ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease [Stroke]

Conclusions In people with MCI and AD, the capacity of CSF to facilitate ABCA1-mediated cholesterol efflux is impaired. This lesser cholesterol efflux in MCI supports a pathophysiological role for ABCA1-mediated cholesterol transport in early neurodegeneration.

http://jaha.ahajournals.org/cgi/content/short/5/2/e002886?rss=1

Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Yassine, H. N., Feng, Q., Chiang, J., Petrosspour, L. M., Fonteh, A. N., Chui, H. C., Harrington, M. G. Tags: Lipids and Cholesterol Stroke Source Type: research