Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans [Stroke]

Conclusions
The GCAS model successfully generated gradual and continuous CBF reduction over 28 days, with replication of key histological, radiological, and behavioral features associated with cerebral hypoperfusion leading to VCI.

Source: JAHA:Journal of the American Heart Association - February 22, 2016 Category: Cardiology Authors: Hattori, Y., Enmi, J.-i., Iguchi, S., Saito, S., Yamamoto, Y., Tsuji, M., Nagatsuka, K., Kalaria, R. N., Iida, H., Ihara, M. Tags: Animal Models of Human Disease, Cerebrovascular Disease/Stroke, Cognitive Impairment, Atherosclerosis, Stenosis Source Type: research