, 2014 Category: Cardiology Authors: Villalba, N., Sonkusare, S. K., Longden, T. A., Tran, T. L., Sackheim, A. M., Nelson, M. T., Wellman, G. C., Freeman, K. Tags: Stroke Source Type: research

New York State: Comparison of Treatment Outcomes for Unruptured Cerebral Aneurysms Using an Instrumental Variable Analysis Stroke
Conclusions Using a comprehensive all-payer cohort of patients in New York State with unruptured cerebral aneurysms, we did not identify an association of treatment method with mortality or 30-day readmission. Clipping was associated with a higher rate of discharge to rehabilitation and longer length of stay.
Source: JAHA:Journal of the American Heart Association - July 13, 2015 Category: Cardiology Authors: Bekelis, K., Missios, S., Coy, S., Singer, R. J., MacKenzie, T. A. Tags: Stroke Source Type: research

Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia Stroke
Conclusions The protective effects of H2S are mediated by thiosulfate that is transported across cell membrane by NaS-2 and exerts antiapoptotic effects via persulfidation of caspase-3. Given the established safety track record, thiosulfate may be therapeutic against ischemic brain injury.
Source: JAHA:Journal of the American Heart Association - November 6, 2015 Category: Cardiology Authors: Marutani, E., Yamada, M., Ida, T., Tokuda, K., Ikeda, K., Kai, S., Shirozu, K., Hayashida, K., Kosugi, S., Hanaoka, K., Kaneki, M., Akaike, T., Ichinose, F. Tags: Stroke Source Type: research

N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) Levels are Increased in Patients With Transient Ischemic Attack Accompanied by Nonfocal Symptoms Stroke
Conclusion NT-proBNP levels are increased in patients with TIA accompanied by nonfocal symptoms.
Source: JAHA:Journal of the American Heart Association - December 15, 2015 Category: Cardiology Authors: Plas, G. J. J., Jurg, S. D., Brusse-Keizer, M., Dippel, D. W. J., Koudstaal, P. J., den Hertog, H. M. Tags: Stroke Source Type: research

Cardiac Time Intervals Measured by Tissue Doppler Imaging M-mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases Imaging
Conclusion The cardiac time intervals identify impaired cardiac function in individuals with hypertension, not only independent of conventional risk factors but also in participants with a normal conventional echocardiographic examination. The IVRT/ET and MPI are independent predictors of future cardiovascular disease especially in participants with known hypertension.
Source: JAHA:Journal of the American Heart Association - January 19, 2016 Category: Cardiology Authors: Biering-Sorensen, T., Mogelvang, R., Schnohr, P., Jensen, J. S. Tags: Risk Factors, Hypertension, Echocardiography, Quality and Outcomes, Ischemic Stroke Imaging Source Type: research

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans Stroke
Conclusions The GCAS model successfully generated gradual and continuous CBF reduction over 28 days, with replication of key histological, radiological, and behavioral features associated with cerebral hypoperfusion leading to VCI.
Source: JAHA:Journal of the American Heart Association - February 22, 2016 Category: Cardiology Authors: Hattori, Y., Enmi, J.-i., Iguchi, S., Saito, S., Yamamoto, Y., Tsuji, M., Nagatsuka, K., Kalaria, R. N., Iida, H., Ihara, M. Tags: Animal Models of Human Disease, Cerebrovascular Disease/Stroke, Cognitive Impairment, Atherosclerosis, Stenosis Source Type: research

ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease Stroke
Conclusions In people with MCI and AD, the capacity of CSF to facilitate ABCA1-mediated cholesterol efflux is impaired. This lesser cholesterol efflux in MCI supports a pathophysiological role for ABCA1-mediated cholesterol transport in early neurodegeneration.
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Yassine, H. N., Feng, Q., Chiang, J., Petrosspour, L. M., Fonteh, A. N., Chui, H. C., Harrington, M. G. Tags: Lipids and Cholesterol Stroke Source Type: research

Pacemakers as Atrial Fibrillation Detectors: Finding Racial Differences and Opportunities for Preventing Stroke Editorial
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Meschia, J. F. Tags: Atrial Fibrillation, Epidemiology, Race and Ethnicity, Genetics, Ischemic Stroke Editorial Source Type: research

Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) Stroke
Conclusions Small+medium HDL-P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL-P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Kim, D. S., Li, Y. K., Bell, G. A., Burt, A. A., Vaisar, T., Hutchins, P. M., Furlong, C. E., Otvos, J. D., Polak, J. F., Arnan, M. K., Kaufman, J. D., McClelland, R. L., Longstreth, W. T., Jarvik, G. P. Tags: Lipids and Cholesterol, Oxidant Stress, Cardiovascular Disease, Cerebrovascular Disease/Stroke Source Type: research

Rising Stroke Incidence in Young Adults: More Epidemiological Evidence, More Questions to Be Answered Editorial
Source: JAHA:Journal of the American Heart Association - May 10, 2016 Category: Cardiology Authors: Bejot, Y., Delpont, B., Giroud, M. Tags: Epidemiology, Cerebrovascular Disease/Stroke Editorial Source Type: research

Electronic Alert System for Improving Stroke Prevention Among Hospitalized Oral-Anticoagulation-Naïve Patients With Atrial Fibrillation: A Randomized Trial Preventive Cardiology
Conclusions Versus standard care, the alert system modestly improved OAC prescription among consecutive hospitalized AF patients. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT02455102.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Silbernagel, G., Spirk, D., Hager, A., Baumgartner, I., Kucher, N. Tags: Atrial Fibrillation, Anticoagulants, Quality and Outcomes Preventive Cardiology Source Type: research

Left Atrial Appendage Closure Under Intracardiac Echocardiographic Guidance: Feasibility and Comparison With Transesophageal Echocardiography Interventional Cardiology
ConclusionsTranscatheter left atrial appendage closure with intracardiac echocardiography guidance is safe and feasible.
Source: JAHA:Journal of the American Heart Association - September 27, 2016 Category: Cardiology Authors: Matsuo, Y., Neuzil, P., Petru, J., Chovanec, M., Janotka, M., Choudry, S., Skoda, J., Sediva, L., Kurabayashi, M., Reddy, V. Y. Tags: Atrial Fibrillation, Imaging, Ischemic Stroke, Thrombosis Original Research Source Type: research